Urology Flashcards

(153 cards)

1
Q

Most common type of bladder cancer?

A

Urothelial (Transition cell) carcinoma

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2
Q

How does bladder ca present?

A
  1. PAINLESS HAEMATURIA 2. Irratitive voiding symptoms - dyuria, frequency, urgency
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3
Q

In which type of bladder cancer are voiding symptoms most common?

A

In bladder carcinoma in situ Can result from - functional decrease in bladder volume, detrusor overactivity, invasion of the trigone, obstruction of the bladder neck or urethra

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4
Q

Investigations in bladder cancer?

A
  1. Gross examination of urine with chemical dipstick
  2. Urine microscopy
  3. Cystoscopy - Diagnostic and treatment - allows for diagnosis, assessment of muscle invasion, and treatment for non muscle invasive lesions.
  4. Urine cytology - used in conjunction with cystoscopy to assess for upper urinary tract lesions and assess for CIS.
  5. CT - assess for local invasion, metastases and assess renal pelvis and ureters
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5
Q

Irritative voiding symptoms vs obstructive voiding symptoms in bladder ca?

A

Irritative - frequency, urgency, nocturia, dysuria, urge incontinence

Suggests CIS

Obstructive - straining, intermittent stream, decreased force of stream, feeling of incomplete voiding

Suggests tumor located at bladder neck or prostatic urethra

On occasion gross heamaturia can result in clot retention.

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6
Q

Definition of erectile dysfunction?

A

Persistent inability to achieve or maintain an erection sufficient for sexual interctourse

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7
Q

What percentage of cases of Erectile dysfunction have an organic cause?

A

80% - neurovascular, DM, or Medications

20% - psychogenic

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8
Q

What is erectile dysfunction a risk marker/major predictor for?

A

CV disease

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9
Q

How do you know if a man is fit to resume sexual intercourse?

A

Able to exercise equivalent to walking up 20 stairs in 15 seconds.

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10
Q

What history questions would you ask a patient with erectile dysfunciton?

A

Confirm impotence - ?premature ejaculation or Loss of libido (male hypoactive sexual desire disorder)

Date of last successful sex?

Frequency of sex?

Relationship issues?

Able to attain morning erections or during masturbation?

Cardiovascular risk factors?

CV disease - obesity, diabetes, PAD, HTN

OSA

Endocrine issues/symptoms?

Drug and Alcohol use?

Medications?

Depressive symptoms?

Recent pelvic surgery or radiation?

Prostate issuse? cancer?

Neurological - Alzheimers? MS? Parkinsons?

Anaemia?
Liver disease or kidney?

NOTE: Erectile dysfunction may be the first symptom of coronary artery disease

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11
Q

Causes of Erectile Dysfunction?

A
  1. Organic - mainly vascular

_ vascular,

neurogenic

endocrine

traumatic

anatomical

drug induced

  1. Psychogenic (depression/anxiety/stress)
  2. Mixed (above 2)
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12
Q

What medications can cause erectile dysfunction?

A

1.

Psych drugs - Antipsychotics, anxiolytics (benzos), Antidepressants - SSRI, TCA, MAOinhibitors

  1. Neuro drugs (parkinsons/epilepsy) - levodopa, phenytoin and carbamazepine
  2. Anti hypertensive meds - ACEI, BB, CCB - esp verapamil, Diuretics - thiazide and spironolactone
  3. Statins HMG CoA reductase inhibitors
  4. Antiarrhythmics - Amiodarone and digoxin
  5. Hormonal - GnRH agonists, steroids, 5 alpha reductase inhibitors
  6. H2 receptor antagonists - ranitidine, cimetidine
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13
Q

What examination is important in erectile dysfunction?

A
  1. Genitourinary.
  2. Cardiovascular
  3. mental state
  4. Neurological
  5. Endocrine - thyroid
  6. PR - prostate
  7. Testis - size/atrophy
  8. Penis examine for peyronie’s plaques
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14
Q

Investigations in Erectile dysfunction?

A

FBE - anaemia - lethargy induced?

CV risk -fasting glucose and lipids

LFT and UEC - (GGT increases with ETOH, also LFT/UEC important when commencement on PDE5 inhibitors)

B12 - neuropathy

+/- PSA (after counselling, as treatment for prostate Cancer can cause ED)

Hormones - Early morning testosterone (BEFORE 11 AM), TSH, Prolactin, LH

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15
Q

How is testosterone involved in attaining an erection?

