Final Genomics (only quiz 5 material added) Flashcards Preview

Genomics/Pop Health Spring 2018 > Final Genomics (only quiz 5 material added) > Flashcards

Flashcards in Final Genomics (only quiz 5 material added) Deck (29)
Loading flashcards...
1

CYP4F2 --- if reduced function it does what to what drug?

reduces warfarin sensitivity

2

what gene is related to clopidogrel

CYP2C19

3

what gene is related to warfarin

CYP2C9 and VKORC1 and CYP4F2

4

what gene is related to statins

SLOCB1

5

what genotype is ultrarapid metabolizer for CYP2C19

*17

6

what genotype is poor metabolizer for CYP2C19

*2 and *3 (multiple 2 and 3 genes)

7

T or F: Clopidogrel has required genetic testing

nah, just recommended --- still not routinely performed before PCIs

8

what is warfarins MOA

Inhibits Vitamin K epoxide reductase 1
(VKORC1)

9

PK Of warfarin:
the ______ isomer is the active one

s isomer

10

Warfarin is eliminated by _______

CYP2C9

11

CYP2C9 *2 or *3 reduces warfarin clearance the most

*3 (reduces clearance 75-90%)

12

VKORC Haplotypes:
1639___>___
and
1173___>____

G>A

C>T

13

Largest doses of warfarin are needed when VKORC1 has
1639____
and
1173____

GG

CC

14

CYP4F2: results in less ______ for ______

vit. k; clotting factors

15

what types of patients would benefit from genetic testing --- in regards to warfarin

high risk patients for bleeding
and
pts who can't get INR checked all the time (way to get better guess on right dose

16

MOA of HMGCoA reductase inhibitors:
upregulate ________
decrease ________

LDL receptors

decrease LDL concentrations

17

SLOC1B1: transport drug into ______

liver

18

what SLOC1B1: mutations would increase statin myopathy risk

*5 and *15

19

CPIC reccomendations for Simvastatin 80 mg:
Avoid ____ mg dose of simvastatin (consistent with labeling)
Exception may be in a patient with a _______ genotype AND a history of tolerating the dose

80;
521TT

20

we know what is SNP is..what is SNV

Aberration seen in only one individual (not well characterized)
Occur at low frequency so not common

21

most cancer mutations are somatic or germline?

somatic!! (acquired throughout life... not inherited)

22

what are the two cancer genes

tumor supressor
and oncogene

23

For Simvastatin/CPIC Guidelines:

Max of ____ mg in patients with 521 CT and CC genotypes (i.e. *5 or *15 carriers)

20

24

For Simvastatin/CPIC Guidelines:
Max of 20 mg in patients with 521 CT and CC genotypes (i.e. *___ or *____ carriers)

*5; *15

25

For Simvastatin/CPIC Guidelines:
Max of 20 mg in patients with 521 ___ and ____ genotypes (i.e. *5 or *15 carriers)

CT;CC

26

For Simvastatin/CPIC Guidelines:

Routinely monitor ____ if…
521 CT and CC genotypes are present (i.e. *5 or *15 carriers) AND
20 or 40 mg simvastatin is being used

CK

27

For Simvastatin/CPIC Guidelines:

Routinely monitor CK if…
521 CT and CC genotypes are present (i.e. *5 or *15 carriers) AND
____ or___ mg simvastatin is being used

20 or 40

28

For Simvastatin/CPIC Guidelines:

Routinely monitor CK if…
521 ____ and ____ genotypes are present (i.e. *5 or *15 carriers) AND
20 or 40 mg simvastatin is being used

CT;CC

(T = safe/no myopathy problems, any C is increase myopathy risk)

29

All of the following statements are true regarding CYP4F2:

Metabolizes vitamin K to ______ metabolite
Reduced function results in ______ warfarin sensitivity
Its genotype contributes less to warfarin _______ than VKORC1
Reduced function (does/does not) alter warfarin pharmacokinetics

hydroxyl

decreased

dose variability

does not