Gynae3 Flashcards

(46 cards)

1
Q

What are the clinical features of endometriosis?

A

Triad of 1) Dyspareunia 2) Dysmenorrhea (usually secondary) and 3) Menorrhagia

Often with subfertility

EXAMINATION FINDINGS

fixed retroverted uterus

Nodularity and tenderness in the pouch of Douglas

Enlarged tender uterus (main finding in adenomyosis)

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2
Q

How is the diagnosis of endometriosis made? Can treatment be started without it?

A

Gold standard is laporoscopy examination of pelvis/abdomen

for ectopic endometrial tissue

This can be supported by Pelvic ultrasound and clinical examination findings

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3
Q

Treatment of endometriosis

A
  1. First line - COCP and prn NSAIDs (Also wheat packs
  2. If contraindicated or does not improve symptom control - Progestogen only preparations are indicated

Subdermal implant, Depot injection, or POP -

Medroxyprogesterone 10mg bd for six months

or

Norethistrone 5mg bd for six months

3. GnRh agonists - eg Goserelin (dampen the hypothalamo-pituitary-ovarian axis)

4. Laparoscopy for investigation and treatment of pain - can excise focal ectopic tissue and adhesions which cause pain

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4
Q

At what age is oestrogen COCP and depo progesterone contraindicated?

A

Over 50

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5
Q

Which contraceptive methods are available to women in the perimenopause?

A

Non hormonal - if over 50 amenorrhea for one year - then cease.

If under 50 amenorrhea for two years - then cease.

Hormonal - POP, sub dermal implant, Levenorgestrel IUD

If use progestogen only and over 50 - then if FSH on two separate occasions separated by 6 weeks - is OVER 30 - then continue contraception for one year before no longer required

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6
Q

Features of primary dysmenorrhea?

A

Onset - adolescene - usually 6 to 12 months after menarche

Duration - First 2-3 days of period

No pain at other times of the menstrual cycle

No other kinds of pain

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7
Q

Features of secondary dysmenorrhea?

A

Mid to late 20s

Persists beyond first 2-3 days of period

Can have pain at other times during menstrual cycle

And other types of pain like dyspareunia

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8
Q

Do you need to perform a pelvic examination on a woman presenting with painful bleeding in the first few days of her menstrual cycle?

A

A) Young, never been sexually active - no examination needed

B) Until age of 29, sexually active women - need pelvic examination and appropriate screening - including chlamydia swab for NAAT.

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9
Q

When would you do investigations in dysmenorrhea?

A

If significant blood loss

or if symptoms suggestive of secondary cause - U/S, pregnancy test

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10
Q

Managment of primary dysmenorrhea

A

Ibuprofen 400mg tds for 48hours prior to commencement of the cycle and 2-3 days after +/- PPI

  1. OCP with 30mg ethinyloestradiol eg microgynon 30
  2. If NSAID and OCP not controlling pain - think of endometriosis and refer to specialist
  3. Regular exercise
  4. Stop smoking and reduce alcohol
  5. Heat pack/hot water bottle - local heat- for cramps
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11
Q

What is a uterine fibroid?

A

benign tumours of the smooth muscle of the myometrium

they can be - subserosal

intramural

subendometrial

intrauterine with a peduncle

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12
Q

How common are fibroids?

A

40-80% of women by age of 50 years

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13
Q

What are the symptoms of uterine fibroids?

A

Can be asymptomatic

Menorrhagia

metrorrhagia (Intermenstrual bleeding)

Dysmenorrhea

Infertility

Pressure symptoms - urinary frequency and hydronephrosis

Constipation

Pregnancy - First trimester bleeding, pain and miscarriage

2nd and 3rd trimester - placental abruption, pain, preterm delivery

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14
Q

Investigations in uterine fibroids?

A
  1. Pelvic Ultrasound
  2. C125 is used for monitoring treatment/post removal
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15
Q

Differential diagnosis for fibroids?

A

Uterine:

Pregnancy

Leimyosarcoma

Haematoma

Extra uterine:

Ovarian cyst

Ovarian tumour

Ectopic pregnancy

Pyosalpinx

Hydrosalpinx

Primary fallopian tube neoplasm

Pelvic abcess

Colorectal Carcinoma

Bladder carcinoma

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16
Q

Management of uterine fibroids?