A
  1. Libido
  2. Cavernous nerve structure and function
  3. NOS synthesis
  4. Corporal smooth muscle function
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16
Q

What’s your managment approach for a patient with Erectile dysfunction

A
  1. Explain its common - often organic and can be exacerbated by psychological factors such as relationship disharmony or performance anxiety.
  2. Explain that it is a risk factor for cardiovascular disease. Encourage balanced diet, half an hour of exercise on most days (150-300mins moderate intesenity activity per week) Dilligent monitoring and treatment of cardiovascular risk factors such as lipid, glycaemic and blood pressure control.

If appropriate encourage weight loss to achieve a health body mass index and waist circumference below 94cm (90cm in asian men) (this will also improve OSA)

3.Measure the risk of sexual activity on cardiovasdular health.

Can the climb 20 steps in 15 seconds. Or 1.6 kilometres in 20 minutes (on flat)

If low risk - can have sex, intermediate risk - further Ix, high risk - cardiologist review before sex

  1. Stop smoking, reduce alcohol intake to no greater than 2 standard drinks a day
  2. Referall to psychologist if there are psychogenic causes or distress from ED.
  3. Assess underlying causes and manage them
  4. If the patient is FIT for sex - then prescribe PDE5 inhibitors
    - sildenafil, vardenafil and tadalafil
  5. If PDE5 inhibitors are unsuccessful - intracorporeal injection followed by vacuum pumps, low intensity extra corporeal shockwave lithotripsy and implantable devices.

Note testosterone therapy may inhibit GnRH - hence testosterone is not usually a treatment for impotence.

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17
Q

What are the absolute contraindications to PDE5 inhibitors?

A
  1. Nitrate use
  2. Alpha blockers (eg prazosin, tamsulosin)
  3. Recent MI
  4. Recent Angina
  5. Recent CVA
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18
Q

What are the relative contraindications to PDE5 inhibitors?

A

Ventricular outflow obstruction (eg Aortic stenosis)

Priapism

Retinitis pigmentosa

Long QT and antiarrhythmic use for vardenafil

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19
Q

What can delay clearance of PDE5 inhibitors from the body?

A

older men

kidney or liver impairment

taking drugs that inhibit CYTp450 3A4 (eg erythromycin and fluoxetine)

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20
Q

What would you tell a patient or colleague about PDE5 inhibitors?

A
  • they are first line treatment
  • Doesn’t Initiate an erection (just optimises patients own capacity) - (hence not as effective in autonomic neuropathy or pelvic vascular disease)
  • Don’t have it with fatty food or alcohol
  • Take on an empty stomach (Tadalafil is unaffected by food)
  • Take before sexual activity (all commence working after 15 minutes to an hour of ingestion)
  • SIldenafil half life - 4 hours
  • Vardenafil half life - 8 hours
  • Tadalafil half life - 36 hours

Advise about common side effects - nasal congestion, headache ,facial flushing, dizziness, dyspepsia (disturbed colour vision with sildenafil and vardenafil - back pain fro tatadalafil)

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21
Q

Patient you’ve started on PDE5 inhibitor states that it is ineffective after second dose. What would your approach be?

A

Explain to the patient that usually 7-8 doses at maximum dosage are required before can prove that it is ineffective. Common for the first few doses to be ineffective. (ADR reduce over time - if intolerable then cease)

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22
Q

What are the common side effects of PDE5 inhibitor medications?

A

common side effects - nasal congestion, headache ,facial flushing, dizziness, dyspepsia (disturbed colour vision with sildenafil and vardenafil - back pain fro tatadalafil)

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23
Q

What treatment is secondline for erectile dysfunction?

A

Intracavernosal vasodilator injections (should be supervised by an experienced practitioner)

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24
Q

A patient attends wanting to know about ‘self administered injections” for Erectile dysfunction. What do you tell them?

A

Alprostadil intracavernosal injections (prostaglandin E1)

self administered after supervised teaching (use a penile model if available)

start with lower dose 2.5 - 5mcg.

Spontaneous erection in 5 to 20 minutes

If prolonged erection > 2 hours - take 120mg pseudoephedrine orally and have a hot shower - repeat at 4 hours if necessary (as long as not hypertensive).

