Final: Blood Cells Cont.

Question 1

Leukemia location

Answer 1

Marrow or blood

Question 2

Lymphoma location

Answer 2

Lymphatic tissue

Question 3

Anemia is the MC initial feature of

Answer 3

Acute leukemia

Question 4

2 types of acute leukemia’s

Answer 4

Acute lymphoblastic leukemia

Acute myeloid leukemia

Question 5

Sudden and “stormy” onset are indicative of

Answer 5

Acute leukemia

Question 6

MC pediatric cancer

Answer 6

Acute lymphoblastic leukemia

Question 7

ALL MC diagnosed at

Answer 7

Age 3, later with T cell age 15

Question 8

Prognosis of ALL

Answer 8

80% cure rate

Question 9

Aggressive cancer of lymphoblastic that can be Pre-B or Pre-T

Answer 9

ALL

Question 10

MC form of ALL

Answer 10

Pre-B cell

Marrow/blood

Question 11

Cancer of mature B cells with immunosuppression

Answer 11

Chronic lymphocytic leukemia (CLL

Question 12

MC leukemia of adulthood

Answer 12

CLL

Question 13

CLL MC diagnosed at

Answer 13

Age 60

Males 2X

Question 14

CLL in ___ and survival is ___

Answer 14

Incurable

4-6 years

Question 15

Pancytopenia (cells displacing marrow) and hypogammaglobulinemia observed in

Answer 15

CLL

Question 16

Follicular lymphoma

Answer 16

Cancer of B cells in follicular center with nodular growths

Question 17

25% of adult NHLs are

Answer 17

Follicular lymphomas

Question 18

Centrocytes are ___ and are observed in ___

Answer 18

Lymphocytes with cleaved nuclei

Follicular Lymphoma

Question 19

Follicular lymphoma affects

Answer 19

Males and females equally

> age 50

Question 20

Follicular lymphoma is ___ and average prognosis is

Answer 20

Incurable

7-9 years

Question 21

40% of follicular lymphoma progress into

Answer 21

Diffuse B cell lymphoma (aggressive)

Question 22

85% of follicular lymphoma have ___, which causes what mutation

Answer 22

T(14;18)
BCL2 gene

Decrease B cell apoptosis

Question 23

Cancer of mature B cells constituting 5% of NHLs

Answer 23

Mantle cell lymphoma

Question 24

Mantle cell lymphoma MC diagnosed

Answer 24

Males

>50 years

Question 25

Mantle cell lymphoma is ___ and prognosis is

Answer 25

Incurable 4-6 years

Question 26

Mantle cell lymphoma involves what mutation

Answer 26

T(11;14) | Dysfunctional cyclins

Question 27

Mantle cell lymphoma is extranodal and common places include

Answer 27

Marrow Spleen Liver GI

Question 28

MC lymphoma of adulthood

Answer 28

Diffuse large B cell lymphoma 35% NHL cases

Question 29

Risks for diffuse large B cell lymphoma

Answer 29

EBV | Immunosuppression

Question 30

Diffuse large B cell lymphoma MC age

Answer 30

60 Any age (15% pediatric lymphomas)

Question 31

Diffuse large B cell lymphoma may invade ___ and without treatment it is

Answer 31

Any organ Rapidly fatal

Question 32

Cancer of B cells that classically affects African children

Answer 32

Burkitt lymphoma

Question 33

“Starry sky” histology involving B cell proliferation and apoptosis is observed in

Answer 33

Burkitt lymphoma

Question 34

Risks for burkitt lymphoma

Answer 34

EBV | Mutated MYC gene via t(8;14)

Question 35

Fastest growing human tumor

Answer 35

Burkitt lymphoma

Question 36

Burkitt lymphoma is MC extranodal and in Africa affects ___ and in US affects ___

Answer 36

Maxilla and mandible Abdomen, GI, ovaries

Question 37

Favorable prognosis and most children are cured is a feature of

Answer 37

Burkitt lymphoma

Question 38

Plasma cell cancer MC diagnosed in the elderly, age ___, this gender, and what ethnicity

Answer 38

Multiple myeloma Age 70 Males African

Question 39

Multiple myeloma creates a “____” feature

Answer 39

Punched out (osteolytic lesions)

Question 40

Renal failure due to multiple myeloma with what proteins

Answer 40

Myeloma nephrosis bence-jones proteins

Question 41

Diagnosis of multiple myeloma

Answer 41

Multifocal lytic lesions Bence-jones proteinuria M-spike on electrophoresis

Question 42

Neurological symptoms of multiple myeloma

Answer 42

HA Dizziness Tinnitus Confusion

Question 43

Lethal complications from multiple myeloma

Answer 43

Bacterial infections | Kidney failure

Question 44

MC sites for lytic lesions

Answer 44

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