Urology Flashcards
(153 cards)
Most common type of bladder cancer?
Urothelial (Transition cell) carcinoma
How does bladder ca present?
- PAINLESS HAEMATURIA 2. Irratitive voiding symptoms - dyuria, frequency, urgency
In which type of bladder cancer are voiding symptoms most common?
In bladder carcinoma in situ Can result from - functional decrease in bladder volume, detrusor overactivity, invasion of the trigone, obstruction of the bladder neck or urethra
Investigations in bladder cancer?
- Gross examination of urine with chemical dipstick
- Urine microscopy
- Cystoscopy - Diagnostic and treatment - allows for diagnosis, assessment of muscle invasion, and treatment for non muscle invasive lesions.
- Urine cytology - used in conjunction with cystoscopy to assess for upper urinary tract lesions and assess for CIS.
- CT - assess for local invasion, metastases and assess renal pelvis and ureters
Irritative voiding symptoms vs obstructive voiding symptoms in bladder ca?
Irritative - frequency, urgency, nocturia, dysuria, urge incontinence
Suggests CIS
Obstructive - straining, intermittent stream, decreased force of stream, feeling of incomplete voiding
Suggests tumor located at bladder neck or prostatic urethra
On occasion gross heamaturia can result in clot retention.
Definition of erectile dysfunction?
Persistent inability to achieve or maintain an erection sufficient for sexual interctourse
What percentage of cases of Erectile dysfunction have an organic cause?
80% - neurovascular, DM, or Medications
20% - psychogenic
What is erectile dysfunction a risk marker/major predictor for?
CV disease
How do you know if a man is fit to resume sexual intercourse?
Able to exercise equivalent to walking up 20 stairs in 15 seconds.
What history questions would you ask a patient with erectile dysfunciton?
Confirm impotence - ?premature ejaculation or Loss of libido (male hypoactive sexual desire disorder)
Date of last successful sex?
Frequency of sex?
Relationship issues?
Able to attain morning erections or during masturbation?
Cardiovascular risk factors?
CV disease - obesity, diabetes, PAD, HTN
OSA
Endocrine issues/symptoms?
Drug and Alcohol use?
Medications?
Depressive symptoms?
Recent pelvic surgery or radiation?
Prostate issuse? cancer?
Neurological - Alzheimers? MS? Parkinsons?
Anaemia?
Liver disease or kidney?
NOTE: Erectile dysfunction may be the first symptom of coronary artery disease
Causes of Erectile Dysfunction?
- Organic - mainly vascular
_ vascular,
neurogenic
endocrine
traumatic
anatomical
drug induced
- Psychogenic (depression/anxiety/stress)
- Mixed (above 2)
What medications can cause erectile dysfunction?
1.
Psych drugs - Antipsychotics, anxiolytics (benzos), Antidepressants - SSRI, TCA, MAOinhibitors
- Neuro drugs (parkinsons/epilepsy) - levodopa, phenytoin and carbamazepine
- Anti hypertensive meds - ACEI, BB, CCB - esp verapamil, Diuretics - thiazide and spironolactone
- Statins HMG CoA reductase inhibitors
- Antiarrhythmics - Amiodarone and digoxin
- Hormonal - GnRH agonists, steroids, 5 alpha reductase inhibitors
- H2 receptor antagonists - ranitidine, cimetidine
What examination is important in erectile dysfunction?
- Genitourinary.
- Cardiovascular
- mental state
- Neurological
- Endocrine - thyroid
- PR - prostate
- Testis - size/atrophy
- Penis examine for peyronie’s plaques
Investigations in Erectile dysfunction?
FBE - anaemia - lethargy induced?
CV risk -fasting glucose and lipids
LFT and UEC - (GGT increases with ETOH, also LFT/UEC important when commencement on PDE5 inhibitors)
B12 - neuropathy
+/- PSA (after counselling, as treatment for prostate Cancer can cause ED)
Hormones - Early morning testosterone (BEFORE 11 AM), TSH, Prolactin, LH
How is testosterone involved in attaining an erection?