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25
Do vacuum devices have a place in managment of erectile dysfunction?
Where pharmacological therapies have failed or are inappropriate VEDS are often poorly tolerated long term due to sideeffects: pain inability to ejaculate bruising paraesthesia
26
Surgical options for erectile dysfunction?
1. Malleable penile prosthesis 2. Inflatable penile prosthesis
27
What is the relationship between Diabetes and Erectile dysfunction?
After Dx of DM - 50% patients will have erectile issues in 10 years Overall prevalence of ED in DM population is 35-70% Men with DM have 2x more ED than men without DM
28
What are causes of haematuria?
29
How would you manage persistent microscopic haematuria?
30
How would you manage Macroscopic haematuria?
31
In what cases can haematuria be misleading?
If = collected from a woman during menses shortly after vigorous exercise shortly after acute trauma -Repeat urinalysis in 6 weeks with microscopy. Mimics of haematuria: Beeturia Pigmenturia Menstruation Drugs - rifampicin, phenytoin, nitrofurantoin
32
How would you manage a patient with suspected urolithiasis and a concurrent UTI
Potentially life threatening emergency - can lead to gram negative sepsis. Immediate transfer to Emergency department for urgent urological review and management.
33
In what instances apart from concurrent UTI would you send a patient with suspected urolithiasis to the emergency department?
RF's: single kidney anuria bilateral obstruction severe premorbid renal failure
34
What is the imaging modality of choice for suspected urolithiasis?
CT KUB
35
What size stones can be managed conservatively
Usually stones less than 7 mm
36
What is the best analgesia in renal colic?
NSAIDS Regular Tamsulosin can help passage of stone
37
If a patient has a large stone or has failed conservative management what would you do?
Outpatient urology referral
38
What symptoms might a well patient with a ureteric stent present with?
Dysuria, haematuria, flank pain, urgency. Normal for patients with ureteric stents. Dipstick not helpful in patients with stents
39
How can stent symptoms be improved?
Tamsulosin and/or anticholinergic meds
40
Lifestyle management for patients with urolithiasis
Keep well hydrated Diet low in salt, oxalate and protein
41
How do we define persistent microscopic haematuria
2 out of 3 dipsticks positive for blood
42
If haematuria has been found with a UTI what should be done?
Repeat urine MCS in 6 weeks to confirm haematuria has settled
43
In what cases can a urine dipstick produce a false positive for blood?
Myoglobin - rhabdomyolisis urinary haemolysis - intravascular haemolysis semen in urine - can falsely test as blood on dipstick IN these groups - Urine microscopy would not show RBC
44
Causes of LUTS
Also OSA, Diabetes insipidius, CVA,Dementia Drugs - lithium, diuretics, anticholinergics,
45
Child presents with a red and tender inguinal swelling with lump that is difficult to reduce. What is the diagnosis? How is it managed?
Obstructed indirect inguinal hernia Attempt manual reduction. If irreducible transfer urgently for surgical reduction.
46
What are the symptoms and managment of a non obstructed indirect inguinal hernia
Lump appears when baby is crying But reduces. examination - 1) thick spermatic cord 2) may feel a lump on abdominal palpation Management: Always needs ultrasound -of BILATERAL INGUINAL REGIONS. **6-2 rule** Less than 6 weeks old - surgery within 2 days 6 weeks to 6 months - surgery within 2 weeks Greater than 6 months - surgery within 2 months
47
When should an umbilical hernia be operated upon?
surgery at 3 years
48
How would you identify a hydrocele in an infant? Management?
Painless testicular lump often bilateral nil impulse with cry can vary in size from day to day May resolve : 1. Do an ultrasound - to see if primary or secondary 2. Surgery/surgical assessment at **one and half years**
49
50
If orchidopexy is performed for undescended testicle within 12 months - what is prognosis? What happens if you wait?
Excellent prognosis in first year if orchidopexy performed. If testes are left at 37 degrees - by end of year one the germ cells become damaged and fertility is affected. Cancer risk increases
51
If orchidopexy occurs before puberty does it eliminate cancer risk?
No. Reduces but doesnt eliminate risk. Should happen in first year of life if possible.
52
Which hormones regulate descent of the testis in neonate
Testosteron Insuline Like Peptide 3 Released from leydig cells
53
What percentage of children have no testis in scrotum at birth?
2.5% 90 % will felt in groin 10% not felt at all
54
If at birth - both testes are found in groin (not scrotum) what is your management?
Review in 3 months IF still in groin (50%) - refer to surgeon for orchidopexy If now in scrotum (50%) - patient needs yearly review as it can become and aquired UDT
55
If no testes is felt at all (either in groin or scrotum) at birth what is your management?
1. Look for hypoplastic scrotum - sign that testes have never been in scrotum 2. Consider female with congenital adrenal hyperplasia (virilisation) 3. Perform karyotyping 4. UEC - as they can have low Na+ secondary to hypoaldosteronism 4. Ultrasound of scrotum/abdomen - to assess for internal organs - testes or for ovaries/uterus
