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Flashcards in Test 3 *** Deck (16):
1

Leukemia

A group of malignant disorders affecting the blood and blood forming tissues of bone marrow, lymph system, spleen

2

Risks for leukemia

Abnormal chromosome
Exposure to ionizing radiation
Immune deficiencies
Down's syndrome

3

Acute myelogenous leukemia

25% of all leukemia
85% of acute leukemia in adults
Abrupt, dramatic onset
Serious infection or abnormal bleeding

4

Acute myelogenous leukemia

Uncontrolled proliferation of myeloblasts
Hyperplasia of bone marrow and spleen

5

Acute lymphocytic leukemia
ALL

Most common in children
10-15% of acute leukemia in adults
Immature lymphocytes proliferate in bone marrow
B-cell origin

6

Sings and symptoms of ALL

Bruise, bleeding, fever, nosebleeds, weakness, pain, CNS manifestations HA

7

Chronic myelogenous leukemia

Excessive mature neoplasticism granulocytes in bone marrow
Move to peripheral blood in massive numbers
Ultimately infiltrate liver and spleen

8

Phases

Chronic (mild sysmptoms)
Accelerated (rapid/severe- doesn't respond to Tx)
Blast phase( aggressive, METZ)

9

Chronic lymphocytic leukemia

Production and accumulation of functionally inactive but long lived lymphocytes
Bcell involvement

10

Complete goal

Physical exam, blood is normal

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Partial goal

Physical negative
Blood negative
Bone positive

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Molecular goal

All studies negative

13

Stages of therapy
Induction

Achieve rapid, complete remission
Severe bone marrow suppression with neutropenia

14

Consolidation

After remission is achieved
Intent is to cure
Single or repeated courses

15

Maintenance

PO chemo for 2-5 years

16

Drug

Gieevic
First line therapy for CML
+ philedephilia chromosome