Final; Neurological Viruses Flashcards Preview

SP14 Microbiology > Final; Neurological Viruses > Flashcards

Flashcards in Final; Neurological Viruses Deck (38):
1

How are selected toga viruses and flaviviruses transmitted

via a vector; arthropod transmission

2

What are the most common vectors

mosquitoes
ticks

3

What are the most common reservoirs

birds
small mammals (rodents, etc.)

4

What does transmission require via a vector

replication within the vector

5

What is determined by the vector and reservoir habitat

geographic location of the disease/infection

6

What is the genome of the EEE and VEE viruses

+ssRNA

7

What is the virion of the EEE and VEE viruses

enveloped

8

How does the EEE and VEE viruses exit the cell

via budding

9

How are the EEE and VEE viruses transmitted

via the bite of an infected arthropod

10

Where in the body do the EEE and VEE viruses infect

it infects cells locally and/or carried by the Langerhans cells to the LN
it then replicates and releases into the bloodstream --> CNS

11

What is the incubation period of EEE

4 to 10 days

12

What are the symptoms and duration of the EEE systemic disease

chills, fever, malaise, arthralgia, myalgia
lasting 1-2 weeks; full recovery

13

What are the symptoms of EEE encephalitic disease

fever, headache, irritability, restlessness, vomiting, diarrhea, convulsons, and coma

14

How many cases of encephalitic EEE die

1/3 of the cases die from the disease 2-10 days after the onset

15

What happens to those who recover from encephalitic EEE

they have long term sequelae; seizures, personality disorders, paralysis

16

What are the prevention strategies for EEE and VEE

a single vaccine is available, but only provided for those at risk
there is no treatment
mosquito control and repellant

17

Where is EEE prevalent in the US

the more warm humid locations like the south and the eastern coastline

18

What is the incubation period for the west nile virus

2 to 14 days, most people (80%) are asymptomatic

19

What are the symptoms in those that get an infection of west nile virus

fever, headache, fatigue (in 20% of cases)
duration of 3-6 days

20

What disease from west nile is prevalent in <1% of all cases

neuroinvasive disease

21

What are the symptoms of neuroinvasive disease from west nile

aseptic meningitis, encephalitis, flaccid paralysis, altered mental state and tremors
50% of survivors have sequelae 1 year later

22

What are the prevention and control strategies of west nile

no vaccine
no treatment
mosquito control and repellant

23

Why is west nile more prevalent across the US than EEE or VEE

birds are the reservoir and are found more widespread across the US

24

What is the genome of the rabies virus

-ssRNA

25

What is the virion of the rabies virus

enveloped

26

True or False
Rabies can infect many different hosts

True; broad tropism

27

What dictates the abundance of transcripts and proteins of the rabies virus

the genome order

28

Binding of what triggers genomic replication of the rabies virus

of N to RNA

29

What does the rabies virus frequently produce

defecting interfering particles

30

How is rabies transmitted

via the bite on an infected animal; only 15% of bites cause the disease but 60% of those to the face or head

31

What are the reservoirs of rabies

bats
skunks
raccoons

32

Where is rabies common in developing countries

in dogs; a common source of human rabies

33

What is the incubation period of rabies

1-3 months
depends on the location of the bite

34

How does rabies spread through the body

it replicated locally util it finds a neuron then to the brain, then out to the peripherally and specifically the salivary glands

35

What are the symptoms of rabies

prickling or itching where bitten, fever, headache
hydrophobia; difficulty swallowing = foaming at the mouth
cerebral dysfunction, anxiety, confusions, delirium, hallucinations, insomnia

36

What is the outcome of rabies

Once the symptoms appear, disease is nearly always fatal; only 10 documented survivals

37

What is used to prevent rabies

vaccine available
post-exposure prophylaxis; administered ASAP

38

What is used to control rabies

vaccination of domestic animals
some countries are vaccinating wildlife