Fungi causing internal (systemic) mycoses

Question 1

__________ is the most common fungal cause of systemic infection

Answer 1

Aspergillus fumigatus

Question 2

T/F isolation of A. fumigatus is sufficient evidence of infection

Answer 2

False. need to see organism in the lesion or have repeat isolation

Question 3

In cattle aspergillus causes:

Answer 3

pulmonary and cutaneous infection, abortions, rumenitis, gastritis, mastitis

Question 4

In horses aspergillus is associated with:

Answer 4

abortion, guttural pouch infection, diarrhea in foals

Question 5

In dogs __________ is assocated with aspergillus

Answer 5

frontal sinus infection

Question 6

Asperigillus causes __________ in cats

Answer 6

pulmonary disease

Question 7

__________ is the cause of respiratory disease in captive penguins and brooder pneumonia

Answer 7

Aspergillus

Question 8

__________ causes crop mycosis in commercial turkey flocks

Answer 8

aspergillus

Question 9

How is aspergillus transmitted

Answer 9

usually via feed in commercial poultry

inhalation/ingestion of spores are major routes

animals must common incontact with large numbers of spores are be immunocompromised to exhibit disease

Question 10

__________ __________ has a predelection for the brain and meninges, neurotrpic fungus

Answer 10

Cryptococcus neoformans

Question 11

Cryptococcus neoformans is associated with __________ (habitat)

Answer 11

dessicated pigeon feces

associated with trees w/ pockets of rotted material

Question 12

__________ __________ fungus in cattle may infect mammary tissue and adjacent LN

Answer 12

Crytococcus neoformans

Question 13

__________ __________ in horses causes nasal discharge, respiratory distress due to nasal granuloma fomraiton

Answer 13

Cryptococcus neoformans

Question 14

__________ examination for thick capsule in very important for C. neoformans

Answer 14

India Ink

Question 15

__________ lserodiagnosis detects antigen or serum CSF to C. neoformans

Answer 15

latex slide agglutination

Question 16

__________ __________ is the cause of North American blastomycosis, a chronic granumlomatous and suppurative infection of humans and domestic animals

Answer 16

Blastomyces dermatitidis

Question 17

__________ __________ is a saprophyte important in the Ohio, Missouri, and Mississippi River valleys

Answer 17

Balstomyces dermatidis

Question 18

Blastomyces dermatidis is transmitted via:

Answer 18

inhalation of spores

Question 19

T/F the pulmonary form of Blastomyces dermatidis disseminates via hematogenous route and produces granulomatous infection of skin and internal organs

Answer 19

True

Question 20

__________ __________ causes valley fever and chronic disseminated granulomatous lesions

Answer 20

Coccidiodes immitis

Question 21

__________ __________ produces hyphae that are readily aerosolized and very dangerous for lab workers

Answer 21

Coccidiodes immitis

Question 22

__________ __________ is edemic to the desert country of the SW USA and San Joaquin Valley of California

Answer 22

Coccidiodes immitis

Question 23

C. immitis causes __________ in cattle

Answer 23

benign disease of the LN of the chest

Question 24

C. immitis causes __________ in dogs

Answer 24

granulomatous lesions w/ lungs as primary site, disseminates and has chronic course with debilitation and death

Question 25

C. immitis causes __________ in humans

Answer 25

Valley fever, pulmonary form, may disseminate, occasionally skin lesions are primary site

Question 26

__________ is used to treat C. immitis infections

Answer 26

Amphotericin B

Question 27

T/F Cattle are the most common domestic animal affected by Coccidiodes immiis

Answer 27

FALSE its dogs

Question 28

__________ __________ produces a generalized disease involving the reticulo-endothelial system

Answer 28

Histoplasma capsulatum

Question 29

__________ and __________ are the two kinds of spores observed with Histoplasma capsulatum

Answer 29

Microconidia Tuberculate chlamydospores

Question 30

inhalation of spores which are then phagocytized and soread to the RES via __________

Answer 30

mononuclear cells

Question 31

__________ __________ us the cayse of epizootic lymphangitis or African farcy in horses and mules

Answer 31

Histoplasma capsulatum var farciminosum

Question 32

__________ is and endemic soil saphrophyte in parts of africa

Answer 32

Histoplasma capsulatum var farciminosum

Question 33

__________ may be used to treat Histoplasma capsulatum var farciminosum

Answer 33

Na Iodide

Question 34

__________ is a general term used to describe infections caused by zygomycetesm often take the form of granulomatous and ulcerative lesions, frequently in the lymphnodes and respiratory and alimentary tracts

Answer 34

Zygomycosis

Question 35

What are the 3 genera of Zygomycosis and whar is special about them morphologically?

Answer 35

Mucor, Rhizopus, Absidia see coarse, non septate, branching hyphae w/ rounded sporangia when observed on LPCB mounts in culture they all have sporangium attached to sporangiophore

Question 36

__________ is a subcutaneous infection caused bu a number if dermatiaceous fungi, reported from dogs, horses and humans

Answer 36

CHromomycosis

Question 37

What species are involved in chromomycosis?

Answer 37

Hormodendrum, Cladosporium, are most common

Question 38

Pathogenesis of chromomycosis?

Answer 38

infection via wounds/abrasions, nodular, frequently ulcerative lesions of thef eet and legs w/ regional granulomatous lymphandenitis

Question 39

__________ is a localized swollen lesion consisting of granulomas and abcesses which suppurate and drain through sinus tracts, usually involve skin, sub q, fascia and bone

Answer 39

Mycetoma

Question 40

__________ __________ caused by species of the genus Actinomyces

Answer 40

Actinomycotic mycetomas

Question 41

__________ __________ is caused bt atleast 13 different species of fungi reported infrequently from animals

Answer 41

Eumycotic mycetomas

Question 42

__________ , __________ and __________ are organisms that cause mycetomas

Answer 42

Allescheria, Curvualria, Helminthisporium