Gastro2 Flashcards

(33 cards)

1
Q

Alarm GI symptoms that reuire urgent referral to gastro?

A

Symptom onset after 50 years of age

Severe or progressively worsening symptoms

Unexplained weight loss

Nocturnal diarrhoea

Family history of organic gastrointestinal disease

Rectal bleeding or melaena

Unexplained iron deficiency anaemia

Positive faecal occult blood test

Palpable abdominal mass or lymphadenopathy

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2
Q

What are the Rome IV criteria for diagnosing IBS

A
  1. Symptoms have no biochemical or structural cause
  2. Recurrent abdominal pain for ≥1 day per week in the past three months associated with two or more of the following:
    * Related to defecation*

Onset associated with a change in stool frequency

Onset associated with change in stool form

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3
Q

What are the four subtypes of IBS

A
  1. IBS with diarrhoea (IBS-D)
  2. IBS with constipation (IBS-C)
  3. IBS with mixed symptoms of constipation and diarrhoea (IBS-M)
  4. unsubtyped IBS (IBS-U).
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4
Q

How is IBS diagnosed

A

On basis of Rome IV criteria and absence of alarm symptoms

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5
Q
A
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6
Q

Whats the relationship between a functional gastrointestinal disorder and comorbid psych issues?

A

High correlation

IBS-C is closely correlated to psychological trauma/incl childhood abuse

If theres evidence of comorbid psych issues - specialised counselling is recommended

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7
Q
A
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8
Q

Management of IBS

A
  1. Education
  2. Diet Avoid high FODMAP foods/Diet high in soluble fibre
  3. Cognitive behavioural therapy or psych counselling
  4. Physical activity - as per guidelines
  5. Low dose TCA meds and/or spasmolytic agent

IF refractory consider a HYDROGEN breath test looking for small intestinal bacterial overgrowth (SIBO)

(methane on breath testing is more common in patients with C- IBS)

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9
Q

How would you treat SIBO?

A

2 weeks of Aug DF bd

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10
Q

Symptoms of GORD and DDx

A
  1. heart burn
  2. retrosternal rising discomfort
  3. Regurgitation
  4. Minor dysphagia (Can be associated with peptic stricture)

DDx

  • Eosinophillic oesaphagitis (Atopic history and intermittent dysphagia is prominent)
  • Atypical chest pain

Alarm symptoms - peristent vomiting, anaemia, haematemesis and malaena

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11
Q

Non pharmacological mx of GORD

A

reducing consumption of fat, protein, coffee, alcohol, chocolate, and acidic and spicy food

reducing meal sizes

avoiding food and drinks within 2–3 hours of lying down, exercise or bedtime

drinking fluids between meals

stopping smoking

limiting provoking foods and drinks.

Elevate head of bed

Weight reduction

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12
Q

Indications for endoscopy in GORD

A

Endoscopy is only recommended if the patient exhibits indications of alarm features, including

  1. significant dysphagia,
  2. odynophagia,
  3. haematemesis,
  4. melaena,
  5. iron deficiency anaemia,
  6. weight loss
  7. or persistent vomiting.
  8. Endoscopy is also recommended if there is an inadequate response to standard PPI doses after four to eight weeks.
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13
Q

When is H Pylori testing recommended in GORD

A

Testing for Helicobacter pylori is recommended if reflux symptoms overlap with dyspepsia, epigastric discomfort, pain and bloating. If detected, eradication therapy is recommended.

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14
Q

When would you scope someone with H Pylori

A

Endoscopy is not recommended for patients who test positive for H. pylori unless

  1. alarm symptoms are present,
  2. if there is a first-degree relative with gastric cancer
  3. or the patient was born in a region with high gastric cancer prevalence.
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15
Q

Aside from alarm symptoms or fhx when else is endocsopy indicated

A

endoscopy is indicated if diagnostic clarification is required – for example, when reflux is thought to be responsible for dental erosions, globus sensation, sore throat, vocal hoarseness, laryngitis, cough and wheeze. These latter symptoms are frequently attributed to GORD even though there is an overdiagnosis of GORD as the major contributing factor for these symptoms

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16
Q

WHat happens when you add H2RA to PPI

A

tachyphylaxis - reduced effect over time

this can be attenuated by alternate weekly use

17
Q

What are surveillance requirements for Barretts

A

treatment with PPIs to control reflux symptoms

surveillance endoscopy every three to five years for short-segment disease (<3 cm)

surveillance endoscopy at two-yearly to three-yearly intervals for long-segment involvement, which has greater risk of progression to cancer.

18
Q

What is Barretts oesophagus

A

Barrett oesophagus is characterised by the replacement of the distal squamous oesophageal mucosa with columnar mucosa containing histological intestinal metaplasia. While considered pre-malignant, the risk of progression to high-grade dysplasia or cancer is very low (0.2% per annum). The diagnosis of Barrett oesophagus likely causes disproportionate anxiety and excessive surveillance.

19
Q

Potential side effects of long term PPI

A

kidney disease, dementia, osteoporosis, pneumonia and Clostridium difficile infections

with the only well-proven side effect being an increase in risk of enteric infections such as travellers’ diarrhoea.1 Other possible long-term risks such as increased fracture incidence and renal insufficiency have been raised by some case-control studies, but these studies have been unable to rule out confounders.

