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Flashcards in FHDT pharmacology Deck (23)
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1

What a drug does to my body

It includes

  • drug action
  • receptor theory
  • qualntitative aspects of drug addiction
  • dose-response curves

Pharmacodynamics

2

What my body does to a drug

It includes:

  • Absorption
  • Distribution
  • Metabolism
  • Elimination
  • Bioavalibility and bioequivalence
  • Fluid compartments
  • Phase reactions

Pharmacokinetics

3

 

  1. What kind of drug is it? What class of drug is it? What group of drug is it
  2. Mechanism of action of the drug (site of action of drug)
  3. Clinical applications (uses). I need to know this is the disease
  4. No drug is w/o any side effects, I need to know adverse effects of drug
  5. Drug-drug interactions. If pt. gets 2 dugs, the body may have something that might alter the drug. I need to know the counterindications.

Golden rule of pharmacology:

4

It's the study of what drugs do and how they do it

pharmacology

5

It's defined as any synthetic or natural chemical substance used in the treatment, prevention, and diagnosis of disease

drug

6

  1. class/group of drug
  2. mechanism of action of drug
  3. therapeutic applications of drug
  4. adverse and toxic effects of drug
  5. drug-drug interactions

Study guide for pharmacology (know these 5 things for every drug we're required to know)

7

It's how the drug works, usually by enhancing or inhibiting cell function (mechanism)

action

8

it's consequence of drug action on the body (benefit/result)

effect

9

It's action that occurs at therapeutic dose levels 

side effects

10

it's action that occurs when blood concentration is above therapeutic level

toxic effect

11

drug that produces en effect comparable to endogenous ligand

agonist

12

drug that blocks or inhibits action of an endogenous compound or another drug

antagonist

13

Measure of amount of drug required for effect (ED50)

potency

14

Maximum effect obtained with drug 

efficacy

15

Effect of incremental increase in dose

Slope:

16

Reproducibility of data. conditions in body that affect the drugs action

Variability

17

Drug that binds to a receptor and produces an effect. An ____may displace an endogenous ligand from the receptor.

agonist

18

Drug that binds to a receptor and produces no effect.

antagonist

19

Drug that binds to a receptor and produces an intermediate effect

Partial Agonist (Also called a mixed agonist or agonist/antagonist.)

20

Drug that binds to a receptor and produces an effect opposite that of an agonist. (Useful in treating diseases caused by receptor over expression; Also, called a negative antagonist

inverse agonist (aka negative antagonist)

21

Maximal effect can be achieved
Dose-response curve shifted to right

Competitive Antagonism

22

Increasing dose of agonist does not reverse inhibition
Receptor removed from available pool

Non-Competitive Antagonism

23

Intrinsic agonist action
Presence diminished effect of primary agonist
When both present at maximum doses, maximal effect diminished

Partial Agonist (mixed; agonist/antagonist)