A

Small, asymptomatic, young patient - monitor, no treatment

Large, young, asymptomatic - Monitor with ultrasound yearly (if patient does not want treatment)

Older age, rapidly enlarging, history of tamoxifen use - hysterectomy

Menorrhagia alone - tranexamic acid

Dysmenorrhea alone - Ibuprofen

GnRH agonist can reduce - but can cause menopause

If family completed - Hystectomy or uterine artery emboilisation - follow up with Ca 125

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17
Q

I

A
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18
Q

Risk factors for PCOS

A

Family history of PCOS

Family history of DM
ATSI or Asian women

Higher the BMI - the more likely

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19
Q

Key hormonal changes in PCOS

A
  1. Insulin resistance
  2. Hyperandrogenism

This is independent of/exacerbated by obesity

20
Q

How is Free Androgen Index calculated

A

Free Testosterone/SHBG and multiplied by a constant (usually 100)

21
Q

Any concerns about measuring FAI with OCP

A

OCP increases SHBG so needs three months off OCP before testing is accurate

22
Q

Investigations for PCOS

A

Total testosterone

SHBG (will be reduced in PCOS - indicates hyperinsulinaemia)

U/S pelvis and adrenals

LH, FSH

Exclusion of secondary causes

TSH

Prolactin

Serum BHCG

17 - hydroxprogesterone (elevated in CAH)

DHEA (markedly increased in patients with adrenal tumour)

23
Q

How does PCOS present?

A

Metabolic syndrome

hirsutism

GDM/DM

OSA

MEnstrual disturbance

Infertility

Anxiety/Depression

Metabolic disease as well as a reproductive one

24
Q

Management of PCOS

A

Lifestyle management is first line

SNAP - esp phys acitivity

5-10% weight loss

Oligomenorrhea:

COCP with 20mcg oestrogen

IF CI to COCP - medroxyprogesterone 10mg (12/28 days every month)

If prefer no hormonal - Metformin XR 500mg nocte

Hyperandrogenism

Cosmetic therapy is first line

OCP

sprionolactone 50mg (up to bd) for 3-6 months

Infertility

Weight is most important
Folate preconception

Specialist referral

Cardiometabolic risk

OGTT - 3 yearly, Lipids 2 yearly, BMI and BP checks 6 monthly.

