Virology Flashcards
(160 cards)
1
Q
DNA replication in nucleus. Exception to this rule?
A
poxvirus
2
Q
temporal lobe?
A
HSV 1
3
Q
multinucleated giant cells?
A
HSV
4
Q
Hepatic whitlow?
A
HSV
5
Q
Tx for HSV?
A
Acyclovir
6
Q
Chicken pox rash starts where to where?
A
Face to trunk
7
Q
Dew drops on rose petal
A
chicken pox
8
Q
vesicular lesion on single dermatome
A
shingles
9
Q
herpes zoster opthalmicus
A
VZV (chicken pox-shingles)
10
Q
VZV treatment?
A
Acyclovir
11
Q
infect B lymphocytes but on smear, weird T lymphocytes
A
EBV
12
Q
Mono
A
EBV
13
Q
rash following exposure to amoxicillin
A
EBV
14
Q
Burkitt lymphoma
A
EBV
15
Q
Roseola
A
HHV6
16
Q
B cell infection
A
HHV8
17
Q
Kaposi sarcoma
A
HHV8
18
Q
mono symptoms but negative monospot?
A
CMV
19
Q
CMV organ donor/recipient?
A
D+/R-
20
Q
Major complication of CMV in HIV patients?
A
CMV retinitis
21
Q
CMV treatment?
A
Gancyclovir
22
Q
Conjunctivitis
A
Adenovirus
23
Q
clathrin coat
A
adenovirus
24
Q
slapped cheek
A
parvovirus
25
lacy reticular rash in kids, seronegative arthritis in adults
parvovirus
26
aplastic crisis
Parvovirus
27
parvovirus dx?
IgM
28
PLantar warts
1/4
29
genital warts
6/11
30
cervical carcinoma
16/18
31
E6 inactivates? E7 inactivates?
p53, Rb
32
liver transplant
BK
33
JC symptom?
multifocal leukoencephalopathy
34
Smallpox rash spread?
face then to soles of feet/palms
35
praire dogs viral infection
monkeypox
36
umbilicated skin lesion
molluscum contagiosum
37
sheeps/goats
orf
38
RNA viral replication in cytoplasm. What's the exception?
influenza
39
```
F, G
Injures cell by direct cytotoxicity
Syncytia formation by microscopy
Peaks in winter
Most common cause of severe respiratory disease in infants
Tx? Ribavirin inhibits RDRP
```
RSV
40
Similar to RSV but milder
Peaks in march (RSV peaks in Jan)
Older population but less common than RSV
Human metapneumovirus
41
Parainfluenza glycoproteins?
Hn and F
42
Parainfluenza strain that causes croup?
1
43
What strain of parainfluenza causes bronchiolitis and pneumo?
3
44
Mumps glycoprotein
HN and F
45
Measles glycoprotein?
F
46
Vitamin A deficiency
Measles
47
Measles symptoms
4 C: cough, coryza, conjunctivitis, koplick
48
SSPE
complication of measles
49
most common cause of death by measles?
pneumo
50
segmented genomes?
influenza, arenaviridae, (lymphocytic virus and lassa), rotavirus
51
Influenza glycoprotein?
H and N
52
Sialic acid?
Influenza
53
M2 inhibitors for influenza?
amantadine and rimantidine
54
Neuramidase inhibitors of influenza
oseltamivir, zanamivir
55
bullet shaped
rabies
56
bats
rabies
57
rabies testing?
biopsy of neck because high viral titers in saliva
58
negri bodies
rabies
59
filoviruses?
ebola/marburg
60
arenaviridiae?
lymphocytic choriomeningitis virus and lassa
61
rodent urine
lymphocytic chrotiomeningitis
62
bunyaviridae
lacross encephalitis, hantavirus
63
forest mammal-mosquito cycle
lacrosse
64
rodent waste
hanta
65
herpangina (grey-white vesicles in tonsils)
Cox A enterovirus
66
hand foot mouth disease
Cox A
67
Cox B symptom?
myo-/pericarditis
68
Devil's grip
Enterovirus
69
norovirus causes lesions where?
jejunum
70
3 stages of SARS
1. fever and viral symptoms
2. fever and SOB
3. ARDS
71
blueberry muffin rash
Rubella (and some CMV congenital cases)
72
young hispanic mama
rubella
73
triad of rubella?
deafness. PDA. blindness
74
WEE vs EEE?
