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Flashcards in FHDT Neoplasia Dr. Nyanda Deck (15)
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1

When is drug therapy used?

drug therapy is used when the tumor has spread, or may spread, to all areas of the body.

2

What does the type of treatment depend on?

The type of treatment depends on the stage of the cancer

3

what is the treatment for non-small cell lung cancer?

radiation therapy

4

what is the treatment for small cell lung cancer?

perform surgery

5

it is the use of high nrg x-rays or other particles to destroy cancer cells
it's good for treating non-small cell cancer cells

radiation therapy

6

what are side effects of radiation therapy?

fatigue, malaise (feeling unwell), loss of apetite, and skin irritation at treatment site

7

it's use of drugs to kill cancer cells.
a combo of drugs is often used
drugs can be cell cycle phase specific or cell cycle phase nonspecific.

chemotherapy

8

they're agents with mjr activity in a particular phase of the cell cycle
they're schedule dependent

cell cycle phase specific chemotherapeutics

9

they're agents with significant activity in multiple phases of the cell cycle
they're dose dependent

cell cycle phase nonspecific chemotherapeutics

10

it's the largest group of chemotherapeutics
it includes:
alkylating agents
antimetabolites
antitumor antibiotics
plant alkaloids
misc.

cytotoxic drugs

11

they're cell cycle phase nonspecific compounds that transfer an alkyl group to the 7 nitrogen atom of guanine residues in one or both strands of DNA
they're main effect is on DNA synthesis (S phase) with most cytotoxicity to rapidly proliferating cells (hair cells, GI tract cells, taste buds, and tumor cells)
all are electrophilic molecules that covalently modify nucleophilic molecules in cells
DNA is most important adduct (N7 and O6 of guanine) residues in one or both strands of DNA

alkylating agents pt. 1: general info

12

they're used to treat:
hodgkin's disease
non-hodgkin's lymphoma
ovarian carcinoma
and are used for immunosuppression in transplantation

alkylating agents pt. 2: clinical uses of alkylating agents

13

toxicity results in bone marrow (BM) depression
toxicity is dose limiting

alkylating agents pt. 3: toxicity

14

side effects are:

nausea/vomiting
alopecia
diarrhea
sterility

alkylating agents pt. 4: side effects of alkylating agents

15

they're a type of alkylating agent
they form a platinum coordination complex , which forms cross-links with DNA and inhibits DNA synthesis (S phase)
they're used to treat testicular, bladder, lung, and ovarian carcinoma
adverse effects include nephrotoxicity
members include: cisplatin, carboplatin, and oxaliplatin

platinum analogs