Regular monitoring of CV risk and agressive management of risk factors

Depression/Anxiety

Manage as needed

25
Subfertility history in a male?
1. **Sexual function** - problems with erections and ejaculation 2. Age of **puberty** 3. Previous **testicular problems/injury** 4. Past history of **STIs** 5. Past Hx of **Mumps** 6. Past Hx of **urethral issues** 7. Genitourinary **surgery** (hernia? vasectomy reversal?) 8. **Occupational** history (exposure to heat, pesticides, herbicides) 9. **Meds and drug use (Etoh, smoking, substances**, anabolic steroids, sulfasalazine, spironolactone, phenytoin, etc)
26
Subfertility history in a female?
1. Onset of **menarche** 2. **Menstrual history** 3. **Symptoms of ovulation** (mittelschmerz, cervical mucous changes) 4. **Symptoms of endometriosis** (dysmenorrhea, menorrhagia, dyspareunia) 5. **PHx of STIs and Pelvic infection** 6. Previous **IUCD** use? 7. PHx of intra-abdominal **surgery** 8. PHx of genital surgery 9. **Meds and Drugs** - **ETOH, Smoking (esp over 20/day)**, past contraception esp depot provera, anabolic steroids)
27
What questions would you ask both male and female re: subfertility?
1. Time trying to concieve 2. Timing of intercourse, use of lubricants 3. Attitudes to pregnancy and subfertility 4. Expectations for the future
28
What examination findings for subfertility would you look for in man and women?
Male: 1. Secondary sexual characteristics - note any gynacomastia 2. Testicular exam - size and consistency - compare to an orchidometer (average 18ml - normal 15-35ml) - small in klinefelter - 7m 3. Palpate epidydimis and vas 4. Evidence of varicocele 5. PR -check prostate 6. Note penis and location of urethra
29
What examination findings for subfertility would you look for in woman?
Secondary sexual characterisitcis thyroid examination Note skin for acne, hirsutism Vaginal and pelvic examination - assess uterus and ovaries (present? mobile? non-tender? - normal) Check adnexae for any masses
30
How should a semen analysis be collected?
Collection should be made **directly into a sterile container after 2-3 days of sexual abstinence** If collected at home semen should be kept at body temperature during transport to the andrology lab and **should be analysed within one hour of collection.** **A repeat test in 1-3 months if the first is abnormal**
31
What investigations are required for subfertility? Man? Woman?
_Man_ **Semen analysis** _Female_ LH, FSH, Oestradiol **Mid luteal phase progesterone** - **Day 21 of 28 day cycle** (or 7 days before next period) - to confirm ovulation Serum testosterone, SHBG, Free Androgen index **TFT** **Serum prolactin** **Transvaginal ultrasound** Then refer to specialist They may go on to do tests of tubal patency like hysterosalpyngogram
32
When should infertility in couples be investigated
12 months of frequent unprotected intercourse earlier if concerns
33
What are the symptoms of acute PID?
34
How does PID present?
bleeding (at any point - during cycle (irreg/reg) or after sex) and pain PLUS acute - bilateral lower abdo pain and fever chronic - mid lower abdo pain and back pain
35
What are the diagnostic criteria for acute PID
Must have ALL of the following: 1. Lower abdo tenderness (with or without rebound) 2. Cervical motion tenderness 3. Adnexal tenderness (may be unilateral) PLUS ONE OF THE FOLLOWING: 1. Temp \>/ 38 degrees 2. Purulent fluid via culdocentesis 3. WBC over 10.5 4. ESR over 15, CRP over 1 5. Histological evidence of infection 6. isolation of neisseria g, or chlamydia
36
What pathogens cause PID?
exogenous - Chlamydia trach, n. gonno Endogenous - Ecoli Bacteroides fragilis Actinomycosis - due to prolonged IUD
37
Empirical treatment of PID
1. **Ceftriaxone 500mg** (in 2ml of lignocaine 1 %) Intramuscular or IV on its own as a single dose PLUS **Metronidazole 400mg bd for two weeks** PLUS **Doxycycline 100mg bd for two weeks**
38
If a woman presents with mucopurulent discharge, abdominal pain cervical motion or adnexal tenderness - what tests would you order?
Urine pregnancy test Urinalysis **Endocervical swabs for NAAT -** chlamydia trachomatis, neisseria gonorrhea and mycoplasma genitalium Also collect a **high vaginal swab** for M/C/S if **anal** sex - offer self collected anal swab for **chlamydia** If **sex work** identified- off **throat swab** for n. **gonorrhea** **If not a monogamous partner - syphilis serology, HIV, Hepatitis B, C**
39
Basic sexual history questions?
1. When was the last time you had sex 2. Was this a regular or a casual partner 3. How did you have sex with your most recent partner (vaginal/anal/oral) 4. Have your partners been male, female or both? 5. In the past three months how many sexual partners have you had? (Repeat question about type of sex and condom use for all partners) 6. Have you ever been diagnosed with or thought you had an STI? 7. Have you ever been paid for sex? If so when was the most recent time 8. Have you had sexual contact overseas in the last twelve months? If So which countries
40
When should a patient with PID be admitted?
Pregnant, severe symptoms has a suspicion of a pelvic abcess or cannot exclude a surgical emergency
41
What is the follow up and advice for a patient with PID
- Review treatment progress in 48 hours and then in 2 weeks for resolution of symptoms Contact tracing of all partners for last six months Follow up in 3 months - offer first pass urine test to check for re-infection
42
What are u/s findings which should be referred to a gynae?
1.Thickened endometrium pre-menopausal - greater than 12 mm post meno - greater than 5mm 2. Increased length of uterus - over 12 cm 3. Fibroid
43
What is gold standard investigation for abnormal uterine bleeding?
Hysteroscopy AND D&C
44
Pelvic causes of acute and chronic lower abdo pain
**ACUTE** Acute PID ruptured graffian follicle Ruptured ovarian cyst ovarian torsion Ectopic pregnancy Fibroid **CHRONIC** endo adeno fibroids primary dysmenorrhea chronic PID adhesions ovarian Ca
45
What is the differnetial Dx of dyspareunia?
PID endometriosis Adenomyosis Pelvic adhesions Vaginismus (Due to medical/physical/interpersonal causes)
46
What is management of Vaginismus
Differentiate difference between issue with penetrative sex and relationship issues Encourage discussion about pain, fears around intercourse, muscle tension, depression and presence or absence of sexual pleasure Broach issues of intimate partner violence and safety Encourage non penetrative sex until ready for penetration Consider sexual health therapist Review and support