WEE: asymptomatic to encephalitis
EEE: fever, myalgia, encephalitis
75
break bone fever?
dengue
76
flaccid paralysis
West Nile (and polio)
77
only double stranded RNA
Rotavirus
78
Rotavirus outer capsid protein and inner?
VP4 and 7 are outer
| VP6 is inner
79
infantile watery diarrhea
rotavirus
80
DNA double E
```
HSV
VZV
EBV
CMV
HHV6-8
Hep B
```
81
DNA double noE
Adenovirus
82
DNA single NoE
Parvovirus
83
DNA Single E
HPV
| JC/BK
84
DNA Complex
smallpox
monkeypox
orf
molluscum contagiosum
85
RNA neg E
```
RSV
parainfluenza/influenza
MM
rabies
Filo (ebola/marburg)
Arena (lympho, lassa)
Bunya (Lacrosse, Hanta)
Hep B
```
86
RNA positive noE
```
Polio
Entero
Human paredovirus
norovirus
Hep E/A
```
87
RNA double
Rotavirus
88
RNA positive E
```
SARS/nonSARS
Toga (rubella, WEE, EEE)
Yellow fever
Dungue
St. Louis encephalitis
West Nile
Hep C
HIV
```
89
All DNA viruses enveloped EXCEPT
Adenovirus, parvovirus, papillomavirus, polyomavirus (JC, BK)
90
Painful hand vesicle that can occur in healthcare workers
HSV1
91
Attacks predominantly erythrocytes (2⁰ replication)
Parvovirus
92
Replicates in jejunum and within 24 hours gets blunted villi, 6 mo. Immunity
Norovirus
93
Monospot - mononucleosis, from blood transfusion products (R-/D+ at risk in solid organ and R+/D- for peripheral ST), see owl’s eye
CMV
94
Most people have Ab to these DNA viruses, only in ICH
JC/PK
95
High morbidity in pregnant women, no tx, no chronic state, no vaccine
Hep E
96
Temporal lobe encephalitis
HSC1
97
All DNA viruses double stranded except
Parvovirus
98
Requires presence of HBV to replicate, either coinfection or superinfection: icterus, declining LFT, parental/sexual/mucous membrane/maternal-fetal
Hep D
99
ICH hemorrhagic cystitis and renal transplant rejection
BK
100
Usually asymptomatic, but if not gets encephalitis and flaccid paralysis; from mosquito (birds/horses), blood transfusion and maternal-fetal
WNV
101
f/o (water, food), hog farmers
Hep E
102
Progressive multifocal leukoencephalopathy (reactivation in ICH); demyelination of CNS, cognitive disturbances, visual field defects
JC
103
All DNA viruses linear EXCEPT
Hepadnavirus, polyomavirus (JC, BK), Papillomavirus
104
Jaundice + faint maculopapular rash (fever resolves before rash), arthritis
Rubella
105
Ribozyme
Hep B
106
Replicates in cooler 33 degrees C of nose and upper airway
Rhinovius
107
only live attenuated vaccine to give to HIV
MMR
108
Binds ICAM-1 in URT epithelial cells
Rhinovirus
109
Warthin-Finkeldey cells (multinucleated giant cells with inclusion bodies in nucleus and cytoplasm)
Measles
110
Picornavirus, no carrier state, incubation short, vaccine available
Hep A
111
Also known as rubeloa (Roseola is HHV6)
Measles
112
5 most common pediatric rashes
Measles, Rubella, Scarlet fever, Roseola, Parvovirus
113
Disease in young infants, vitamin A deficient, cell mediated immune deficient
Measles
114
Latent in mononuclear cells with intracranial calcifications
CMV
115
Jaundice, HSM, seizures, MR, retinitis in babies
Congenital CMV
116
1st disease: fever/bone aches 2nd disease/babies severe with hemorrhagic fever (Aedes spp. Mosquito)
Dengue
117
Viral meningitis, herpangia, hemorrhagic conjunctivitis
Enterovirus
118
RUQ pain, fever, HSM, dark urine, light stool
Hepatitis
119
RNA helical enveloped SS – seg
Bunya, Arena, Influenza
120
DS DNA circular, immigrants from Asia, has own RdDp
Hep B
121