20
Q

what are some reasons for fialure to respond for PPIs

A

Oesophageal hypersensitivity and functional heartburn are functional disorders resembling reflux that do not respond to further acid suppression (ph monitoring correlates symptoms to reflux events). Various motility disorders can also present with reflux-like symptoms. Identification of these conditions (eg with oesophageal manometry for motility ) indicates a likely poor response to surgery. Thus, a specialist assessment is recommended prior to referral for anti-reflux surgery.

21
Q

Most important lifestyle factor in GORD

A

WEIGHT REDUCTION!

22
Q

Aspree trial results on CV risk and aspriin

A

Almost 20,000 participants were randomised to receive either 100 mg aspirin daily or a placebo for almost five years. The rate of cardiovascular events in those receiving aspirin was almost identical to those given placebo. However, the aspirin group had approximately a 40% higher rate of major haemorrhage.1

23
Q

If you’ve had a bleed on NSAID how likely are you to have a second bleed?

A

Patients who developed a bleeding ulcer while taking NSAIDs or low-dose aspirin are at least 10 times more likely to have a subsequent ulcer bleed if they recommence NSAIDs or aspirin.1

24
Q

If prescribing an NSAID in a patient with increased GI bleeding risk ?

A

COX 2 inhibitor (Eg celcoxib 100mg bd)

+

PPI (20 or 40mg)

25
If a patient with biliary colic demonstrates gall bladder polyps on ultrasound?
If there were gall bladder polyps found on the ultrasound, it would be recommended that Omar have ultrasonography performed every six months for two years to ensure that there is no growth beyond 10 mm ( A polyp greater th 20mm increases risk of malignancy and requires cholecystectomy at over 10mm If patient has IBD or PSC - then any polyps are risky and need to be removed
26
Difference between adenomatous and non adenomatous gall bladder plyps
non adenomatous are usually less than 10 mm and represent cholesterol deposits and can be watched and managed with elective cholecystect if sypmtpms persist ADenomatous are rare - over 20mm increases risk of malignancy but if over 10mm needs cholecystectiomy
27
A non jaundiced patient presents with ?Cholecystitis and ultrasound demonstrates biliary obstruction (Dilated ducts **over 6mm)**
Likely cholangitis and need IV abx as well as biliary decompression through and ERCP
28
What happens to a patient with cholangitis who is on Anticoagulants or has IHD
Increased bleeding risk and so does ERCP and temporary plastic stenting (sometimes omitting stone removal and sphincterotomy) REmoval of stent at two months - then stone removal and sphincterotomy
29
If the obstruction is above the common bile duct but below the intrahepatic ducts what is it called and how is it managed?
If the obstruction is above the common bile duct but below the intrahepatic ducts, the most likely cause is **Mirizzi syndrome.** This occurs when a large gallstone becomes impacted at the cystic/bile duct junction and occludes the common hepatic duct, leading to biliary obstruction. The differential diagnosis is a malignancy of the gall bladder or bile ducts. **Cross-sectional imaging with a CT scan or magnetic resonance imaging** is useful to exclude features of malignancy. Management of Mirizzi syndrome is usually complex. A **cholecystectomy c**an sometimes be performed to resolve the situation. However, there is often severe inflammation of the bile duct, or even fistula between the common bile duct and gall bladder. Other management approaches, including a **partial or subtotal cholecystectomy** with or without biliary procedures, are commonly undertaken. **Decompression of the infected biliary tree is mandatory, and this is usually achieved through biliary stenting.** In rare cases, **bile duct reconstruction using biliary-enteric anastomosis is required.**
30
How would you manage biliary colic
In the meantime, management comprises analgesia and avoidance of fatty foods. It is worth reminding patients that fatty foods include ‘healthy’ fats such as avocado, nuts and olive oil. Analgesia for biliary colic includes paracetamol, nonsteroidal anti-inflammatory drugs and, in some cases, opiates if other choices have not proven effective. Some patients report symptomatic relief with antispasmodics.
31
How should refractory biliary colic be managed
1. Referral for expedited cholecystecomy 2. Analgesia - PCM, NSAIDS, Antispasmodics 3. Safety netting - emergency dept if uncontrolled pain,vomiting, dehydration or jaundice 4. Avoidance of fatty foods (including good fatS)
32
Managmenet of gallbladder disease during preg
1. , Lap chole is ok in any trimester 2. Open chole only ok in 2nd trimester. 3. Radiation may be an issue with ERCP and may need intraop choledocoscopy instead 4. Discuss with obs and gastro re: risk/benefit. sometimes wait till after preg if only mild disease pregnancy in any term is not an absolute contraindication for cholecystectomy.2 There should be a conversation with the managing obstetric team and the surgical team about the patient, and risks and benefits need to be weighed. For instance, a mild, single attack of biliary colic might be managed conservatively until after birth, whereas acute cholecystitis or choledocholithiasis might be managed with surgery. The use of intra-operative radiation should be minimised; if it is required, there should be shielding of the fetus in place. This sometimes means that an intraoperative choledochoscopy will be used in preference to ERCP to clear common bile duct stones if present.
33
Post operative advice after lap chole
time off work - one week off sedentary work, no heavy lifting for six weeks wound management - dressings can be removed after one week, can swim once scab replaced by dry scar (usually at 3 weeks) - monitor signs of infection driving - dont drive if under influence of opiate meds - usually ok to drive after a few days diet - monitor for diarrhoea pain control. - pcm/nsaids may need short course of opiate nanalgesic. iF persists needs investigation - bile leak? postcholecystectomy syndrome -eg sphincter of oddi dysfunction -needs gastro referral