56
What size should a normal testes be?
Size of glans penis
57
If one testis is atrophic/hard/vanished and the other one is larger than glans penis (hypertrophic) - management?
Ultrasound needed to exclude cancer - seminoma REFER To surgeon
58
If one testis is palpable and normal size (same as glans penis) but the other is impalpable - managment?
REfer to surgeon for laporoscopic exploration (could be absent, retractile or Acquired UDT)
59
When do you perform ultrasound in undescended testicles?
IF - no testes at all - to check for uterus/ovaries If one testis is large or irregular - to check for cancer/seminoma
60
What is the temp of testes in scrotum compared to in body
33 degrees in scrotum 37 in body
61
What happens if testes have not descended first year
cancer risk (Seminoma) as well as risk of subfertility
62
Why are some testes retractile? When do they present?
Processus vaginalis is not obliterated at birth 50% will go on to stay in testes (obliterates) 50% will get worse - more retractile and can cause acquired UDT Usually presents between 2-6 years of age REFER TO SURGEON
63
64
What happens if a surgeon elects not to operate on a retractile testis? Instead pulls manually
If it doesnt stay in scrotum - needs surgery If it does stay - Then annual review of retractile testis to ensure it doesnt become an acquired undescended testicle (as soon as this occurs - needs orchidopexy) Whilst it may not pose a cancer risk if descended before 12 months - it still can affect fertility. Testosterone at puberty will cause testes to descend
65
What is a retractile testes
These are descended testicles that have been pulled into a suprascrotal position by the cremasteric reflex. Can be pulled down - need to overcome reflex for one minute
66
Is imaging needed for a non palpable testes?
NO. needs exploratory surgery
67
Cryptorchidism vs undescended testicle?
Cryptorchid testes can be absent or undescended. (hidden testes) Undescended - has formed but has not descended into scrotum
68
A patient presents with thickened, phimotic foreskin, white lesions to glans with bleeding, ulceration, and difficulty voiding Dx? Mx?
Balanitis xerotica obliterans Icing sugar appearance to glans Can get meatal stenosis Bleeding/ulceration/phimosis/ painful erections Mx. Mild cortiocsteroid ointment or cream first 2. will need circumcision if not settling
69
What are the causes of balnoposthitis/balanitis in kids? Initial treatment?
1. Chemical irritation - urine trapping, soiled nappies, soap residue. 2. Physical trauma - forcible retraction. 3. Candida nappy rash in infants Mx: Soak in warm salt water - settles discomfort Barrier or 1% hydrocortisone cream Antifungal cream if candida is suspected Dont retract foreskin during acute inflammation as this can lead to paraphimosis If fever, dysuria present - check Urine MSU Group A strep can cause a genital rash that is weeping and raw - fluclox 25mg/kg six hourly for seven days or cephalexin 25mg/kg six hourly for seven days
70
What is balanoposthitis?
Inflammation of glans penis and prepuce
71
Causes of balanoposthitis in adults
Commonly due to contact irritant dermatitis from urine trapping under foreskin being converted to NH3 or to fragrances, rubber in condoms Systemic causes - scabies, lichen planus, psoriasis,syphilis, fixed drug eruption (look for evidence of other features) Mx - Swab to distinguish bacterial from fungal If fungal: Hydrozole cream 1% BD for two weeks IN kids - if GAS - treat with fluclox/cephalexin 25mg/kg 6hrly for seven days if candida (clotrimazole) - suggests contact irritant dermatitis Reduce inflammation with: Methylprednisolone aceponate 0.1 % once daily for seven days
72
Medical indications for circumcision? Side effects of surgery?
Recurrent balanoposthitis Balanitis xerotica obliterans Phimosis paraphimosis Recurrent UTI with upper UT anomaly Side effects - bleeding, pain, infection Takes 10 days for discomfort to settle
73
What are some problems post circumcision and how to deal with them?
Inflammation and crusting of the glans penis for a few days after circ is common. - vaseline liberally to the nappy or panty liner helps Infection - treat Bleeding - apply compressive pressure to the area and seek surgical advice
74
Circumcision benefits?
Some benefit in preventing UTIS in boys, esp with urinary tract abnormality reduces penile cancer - poss by preventing phimosis HIV? - not as effective as safe sex practices in low risk populations May have some benefit in reducing Cervical ca in high risk populations but not as good as the HPV vaccination NO effect on prostate ca
75
When should foreskin be retracted for cleaning in infants and boys?
Only once natural separation of foreskin from glans penis has occurred
76
What are the rules for retracting normal foreskin
1. Should only be retracted by the owner (or a health professional) 2. should NOT be retracted forcibly 3. Once spontaneous retraction has occurred, encourage daily retraction and gentle cleansing in bath or shower.
77
Instructions to patients about cleaning foreskin
during shower or bath slide foreskin back towards your body Wash the end of the penis and foreskin with soap and water and then rinse off THen dry the area and replace foreskin If foreskin gets irritated and smelly - slide foreskin back sufficiently to allow free urination
