Gastro2 Flashcards
(33 cards)
Alarm GI symptoms that reuire urgent referral to gastro?
Symptom onset after 50 years of age
Severe or progressively worsening symptoms
Unexplained weight loss
Nocturnal diarrhoea
Family history of organic gastrointestinal disease
Rectal bleeding or melaena
Unexplained iron deficiency anaemia
Positive faecal occult blood test
Palpable abdominal mass or lymphadenopathy
What are the Rome IV criteria for diagnosing IBS
- Symptoms have no biochemical or structural cause
- Recurrent abdominal pain for ≥1 day per week in the past three months associated with two or more of the following:
* Related to defecation*
Onset associated with a change in stool frequency
Onset associated with change in stool form
What are the four subtypes of IBS
- IBS with diarrhoea (IBS-D)
- IBS with constipation (IBS-C)
- IBS with mixed symptoms of constipation and diarrhoea (IBS-M)
- unsubtyped IBS (IBS-U).
How is IBS diagnosed
On basis of Rome IV criteria and absence of alarm symptoms
Whats the relationship between a functional gastrointestinal disorder and comorbid psych issues?
High correlation
IBS-C is closely correlated to psychological trauma/incl childhood abuse
If theres evidence of comorbid psych issues - specialised counselling is recommended
Management of IBS
- Education
- Diet Avoid high FODMAP foods/Diet high in soluble fibre
- Cognitive behavioural therapy or psych counselling
- Physical activity - as per guidelines
- Low dose TCA meds and/or spasmolytic agent
IF refractory consider a HYDROGEN breath test looking for small intestinal bacterial overgrowth (SIBO)
(methane on breath testing is more common in patients with C- IBS)
How would you treat SIBO?
2 weeks of Aug DF bd
Symptoms of GORD and DDx
- heart burn
- retrosternal rising discomfort
- Regurgitation
- Minor dysphagia (Can be associated with peptic stricture)
DDx
- Eosinophillic oesaphagitis (Atopic history and intermittent dysphagia is prominent)
- Atypical chest pain
Alarm symptoms - peristent vomiting, anaemia, haematemesis and malaena
Non pharmacological mx of GORD
reducing consumption of fat, protein, coffee, alcohol, chocolate, and acidic and spicy food
reducing meal sizes
avoiding food and drinks within 2–3 hours of lying down, exercise or bedtime
drinking fluids between meals
stopping smoking
limiting provoking foods and drinks.
Elevate head of bed
Weight reduction
Indications for endoscopy in GORD
Endoscopy is only recommended if the patient exhibits indications of alarm features, including
- significant dysphagia,
- odynophagia,
- haematemesis,
- melaena,
- iron deficiency anaemia,
- weight loss
- or persistent vomiting.
- Endoscopy is also recommended if there is an inadequate response to standard PPI doses after four to eight weeks.
When is H Pylori testing recommended in GORD
Testing for Helicobacter pylori is recommended if reflux symptoms overlap with dyspepsia, epigastric discomfort, pain and bloating. If detected, eradication therapy is recommended.
When would you scope someone with H Pylori
Endoscopy is not recommended for patients who test positive for H. pylori unless
- alarm symptoms are present,
- if there is a first-degree relative with gastric cancer
- or the patient was born in a region with high gastric cancer prevalence.
Aside from alarm symptoms or fhx when else is endocsopy indicated
endoscopy is indicated if diagnostic clarification is required – for example, when reflux is thought to be responsible for dental erosions, globus sensation, sore throat, vocal hoarseness, laryngitis, cough and wheeze. These latter symptoms are frequently attributed to GORD even though there is an overdiagnosis of GORD as the major contributing factor for these symptoms
WHat happens when you add H2RA to PPI
tachyphylaxis - reduced effect over time
this can be attenuated by alternate weekly use
What are surveillance requirements for Barretts
treatment with PPIs to control reflux symptoms
surveillance endoscopy every three to five years for short-segment disease (<3 cm)
surveillance endoscopy at two-yearly to three-yearly intervals for long-segment involvement, which has greater risk of progression to cancer.
What is Barretts oesophagus
Barrett oesophagus is characterised by the replacement of the distal squamous oesophageal mucosa with columnar mucosa containing histological intestinal metaplasia. While considered pre-malignant, the risk of progression to high-grade dysplasia or cancer is very low (0.2% per annum). The diagnosis of Barrett oesophagus likely causes disproportionate anxiety and excessive surveillance.
Potential side effects of long term PPI
kidney disease, dementia, osteoporosis, pneumonia and Clostridium difficile infections
with the only well-proven side effect being an increase in risk of enteric infections such as travellers’ diarrhoea.1 Other possible long-term risks such as increased fracture incidence and renal insufficiency have been raised by some case-control studies, but these studies have been unable to rule out confounders.
what are some reasons for fialure to respond for PPIs
Oesophageal hypersensitivity and functional heartburn are functional disorders resembling reflux that do not respond to further acid suppression (ph monitoring correlates symptoms to reflux events). Various motility disorders can also present with reflux-like symptoms. Identification of these conditions (eg with oesophageal manometry for motility ) indicates a likely poor response to surgery. Thus, a specialist assessment is recommended prior to referral for anti-reflux surgery.
Most important lifestyle factor in GORD
WEIGHT REDUCTION!
Aspree trial results on CV risk and aspriin
Almost 20,000 participants were randomised to receive either 100 mg aspirin daily or a placebo for almost five years. The rate of cardiovascular events in those receiving aspirin was almost identical to those given placebo. However, the aspirin group had approximately a 40% higher rate of major haemorrhage.1
If you’ve had a bleed on NSAID how likely are you to have a second bleed?
Patients who developed a bleeding ulcer while taking NSAIDs or low-dose aspirin are at least 10 times more likely to have a subsequent ulcer bleed if they recommence NSAIDs or aspirin.1
If prescribing an NSAID in a patient with increased GI bleeding risk ?
COX 2 inhibitor (Eg celcoxib 100mg bd)
+
PPI (20 or 40mg)