Fluoroquinolones

Question 1

Examples

Answer 1

Examples: 1st generation-Norfloxacin
2nd generation Ciprofloxacin
3rd generation-Levofloxacin

Question 2

MOA:

Answer 2

Inhibit replication of DNA by interfering with action of DNA gyrase enzyme 🡺DNA synthesis inhibitor (Bactericidal)

Question 3

Adverse reactions:

Answer 3

Peripheral neuropathy
Seizures
Allergic reactions (rare)
Diarrhea(Clostridium difficile-associated)

Question 4

Drug interactions:

Answer 4

Absorption significantly reduced by
1. Aluminium and
2. Magnesium antacids

Interferes with metabolism of: Theophylline
Caffeine and
Warfarin