Guillian Barre syndrome Flashcards
What is GBS
Inflammatory Demyelinating polyneuropathy post gastroenteritis and URTI
What can cause GBS
Idiopathic Post infection (Camplyobacter, Mycoplasma and EBV) -Gastroenteritis -Upper Resp tract infection
What are the features of GBS
Ascending lower limb weakness(symmetrical) Paraesthesia/ Paralysis LMN signs in lower limbs -Hypotonia -Paralysis -Areflexia CN Signs -Facial nerve palsy (CN6) -Bulbar palsy (CN7) -Diplopia (CN3) Resp weakness
What are the Bedside investigations for GBS
Spirometry (reduced FVC)
Bloods and ABG (Check T2 Resp fail)
Anti-ganglioside antibodies
What other investigations can you do for GBS
Lumbar Puncture
- raised protein
- albuminocytological dissociation (normal glucose and cell count)
What is albuminocytological dissociation of GBS
NORMAL GLUCOSE AND CELL COUNT
NORMAL GLUCOSE
How would you manage bedside GBS
Spirometry with ABG and Ventilation
Reduce VTW w/LMWH
Protect pressure areas
How would you medically manage GBS
IV Immunoglobulin With Plasma exchange
Plasmapheresis
What is Miller Fisher syndrome
GBS variant which presents with Ataxia, Opthalmoplegia and areflexia
Positive for Anti GQ1b antibodies
What are the LMN signs of GBS
Hypotonia
Paralysis
Areflexia
What are the Cranial Nerve signs of GBS
Facial nerve palsy
Bulbar palsy
Diplopia
What antibodies are found in GBS
Anti ganglioside
What is the overall term for the pathology in GBS
Molecular mimicry GBS
What is the molecular memory found in GBS
Schwann cell like organism antigens = AB produced
AB Vs Schwann cell = Demyelination and Polyneuropathy
When is IV Ig treatment contraindicated in GBS
If IgA Deficient