78
Epidemiology/causes of phimosis?
At birth non retractile prepuce - NOT phimosis 40% become retractile at 1 year 90% by 4 years 99% by 15 years Phimosis is prepuce becoming non retractile because of: 1. Infections 2. BXO 3. Forceful retraction and scarring
79
When would you diagnose phimosis? Treatment ?
difficult to retract foreskin may have scarring was retractile - now is not Balooning of foreskin with micturition OR non retractile by puberty - possibly had it forcibly retracted as child and now is phimosed Rx - Betamethasone 0.05% 4 x daily for four weeks iF fails - surgery
80
Cx of paraphimosis?
Gangrene, ischaemia and amputation
81
Rx of paraphimosis
Urgent manual reduction - with a penile block (dont use adrenaline) or generous application of 2% lignocaine gel 5 - 10 minutes before hand If fails needs urgent referral for surgery
82
Definition and classificaiton of premature ejaculation?
Persistent, recurrent ejaculation before, on, or shortly after penetration (majority within one minute of penetration/minority 1-2 minutes after) Primary: lifelong Secondary: situational factors/secondary to erectile dyfunction
83
How would you treat premature ejaculation?
IN secondary - treat the underlying cause In primary - reduce the sensitivity of the glans penis and certain SSRIs delay ejaculation 1. Topical cream - Lignocaine + prilocaine 2.5 % + 2.5% 10 to 20 minutes before sex 2. Sertaline 50mg 3 hours before sex
84
What are the causes of priapism?
Low flow (ischaemic) Decreased venous outflow - most common -Hypercoagulable state - sickle cell, thalassemia Neurological disease - Spinal cord stenosis Metastatic disease - Prostatic Cancer, bladder cancer Medications relaxing smooth muscle - eg prostaglandins, PDE5 inhibitors, hydralazine NB MOST COMMON CAUSE IS intracavernosal alprostadil HIGH flow = increased arterial inflow (non-ischaemic) Penile/Perineal trauma -rupture of cavernous artery --\> fistulat formation between cavernosal artery and corpus cavernosum
85
What is priapism?
Persistent involuntary erection,unrelated to sexual stimulation, unrelieved by ejaculation
86
How do you differentiate low flow (ischaemic) and high flow (non ischaemic) priapism
_Low flow_ - usu painful - RIgid erection - dark blood on coporeal aspiration _High flow_ Not painful episodic trauma evidence
87
What is the acute management of priapism in someone taking intracavernosal injections?
If erection lasts longer than 2 hours 1. hot shower. 2. Pseudoephedrin 120 mg orally immediate release (also can try a cold pack if by 4 hrs no improvement one more 120mg tablet and call doctor if by 6hrs no improvement - attend ED for aspiration and drainage of copora cavernosa Complications - erectile dysfunction/disfigurement
88
When would a patient with prostatis need more than basic treatment?
Fever \> 38 degrees celsius systemic features - chills/sweats sepsis/septic shock Needs IV antibiotics in hospital
89
Which organisms commonly cause prostatitis?
Ecoli Klebsiella proteus Also Chlamydia and gonorrhea
90
Ix in prostatis?
Urine MCS if concerned about prostatic abcess - then u/s
91
What is chronic prostatitis? HOw is it confirmed? Treatment
Recurrent UTI with culture of a recognised Uropathogen from urine or prostatic fluid Confirmed with the two glass test Urine culture and leukocyte counts pre and post prostatic massage FOUR WEEKS OF ANTIBIOTICS - eg cipro 500mg bd or trimethoprim 300mg daily (depending on susceptibilities)
92
What are the most common kinds of renal carcinoma?
1. RCC (renal cell carcinoma 2. Transitonal cell 3. Wilms tumour in kids (nephroblastoma) Can be primary or secondary cancers - and its primary that are clinically significant (Dont need to worry about secondary)
93
What kind or renal cysts need follow up with CT?
Complex cyst or solid mass Simple cysts dont need further follow up
94
For complex renal cysts/cystic masses found on imaging what classification system exists
Bosniak categories
95
What are risk factors for renal stones?
More men than women Age Indigenous status Family history History of previous stone (30-50% of ppl with a stone will have another in 5 years)
96
Symptoms and signs of urolithiasis?
Renal colic +/- haematuria Also can present as vague abdo pain/flank pain/urgency/ frequency/stranguria (small painful voids)/penile or testicular pain/difficulty voiding
97
What initial investigations would you organise if you suspect a renal stone?
Urine Dipstick Urine MCS UEC - check GFR CT KUB (simultaneously do a KUB Xray (for follow up surveillance)
98
What is the initial management for a ureteric stone?
1. Analgesia with paracetamol, NSAID and codeine If no red flags: 2. Tamsulosin 400mcg daily to help passage of stones 3. Increase FLuid intake 4. If conservatively managed - advise patient to strain urine to avoid unnecessary imaging later 5. Repeat Xray KUB in 4 weeks if stone not passed 6. review in 4-6 weeks
99
When can ureteric stones be managed as an outpatient?
- If no fever - responds to analgesia - has two kidneys/ no retention - Small stone on CT \< 5mm and distal
100
101
What is the stone work up?
Serum Calcium uric acid PTH stone analysis Urine M/C/S 24 hour urine for calcium, oxalate, citrate, uric acid if patient is keen on going on stone prophylaxis (eg allopurinol, thiazide diuretic, potassium citrate)
