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Flashcards in Final 20 Deck (35):
1

Type 1 rapid hypersensitivity

Atopic allergy.
Most common
IeG antibody class
Anaphylaxis
Allergic asthma
Allergies to specific antigens

2

Type 2: cytotoxic

Reaction of IgAntibody made by immune system
Directed against one or more of individuals own proteins

3

Allergic rhinitis

Hay fever
Airborne allergens
Plant
Mild
Dust
Animal
Wool
Food
Pollution

4

First exposure to allergen

IeG binds to surface of basophils and mast cells
These cells have vasoactive amines (histamines)
Once this happens, person is sensitized to that allergen

5

Elevated lymphocytes

Viral

6

Elevated neutrophils

Bacterial

7

Eosinophils

1-2%

8

Patch test

Reserved for contact dermatitis

9

Food diary

If skin testing is not conclusive, then do a food diary

10

IgE

<100

11

Decongestants

Cause vasoconstriction of inflamed tissue, reducing EDEMA
No glaucoma
No urinary retention
No hypertension

12

Decongestant example

Sudafed

13

Antihistamine

Block histamine from binding to receptor
Prevents vasodilation and capillary leak

14

Antihistamine examples

Benadryl
Claritin
Zyrtec
Allegra

15

Corticosteroids

Decrease inflammation
Prevent synthesis of mediators

16

Mast cell stabilizing drugs

Prevent mast cell from opening when an alllergen binds to IgE

Nasalcrom

17

Leukotriene anatagonist

Manage and prevent rhinitis

Singular

18

Desensitization therapy

Allergy shots
Cannot be avoided

19

Penicillin allergy

Cephalosporin allergy?

20

Banana or avocado allergy

Latex allergy?

21

Examples of type 2

Immune hemolytic Anemia
Immune thrombocytopenia outputs
Hemolytic transfusion reaction
Goodpastures syndrome
Drug induced hemolytic anemia

22

Plasmapheresis

Filtration of the plasma to remove specific substances

23

Type 3 immune complex reactions

Formation of large and small immune complexes
Lupus
RA

24

Circulating complexes usually lodge in

Kidneys
Skin
Joints
Small blood vessels

25

RA

Type 3
Immunicomplexes lodge in joint spaces
Scarring
Fibrous changes
Tissue destruction

26

Lupus

Immune complexes lodge in vessels causing vasculitis
Glomeruli
Arthritis

27

Type 4

Sensitized T cell from previous exposure
Release chemical mediators and macrophages
Hours to days

28

Type 4 example

TB test
Poison ivy
Contact dermatitis
Tissue transplant rejections
Sarcoidosis

29

Lupus clinical manifestations

Butterfly rash
Polyarthritis
Osteonectrosis
Muscle atrophy
Fever fatigue
Renal
Pleural effusion
Pericarditis
Raynaud's phenomenon
Abdominal pain
Neurological manifestation

30

SLE

Chronic progressive inflammatory connective tissue disorder- major organ failure
Exacerbation

31

SLE patho

Complexes invade organs directly or cause vasculitis, cutting off O2 supply
-----kidneys------

32

DLE

Affects skin only

33

SLE PLaquenil

Decreased absorption of UV light.
Skin lesions
Frequent eye exams

34

SLE chronic steroid treatment

Methotrexate
Azathioprine

35

SLE first drug approved in 60 years

Belimumab (benlysta)