Extra (CMT, Tetanus, Herpes Zoster and MadCow)

Question 1

What is Charcot Mary Tooth

Answer 1

Inherited PNS Polyneuropathy w/ Aut Dom mutation of pup22 on Chromosome 17

Question 2

What are the Presentations of CMT

Answer 2

Foot drop (peroneal palsy)
Stork Thin legs
Hammer curled toes
PES Planus (Flat foot) and PES Cavus(Arched foot)

Question 3

How is CMT Diagnosed

Answer 3

Nerve biopsy
Genetic test (Pup22 mutation)

Question 4

How is CMT Managed

Answer 4

Supportive w/ orthotic and physio

Question 5

What is Tetanus

Answer 5

Innoculation of Clostridium Tetani by standing on dirty soil

Question 6

What is the pathology of tetanus

Answer 6

Tetanospasmin toxin produced and travels up axons = Involuntary muscle spasm (Tetany)

Question 7

How is Tetanus managed

Answer 7

Vaccination

Question 8

What two pathologies does herpes Zoster cause bi modally

Answer 8

chicken pox <16
Shingles

Shingles

Question 9

What are the symptoms of Herpes Zoster

Answer 9

Painful rash in single dermatome

Tx = Aciclovir (Antiviral)

Question 10

Mad cow disease is also known as what

Answer 10

Prion

Question 11

What is Prion

Answer 11

Idiopathic misfolded proteins deposit in Cerebrum and cerebellum = cerebellar dysfunction
NO TREATMENT

Question 12

How is herpes zoster treated

Answer 12

Oral Aciclovir

Question 13

What causes shingles

Answer 13

Peripheral nerves attacked by dorsal root