102
103
What are the most common renal stones?
Calcium oxalate (80%)
104
What dietary recommendations are there for calcium oxalate stone prevention?
1. Increasing fluid intake throughout the day (to maintain 2L of urine/day) 2. Increase dietary potassium and phytate. 3. Decrease intake of oxalate, animal protein, sodium and supplemental calcium 4. Referal to a dietician
105
If theres evidence of continued new renal stone formation what drug therapies can be considered?
Thiazide diuretics - to reduce calcium excretion allopurinol - to reduce hyperuricosuria citrate - for hypocitraturia
106
How would you conservatively manage a ureteric stone (less than 7mm)?
1. Oral Paracetamol 1g qid prn 2. Indomethacin 50mg orally, three times daily 3. Tamsulosin 400micrograms daily for ureteric relaxation with or without oxycodone 5mg qid prn 4. PRESENT directly to the Emergency department if: - fever - becomes unwell - nausea and vomiting - unable to tolerate oral fluids - becomes non reponsive to pain medication 5. Strain her urine to catch the stone, - either use a seive or urinate into a white ice cream tub. Bring the stone in for stone analysis and to confimr passage. 6. Repeat imaging in 4 weeks 7. If stone not passed in 6 weeks - refer to urology
107
When should a patient with renal stones be referred to urology or emergency department?
1. Anatomical - single functioning kidney bilateral ureteric obstruction 2. Systemic - concurrent UTI or sepsis and obstruction, premorbid CKD stage 4 or 5, eGFR less than 30, Anuric renal failure, poorly controlled diabetes, 3. Pain - intractable pain and nausea
108
Indications for surgical intervention in renal stones?
1. Persistent pain 2. Stone unlikely to pass spontaneously 3. significant renal impairment 4. evidence of sepsis
109
What surgical options exist in ureteric colic?
Ureteroscopy and stenting Extracorporeal shockwave lithotripsy nephrostomy
110
What factors impact likelihood of stone passage?
1. Stone size (50% of 5mm stones will pass) 2. Stone location - stones in upper ureter or PUJ are less likely to pass than stones in the VUJ 3. Prior history of capacity to pass small stones
111
How would you identify and manage stent pain?
1. frequency, dysuria, haematuria and flank pain are classic 2. to diagnose a UTI here dipstick is not useful- can do a MSU culture, check inflammatory markers and look for fever, tachycardia 3. In the absence of infection - manage with NSAIDS - indomethacin 50mg TDS prn, tamsulosin 400micrograms daily and oxybutinin hydrochloride 2.5mg bd (Warn about anticholinergic side effects)
112
What history questions would you ask about male inferitlity?
Any medical conditions? Depression? mood disorders? Loss of libido - male hypoactive sexual desire disorder Erection? Ejaculation? When did secondary sexual characteristics first appear? how did they manifest? Frequency and timing of sex? PMHx - orchitis, STI, trauma, mumps PHx of undescended testis and surgery - cryptorchisdsim and orchidopexy MEDS - anabolic steroids, opioids, chemotherapy
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A patient who had cryptorchidism as a child and was operated on presents to see you about subferitility. How would you manage
Cryptorchid - need to have had orchidopexy by 6 months. Still increased testicular cancer risk c/f rest of population - so need regular testicular examination. Fertility may be affected depending on time to orchidopexy. this would be indicated bya) poorly developed secondary sexual characteristics b) small testis c) low testosterone despite high FSH and LH. Despite low test and sperm count - 30% will still be able to conceive. DO NOT give exogenous testosterone in these patients if they want to be fertile. As testosterone will inhibit GnRH and LH secretion - which will decrease fertility subsequently
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What are you looking for on testicular examination?
1. Examine standing first (varicocele fills) 2. Then examine lying down 3. Inspect testicles - size and shape 4. Inspect skin - sebaceous cyst? erythema? 5. If there's a lump - can you get above it/is it transilluminable/ is it separate to the testis? 6. Examine the testis 7. Examine the Epidydimis 8. Examine the spermatic cord 9. Examine hernial orifices 10. Examine cremasteric reflex (gentle stroke inner thight) raises ipsilateral testes. Absent in tortion. (most sensitive test in tortion but absent in boys less than 2.5 years) 11. Examine the prostate - associated prostatitis?
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What history questions would you ask about testicular pain?
Onset - acute or gradual (tortion - acute, no fever, severe pain) Fever? Nausea and vomiting? (tortion) Symptoms of dysuria? (Epidydimoorchitis) Trauma? Haematocele Any voiding difficulties HIstory of recent surgery or instrumentation Sexual history - any unprotected anal sex? REGARDLESS OF AGE - think of mumps - ARE THEY UP TO DATE WITH IMMUNISATIONS? Any flu like symptoms a week ago?
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DDx for testicular pain