Hepatitis in traveler, contaminated food/water, f/o
Hep A
122
Negri bodies
Rabies
123
Ampicillin rash
EBV
124
Acute hepatitis or chronic infection, HCC, extrahepatic syndromes (parental, sexual, blood transfusion, transplant, IVDU)
Hep C
125
Often associated with daycares, pools: direct contact, f/o, aerosol
Adenovirus
126
Mild disease to high fever with jaundice (hepatitis) oliguria, proteinurea, shock, Aedes Eqgypti mosquito
Yellow fever
127
Organisms that cross the placenta
TORCHES: Toxoplasmosis, Rubella, CMV, Herpes/HIV, Syphilis
128
Meningitis, encephalitis, fever, sever in elderly, Culex mosquito (from birds)
St. Louis encephalitis
129
Replicate in T cells (CXCR4) or MO (CCR5) with p24 nucleocapsid and pol (integrase, RT, protease)
HIV-1/2 (attach via env protein (gp120) and CD4R + coreceptors (CXCR4/CCR5), fusion of viral envelope (gp41⇒virus enters), RT (RNA→DNA), integrase (into DNA genome), viral protein production and protease that cleaves it, DC function as APC to transport to lymphoid tissue
130
Sporatic encephalitis in neonates
HSV
131
Retinitis in AIDS
CMV
132
All RNA viruses linear EXCEPT
Arenavirus, bunyavirus, deltavirus (CIRCULAR)
133
Reye's Syndrome caused by
Influenza
134
Used to monitor response in HIV tx
HiV RNA viral load
135
All children infected by 2, most common cause of severe respiratory illness (bronchiolitis and pneumonia)
RSV
136
Used to optimize antiretroviral tx in HIV
HIV genotypic test
137
Was confined to Africa until prairie dog issue, fever, vesicular rash, LN
Monkeypox
138
Most common non-strep pharyngitis
Adenovirus
139
Herpangina
Cox A (enterovirus)
140
Segmented genome
Influenza, Rotavirus, LCV, Lassa, Hanta, LaCrosse Encephalitis (I'LLL HR)
141
Nasal drainage, wheezing, most common cause of respiratory illness in children (0-5mo); syncytia formation
RSV
142
Condyloma acuminata
HPV: Icosahedral, Nonenveloped, DS circular): Koilocytes with proteins E6 (p53) and E7 (RB)
143
Febrile illness, flu-like with leukopenia and thrombocytopenia, meningitis, encephalitis→robovirus
LCMV
144
Most common viral STD
HPV
145
Second common cause of bronchiolitis/pneumonia in infancy
PIV3
146
Eczema vaccinatum due to vaccine
Smallpox vaccine (eradicated due to 1 serotype, no carrier, and no animal reservoirs)
147
F (viral fusion) surface protein which cause multinucleated giant cells to form
Paramyxovirus (RSV, PIV, hMPV, Mumps, Measles)
148
Hydrops fetalis + cardiac failure, edema, ascites, pleural effusion
Parvovirus B19 (I, Nonenveloped, SS – linear): transplacental
149
Neurologic disease (hydrophobia, hallucinations, flaccid paralysis)
Rabies
150
Mosquito with reservoir forest mammals (circular genome, RNA)
CA encephalitis
151
LAV
Varicella/zoster, MMR, Influenza, Polio (sabin), Rotavirus, Yellow Fever
152
Tropism for the placenta/fetus; serious congenital illness
Rubella
153
Inactivated Virus
Influenza, Polio (salk), Rabies, HepA
154
Rodent vector
LCV, Lassa, Hanta
155
Diagnosed by chest X-ray, has F and G virulence factors
RSV
156
Can cause aplastic crisis (hemolytic anemia)
Parvovirus
157
Monkey reservoir
Marburg
158
Warts in the larynx
HPV (can cause airway swelling, hoarseness and secondary bacterial pneumonia)
159
Pharyngitis, keratoconjunctivitis, acute hemorrhagic cystitis, pharyngoconjunctivitis, common cold, gastroenteritis
Adenovirus
160
Rash that affects palms/soles
R. Ricketssii
secondary syphllis
smallpox
