Flashcards in G6PD case Deck (12)
If a person is immunocompromised what can occur?
Possible pneumonia (tachypnea and lung sounds)
If a person has hypoxia, cough, fatigue and dyspnea they could have.....
What organisms are responsible for pneumonia?
Pneumocystis, nocardia, CMV, klebsiella, S. pneumo, mycoplasma, haemophilus, pseudomonas, S. aureus
3 opportunistic pathogens associated with pneumonia in the immune-compromised pt.
Pneumocystis, CMV, nocardia, mycobacterium avium intracellulare
What diagnostic test would be done to identify pneumocystis jirovecii?
Methenamine silver stain
What is the mechanism for sulfadrugs?
Inhibit folic acid synthesis: TMP acts on dihydrofolate reductase (stops dihydrofolic acid from converting to tetrahydrofolic acid) and SMX acts on dihydropteroate synthase (stops PABA from converting to dihydrofolic acid)
What is the biochemical pathway in which the G6PD enzyme functions?
Goes through the PPP
What enzyme reacts and catalyzes G6PD?
Oxidative step that produces NADPH
Why would a deficiency in G6PD contribute to hemolytic anemia?
Oxidative damage inside the RBCs, they don’t have nuclei and can’t turn on gene transcription to repair problems
What are the morphological features of a blood smear from a G6PD deficient pt?
Presence of Heinz bodies on the blood smear
How does the pentose phosphate pathway work to protect erythrocytes from damage?
PPP produces NADPH as a byproduct, which is needed to maintain the glutathione pool for the RBCs