1. tortion of testis 2. tortion of testicular appendage 3. Epidydimo orchitis/orchitis/mumps orchitis 4. strangulated hernia 5. hydrocele 6. varicocele. 7. Trauma haematocele 8. Testicular tumor (Rapid growing can in rare instance cause pain
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Signs and symptoms of testicular tortion?
Symptoms: Sudden onset no fever trauma sometimes nausea and vomiting Signs: Asymettric high riding testis negative phrens sign absent cremasteric reflex
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Signs and symptoms of epidydimitis
symptoms Insidious onset fever and rigors LUTS Sexual histoty symptoms SIgns Indurated testis Tender upper pole Positive Phrens sign Intact cremasteric
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Torsion of testicular appendage signs and symptoms
- gradual onset - moderate to severe pain - often localised to upper pole - often lacks systemic symptoms cremasteric reflex is often intact Signs: Localised tenderness to anterior testis BLUE DOT sign
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What is the epidemiology of epidydimo-orchitis
Young kids - one or both testes affected - MUMPS orchitis - ask about glands swollen in the neck Sexually active young adults - N.gonorrhea and Chlamydia Trachomatis are the most common under the 35 Older people - Ecoli, other coliforms and pseudomonas often with obstructive uropathy from BPH
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Which sexual practice predisposes to epidydimoorchitis
INsertive anal sex from exposure to coliforms in the rectum
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Investigations in epidydimoorchitis?
Urine M/C/S urine for gonorrhea and chlamydia Swab NAAT if discharge STI screen in young adults FBE CRP
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Management of Epidydimo orchitis
sexually aquired - treat with ceftriaxone 500mg IM and doxycylcine 100mg bd for 14 days (or azithromycin 1g stat) UTI related - treat same as for prostatatis trimethoprim 300mg daily for 14 days
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Whats the other name give to the testicular appendix
hydatid of morgani
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How would a testicular tortion be differentiated from tortion of appendix
blue dot sign/anterior localised pain Needs surgical exploration for definitivie differentiation
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Key differentiatiors for testicular tortion
Phrens and cremasteric negative Phrens is relief of pain when you lift up testicle - points to epidydimorchitis
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Management of haematocele acute and chronic?
Both need surgical exploration acute setting to exclude rupture of testicle in chronic to look for cancer
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What is the management of a testicular injury/trauma?
Blunt penetrating trauma/contusion o/e bruising/loss of testicular contour/swelling ULTRASOUND is investigation of choice Surgical exploration Haematocele is a collection of blood between two layers of tunica vaginalis - drain and repair the tunic vaginalis - may have lasting testicular damage and may need removal
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How would you manage a hydrocele in an adult?
ultrasound to exclude underlying pathology like tumour 1st line - conservative management - reassurance and scrotal support 2nd line - surgical aspiration +/- scelerosing agent With repeat aspirations there is a risk of bleeding/infection
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Epidemiology/symptoms of varicocele?
Common - 8-10% of men Left sided in 98% of cases May have dragging sensation. Bag of worms appearance Associated with infertility MAY PRESENT WITH ANY OF : Left sided dull pain worse with standing and relieved by recumbency Decreased fertility Atrophy of left testicle
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How would you manage a varicocele?
1. Generally doesnt need acute management 2. Tight underwear may settle dragging sensation. 3. **Surgery has three indications:** 1. Draggins sensation, symptomatic and doesnt settle with tight underwear 2. interferes with testicular growth esp in young patient 3. reduced fertility with reduced sperm quality - can check 1-2 years in pt with varicocele 4. If its associated with testicular atrophy
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What is the management pathway for Erectile dysfunction?
Cause: organic, psychosocial or combined * Patient and partner preferences * Benefits, risks and costs of treatment options Treatment summary 1st line • Alter modifiable risk factors and causes • Facilitate sexual health 2nd line • Oral agents (PDE5 inhibitors) * Counselling and education * Vacuum devices/rings 3rd line * Consider specialist referral * Intracavernous vasoactive drug injection 4th line * Specialist referral * Surgical treatment (penile implants)
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Key history features in Erectile dysfunction?
Lifestyle - esp CV risk factors, General health, Chronic CV or neurological disease, Medications (CV, neuro, psych, hormonal) ## Footnote Define the nature of the sexual dysfunction, ED onset, Spontaneous morning erections, Genital disease Penetration possible Maintenance of erection Depression Anxiety Relationship difficulties Sexual abuse
