Final; Hepatitis Virus Flashcards Preview

SP14 Microbiology > Final; Hepatitis Virus > Flashcards

Flashcards in Final; Hepatitis Virus Deck (37):
1

Where does the hepatitis primarily infect and replicate

in hepatocytes

2

The virus and host response causes

liver disease
acute infections
chronic infections

3

How is the hepatitis virus transmitted

fecal-oral
sexual
vertical (mother-->child)
parenteral (needle sticks, etc.)

4

Which forms of hepatitis are found in the US

A, B, and C
Delta and E are rare

5

What genome does hepatitis B have

dsDNA
with RNA intermediate

6

What is special about the hepatitis B genome

it is the smallest genome of the human viruses

7

What type of virion does the hepatitis B have

enveloped

8

What types of proteins does the hepatitis B contain

vision assembly
cell attachment
capsid
reverse transcriptase

9

True or False
The hepatitis B cannot be grown in cell culture

True

10

This is a template for transcription in hepatitis B

cccDNA

11

True or False
The hepatitis B does not require liver specific transcription factors

False; it does

12

The hepatitis B produces many what

empty particles; present in infected people

13

How long is the incubation period for hepatitis B

30-180 days

14

How is hepatitis B spread

sexual contact and drug use

15

What are the symptoms of hepatitis B

malaise, anorexia, vomiting, fatigue, cough, serum-like sickness
jaundice, elevated alanine transaminase levels

16

When would one recover from hepatitis B

approximately 3-4 months after the onset of jaundice

17

In what percentage of cases does hepatitis B manifest as a chronic disease

5%

18

What constitutes a chronic hepatitis B disease

presence in blood after 6 months
poor IgG response
sporadic episodes of hepatitis B
cirrhosis of the liver
increased risk for hepatocellular carcinoma

19

What is special about the hepatitis B vaccination

it was the first recombinant vaccine approved for the use in humans
it requires multiple injections
not effective against chronic infection

20

What are the treatments for chronic hepatitis B infection

interferon-α therapy
nucleoside analogs

21

The hepatitis D virus is rare in humans, but what is special about it

subviral agent
requires active HBV infection
RNA genome encodes a single protein

22

What type of genome does hepatitis C have

+ssRNA

23

What type of virion does hepatitis C have

enveloped

24

What proteins does hepatitis C contain

attachment and entry
core
various non-structural

25

Where is the genome of hepatitis C replicated

in the cytoplasm, the genome itself is the template for translation

26

What are the symptoms of a hepatitis C infection

milder symptoms than HBV

27

What percentage of hepatitis C infections become chronic and cause what

80%
extrahepatic disease

28

This is caused by hepatitis C and is when antibody/virus complexes deposit in other tissues eliciting an immune response and subsequent tissue damage

mixed cryoglobulinema

29

What are the treatment options for hepatitis C

no vaccine
interferon-α can reduce chances of chronic infection

30

How does one obtain an hepatitis A infection

ingestion of fecally contaminated food or water

31

What is the incubation period of an hepatitis A infection

15-40 days

32

What are the symptoms of an hepatitis A infection

consistent with other hepatitis infections but more severe in adults than in children

33

When does a hepatitis A infection resolve

approximately 8 weeks post infection

34

What are the treatment options for hepatitis A

a vaccine is available; killed/inactivated

35

What does a hepatitis E infection cause

foodborne and waterborne hepatitis
similar to HAV
infection can be life threatening for pregnant women

36

What are the treatment options for hepatitis E

there is no vaccine, but it is under development

37

Which hepatitis viruses cause chronic infections

B, C, and D