Final Flashcards
Name the purines
Adenine and Guanine
Name the pyrimidines
Thymine, Cytosine, and Uracil
molecular make up of DNA and RNA
one or more phosphate groups, sugar, nitrogenous bases
difference between RNA and DNA
DNA: deoxyribose, double stranded, adenine pairs with thymine
RNA: ribose, single stranded, adenine pairs with uracil
There is normal biota in the
upper respiratory and GI tract
There are no biota in the
Accessory digestive organs/glands, lower respiratory, nervous and cardiovascular systems
process of replication
basically consists of a series of enzymes that separate the strands of the DNA molecule, copy one strand, and produce two daughter molecules
This enzyme will break the hydrogen bonds holding the two strands together, resulting in two separate strands (unzips the DNA)
helicase
This enzyme binds to each single strand of DNA to keep them apart
Single stranded binding protein
initiation of DNA synthesis requires a jump start or short RNA template manufactured by
RNA polymerase
adds nucleotides to the primer sequence and starts synthesizing new strands of DNA
DNA polymerase III
removes primer sequence through enzymatic action (cuts out RNA and replaces it with DNA)
DNA polymerase I
Joins or glues the Okazaki fragments together
ligase
synthesized from DNA to direct the synthesis of polypeptide chains (proteins)
mRNA
forms ribosomal subunits that together make up the ribosome
rRNA
functions to transfer amino acids from the cytoplasm to the ribosomes for placement in a protein molecule
tRNA
Beginning and end products of replication, transcription, and translation.
replication: DNA -> DNA, transcription: DNA -> mRNA, translation: mRNA -> protein
what is lysozyme?
enzyme in tears and saliva that break down the peptidoglycan in the cell wall of bacteria
How can the skin be inhibitory to microbes?
high lactic acid content of sweat and acidic pH and fatty content
How does the stomach defend against bacteria?
gastric juices that have a pH of about 1 - 3
general purpose phagocyte that are 1st in the inflammation process and primary component of pus
neutrophils
travel in the blood as phagocytes
monocytes
after monocytes leave the bloodstream they are transformed by various inflammatory mediator into these
macrophages
phagocytes recognize microorganisms as foreign by these
pathogen associated molecular patterns or PAMPs
these are used by host cells to recognize PAMPs
pattern recognition receptors or PRRs
first line of defense is
non-specific; barriers that block entry: skin and mucous membranes
second line of defense
non-specific; system of protective cells and fluids: inflammation, phagocytosis, and fever
third line of defense is
specificity and memory; acquired as each pathogen is encountered: B-cells and T-cells
what is a fever?
a systemic rise in body temperature; clinical def. = 100.5
body temperature is controlled by the
hypothalamus
what chemical causes a fever to occur?
pyrogens stimulate the hypothalamus to raise the bodies temp
benefits of a fever: (5)
lessens growth, inactivate microbe enzymes, increase phagocytosis, increase lysosome breakdown, make you feel like resting
dilation and permeability of blood vessels causing warmth, redness, and swelling
vasodilation
increase in leukocytes in blood at infection site
leukocytosis
when antibodies are passed from mother to offspring via the placenta or breast milk
naturally acquired passive immunity
produced when a person has and recovers from a disease
naturally acquired active immunity
when a person is vaccinated, they have this
artificially acquired active immunity
when antibodies are given to a person, for example, antibiotics
artificially acquired passive immunity
3 functions of helper T cells
they activate macrophages, B cells, and cytotoxic T cells
cytotoxic T cells lead to the destruction of
virus infected cells and cancer cells
cytotoxic T cells has which co-receptor and binds to which complex?
CD8 and binds to MHC I
helper T cells has which co-receptor and binds to which complex?
CD4 and binds to MHC II
2 types of progeny of B cells
plasma cells and memory cells
what cells release antibodies into the tissues and blood?
plasma cells
What cells are responsible for activating T helper cells?
APC
What cells are responsible for activating T cytotoxic cells?
T helper cells
what are the antigen presenting cells?
B cells, macrophages, and dendritic cells
these cells internalize and process antigens, presenting MHC II receptors that activate T helper cells
APC
Which cells express MHC I?
all nucleated cells have this complex. When infected with a virus, a cell will process it and send it to the MHC I.
difference between antigen and antibody
antigen is any foreign substance and antibodies are proteins produced in response to antigens
microorganisms that live on or in the human body
normal/resident biota
the generally good effect microbes have against intruder microbes
microbial antagonism
relationship that normal biota have with humans
commensal or mutualistic
exotoxins that lyse red blood cells
hemolysins
exotoxins that damage white blood cells especially neutrophils and macrophages
leukocidins
exotoxins that act on tissues of the nervous system to prevent muscle contraction or relaxation
neurotoxins
exotoxins that act on tissues of the gut
enterotoxins
toxic enzyme produced by Gram + bacteria and secreted into host tissue
exotoxins
Lipopolysaccharides that are part of the cell wall of gram negative bacteria are released when the cell dies or divides. this is an example of what?
endotoxins
5 stages of infectious disease
incubation, prodromal, invasive, decline, convalescence
Stage of infectious disease between infection and appearance of signs and symptoms
incubation period
Stage of infectious disease that is the short period during which nonspecific, often mild, symptoms occur
prodromal phase