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Explain the first line management of Erectile dysfunction?
1st line treatment **Alter modifiable risk factors and causes** * Modify medication regime: Change current medications linked to ED (e.g. antidepressants, antihypertensives) when possible * Manage androgen deficiency: When diagnosed and a cause is established, androgen replacement therapy * Address psychosocial issues: Includes relationship difficulties, anxiety, lifestyle changes or stress **Facilitating sexual health** • Lifestyle changes: Smoking cessation, reduced alcohol, improved diet and exercise, weight loss, stress reduction, illicit drug cessation, compliance with diabetes and cardiovascular medications • Discuss sexual misinformation: Includes importance of suffi cient arousal and lubrication, and realistic expectations, such as normal age-related changes
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Explain the second line management of Erectile dysfunction?
Adapt dose as necessary, according to the response and sideeffects * Treatment is not considered a failure until full dose is trialled 7-8 times * Ensure patient knows that sexual stimulation is required for drug to work * Common side-effects: headaches, fl ushing, dyspepsia, nasal congestion, backache and myalgia * Contraindicated in patients who take long and short-acting nitrates, nitrate-containing medications, or recreational nitrates (amyl nitrate) * Exercise caution when considering PDE5 inhibitors for patients with: active coronary ischaemia, congestive heart failure and borderline low blood pressure, borderline low cardiac volume status, a complicated multi-drug antihypertensive program, and drug therapy that can prolong the half-life of PDE5 inhibitors **Counselling and education** • Offer brief counselling and education to address psychological issues linked with ED, such as relationship difficulties, sexual performance concerns, anxiety and depression • Consider concurrent patient/couple counselling with a psychologist, to address more complex issues, and/or to provide support during other treatment trials **Vacuum devices and rings** • Suitable for men who are not interested in, or have contraindications for pharmacologic therapies • Not suitable for men with severe ED • Typically suitable for patients in long-term relationships • Adverse effects include penile discomfort, numbness and delayed ejaculation
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What is third line treatment for erectile dysfunction?
3rd line treatment ## Footnote • Consider referral or specialist training Intracavernous vasoactive drug injection • Alprostadil (Caverject Impulse®): 10 and 20 mcg is the first choice for its high rate of effectiveness and low risk of priapism and cavernosal fibrosis. If erection is not adequate with alprostadil alone, it may be combined with other vasoactive drugs (bimix/trimix) to increase efficacy or reduce side-effects * Commence with minimum effective dose and titrate upwards if necessary * Initial trial dose should be administered under supervision of an experienced GP or specialist * Erection usually appears after 5 to 15 minutes and lasts according to dose injected. Aim for hard erection not to last longer than 60 minutes * Recommended maximum usage is 3 times a week, with at least 24 hours between uses * Contraindicated in men with history of hypersensitivity to drug or risk of priapism * Patient comfort and education are essential. Inform patient of side-effects (priapism, pain, fibrosis and bruising, particularly if on Aspirin or Warfarin). Provide a plan for urgent treatment of priapism if necessary
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Surgical treatments for erectile dysfunction?
4th line treatment ## Footnote * Refer to urologist (surgical treatments) * Penile prosthesis: A highly successful option for patients who prefer a permanent solution or have not had success with pharmacologic therapy. Surgery is irreversible and eliminates the normal function of the corpus cavernosa. Cost may be a limiting factor for some patients • Vascular surgery: Microvascular arterial bypass and venous ligation surgery can increase arterial in flow and decrease venous outflow but restoration of normal function is uncommon
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What tests should be ordered for a patient with haematospermia?
All patients should have _a urine microscopy, culture and sensitivity (MCS), urine cytology, and a full blood count and coagulation studies performed._ Other investigations may be considered in those patients with high risk (red flag) features such as: patient’s age (\>40 years) recurrent or persistent haematospermia prostate cancer risk factors (eg positive family history or African heritage) constitutional symptoms (eg weight loss, anorexia, bone pain). _If an STI is suspected,_ **urine NAAT for chlamydia and gonorrhoea** should be performed, ideally with a first-pass urine specimen. A prostate-specific antigen **(PSA)** assay should be performed in _men \>40 years of age or if DRE is abnormal or significant prostate cancer risk factors_ are present.
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