Fungi Flashcards
(56 cards)
KOH prep
Dermatomycoses
Red patches with clear borders, sometimes ring like appearance
Dermatomycoses
Dermatomycoses uses what to invade skin?
keratinases
ROSES
Sporotrichosis
What does sporotrichosis look like under microscope?
Flowerette
Tumor like swollen lesions that form draining sinus tracts and SULFUR granules
Myetoma
Bird/Batz
Histoplasmosis Capsulatum
Wind/SW USA
Coccidioidmycosis
ICH to SE asia
Pencilliosis
Bread mold
Zygomycosis
Zygomycosis vs. aspergillosis?
zygo 90
asp 45
Catheters, biofilm?
Candidiasis
Pigeon, encapsulated so india ink, CNS
Cryptococcosis
How is pneumocytosis difefrent than other fungi?
- Susceptible to antibacterial agents
- Lacks ergosterol
- Not susceptible to amphotericin B (which targets ergosterol)
What population gets PCP?
Only ICH
o Binds sterols and punches wall in membrane
o Nephrotoxic
o Lipid form (Ambisome) less toxic doe
Amphotericin B
o P450 inhibitors that block conversion of lanosterol to ergosterol, interfering with fungal cell membrane synthesis
Azole
which of the azole has SE of visual disturbance?
Vorixonazole
o Inhibits synthesis of 1,3-D-glucan, component of fungal cell wall
o Few SE because enzymatic pathway not found in humans
o Candida and Aspergillus treatment
Echinocandins
o DNA synthesis inhibitor
o Used in combo with amphotericin B
o Treats cryptococcal meningitis and some cindida
o SE: fatal bone marrow suppression
Flycytosine
o Interfered with ergosterol synthesis by inhibiting fungal squalene epoxidase
o Only achieves concentrations in skin and nails
o Tx for onychomycosis and fungal dermatophyte infections
Terbinadine
Dimorphic Fungi?
Histoplasmosis Capsulatum
Blastomycosis dermatitidis
Coccidiomycosis
Paracoccidioidomycosis
Sulfur granules
P. Boydii
Traumatic implantations
P. Boydii or Sporotrichosis