- Libido
- Cavernous nerve structure and function
- NOS synthesis
- Corporal smooth muscle function
What’s your managment approach for a patient with Erectile dysfunction
- Explain its common - often organic and can be exacerbated by psychological factors such as relationship disharmony or performance anxiety.
- Explain that it is a risk factor for cardiovascular disease. Encourage balanced diet, half an hour of exercise on most days (150-300mins moderate intesenity activity per week) Dilligent monitoring and treatment of cardiovascular risk factors such as lipid, glycaemic and blood pressure control.
If appropriate encourage weight loss to achieve a health body mass index and waist circumference below 94cm (90cm in asian men) (this will also improve OSA)
3.Measure the risk of sexual activity on cardiovasdular health.
Can the climb 20 steps in 15 seconds. Or 1.6 kilometres in 20 minutes (on flat)
If low risk - can have sex, intermediate risk - further Ix, high risk - cardiologist review before sex
- Stop smoking, reduce alcohol intake to no greater than 2 standard drinks a day
- Referall to psychologist if there are psychogenic causes or distress from ED.
- Assess underlying causes and manage them
- If the patient is FIT for sex - then prescribe PDE5 inhibitors
- sildenafil, vardenafil and tadalafil - If PDE5 inhibitors are unsuccessful - intracorporeal injection followed by vacuum pumps, low intensity extra corporeal shockwave lithotripsy and implantable devices.
Note testosterone therapy may inhibit GnRH - hence testosterone is not usually a treatment for impotence.
What are the absolute contraindications to PDE5 inhibitors?
- Nitrate use
- Alpha blockers (eg prazosin, tamsulosin)
- Recent MI
- Recent Angina
- Recent CVA
What are the relative contraindications to PDE5 inhibitors?
Ventricular outflow obstruction (eg Aortic stenosis)
Priapism
Retinitis pigmentosa
Long QT and antiarrhythmic use for vardenafil
What can delay clearance of PDE5 inhibitors from the body?
older men
kidney or liver impairment
taking drugs that inhibit CYTp450 3A4 (eg erythromycin and fluoxetine)
What would you tell a patient or colleague about PDE5 inhibitors?
- they are first line treatment
- Doesn’t Initiate an erection (just optimises patients own capacity) - (hence not as effective in autonomic neuropathy or pelvic vascular disease)
- Don’t have it with fatty food or alcohol
- Take on an empty stomach (Tadalafil is unaffected by food)
- Take before sexual activity (all commence working after 15 minutes to an hour of ingestion)
- SIldenafil half life - 4 hours
- Vardenafil half life - 8 hours
- Tadalafil half life - 36 hours
Advise about common side effects - nasal congestion, headache ,facial flushing, dizziness, dyspepsia (disturbed colour vision with sildenafil and vardenafil - back pain fro tatadalafil)
Patient you’ve started on PDE5 inhibitor states that it is ineffective after second dose. What would your approach be?
Explain to the patient that usually 7-8 doses at maximum dosage are required before can prove that it is ineffective. Common for the first few doses to be ineffective. (ADR reduce over time - if intolerable then cease)
What are the common side effects of PDE5 inhibitor medications?
common side effects - nasal congestion, headache ,facial flushing, dizziness, dyspepsia (disturbed colour vision with sildenafil and vardenafil - back pain fro tatadalafil)
What treatment is secondline for erectile dysfunction?
Intracavernosal vasodilator injections (should be supervised by an experienced practitioner)
A patient attends wanting to know about ‘self administered injections” for Erectile dysfunction. What do you tell them?
Alprostadil intracavernosal injections (prostaglandin E1)
self administered after supervised teaching (use a penile model if available)
start with lower dose 2.5 - 5mcg.
Spontaneous erection in 5 to 20 minutes
If prolonged erection > 2 hours - take 120mg pseudoephedrine orally and have a hot shower - repeat at 4 hours if necessary (as long as not hypertensive).



