Gynae3 Flashcards
(46 cards)
What are the clinical features of endometriosis?
Triad of 1) Dyspareunia 2) Dysmenorrhea (usually secondary) and 3) Menorrhagia
Often with subfertility
EXAMINATION FINDINGS
fixed retroverted uterus
Nodularity and tenderness in the pouch of Douglas
Enlarged tender uterus (main finding in adenomyosis)
How is the diagnosis of endometriosis made? Can treatment be started without it?
Gold standard is laporoscopy examination of pelvis/abdomen
for ectopic endometrial tissue
This can be supported by Pelvic ultrasound and clinical examination findings
Treatment of endometriosis
- First line - COCP and prn NSAIDs (Also wheat packs
- If contraindicated or does not improve symptom control - Progestogen only preparations are indicated
Subdermal implant, Depot injection, or POP -
Medroxyprogesterone 10mg bd for six months
or
Norethistrone 5mg bd for six months
3. GnRh agonists - eg Goserelin (dampen the hypothalamo-pituitary-ovarian axis)
4. Laparoscopy for investigation and treatment of pain - can excise focal ectopic tissue and adhesions which cause pain
At what age is oestrogen COCP and depo progesterone contraindicated?
Over 50
Which contraceptive methods are available to women in the perimenopause?
Non hormonal - if over 50 amenorrhea for one year - then cease.
If under 50 amenorrhea for two years - then cease.
Hormonal - POP, sub dermal implant, Levenorgestrel IUD
If use progestogen only and over 50 - then if FSH on two separate occasions separated by 6 weeks - is OVER 30 - then continue contraception for one year before no longer required
Features of primary dysmenorrhea?
Onset - adolescene - usually 6 to 12 months after menarche
Duration - First 2-3 days of period
No pain at other times of the menstrual cycle
No other kinds of pain
Features of secondary dysmenorrhea?
Mid to late 20s
Persists beyond first 2-3 days of period
Can have pain at other times during menstrual cycle
And other types of pain like dyspareunia
Do you need to perform a pelvic examination on a woman presenting with painful bleeding in the first few days of her menstrual cycle?
A) Young, never been sexually active - no examination needed
B) Until age of 29, sexually active women - need pelvic examination and appropriate screening - including chlamydia swab for NAAT.
When would you do investigations in dysmenorrhea?
If significant blood loss
or if symptoms suggestive of secondary cause - U/S, pregnancy test
Managment of primary dysmenorrhea
Ibuprofen 400mg tds for 48hours prior to commencement of the cycle and 2-3 days after +/- PPI
- OCP with 30mg ethinyloestradiol eg microgynon 30
- If NSAID and OCP not controlling pain - think of endometriosis and refer to specialist
- Regular exercise
- Stop smoking and reduce alcohol
- Heat pack/hot water bottle - local heat- for cramps
What is a uterine fibroid?
benign tumours of the smooth muscle of the myometrium
they can be - subserosal
intramural
subendometrial
intrauterine with a peduncle
How common are fibroids?
40-80% of women by age of 50 years
What are the symptoms of uterine fibroids?
Can be asymptomatic
Menorrhagia
metrorrhagia (Intermenstrual bleeding)
Dysmenorrhea
Infertility
Pressure symptoms - urinary frequency and hydronephrosis
Constipation
Pregnancy - First trimester bleeding, pain and miscarriage
2nd and 3rd trimester - placental abruption, pain, preterm delivery
Investigations in uterine fibroids?
- Pelvic Ultrasound
- C125 is used for monitoring treatment/post removal
Differential diagnosis for fibroids?
Uterine:
Pregnancy
Leimyosarcoma
Haematoma
Extra uterine:
Ovarian cyst
Ovarian tumour
Ectopic pregnancy
Pyosalpinx
Hydrosalpinx
Primary fallopian tube neoplasm
Pelvic abcess
Colorectal Carcinoma
Bladder carcinoma
Management of uterine fibroids?
Small, asymptomatic, young patient - monitor, no treatment
Large, young, asymptomatic - Monitor with ultrasound yearly (if patient does not want treatment)
Older age, rapidly enlarging, history of tamoxifen use - hysterectomy
Menorrhagia alone - tranexamic acid
Dysmenorrhea alone - Ibuprofen
GnRH agonist can reduce - but can cause menopause
If family completed - Hystectomy or uterine artery emboilisation - follow up with Ca 125
I
Risk factors for PCOS
Family history of PCOS
Family history of DM
ATSI or Asian women
Higher the BMI - the more likely
Key hormonal changes in PCOS
- Insulin resistance
- Hyperandrogenism
This is independent of/exacerbated by obesity
How is Free Androgen Index calculated
Free Testosterone/SHBG and multiplied by a constant (usually 100)
Any concerns about measuring FAI with OCP
OCP increases SHBG so needs three months off OCP before testing is accurate
Investigations for PCOS
Total testosterone
SHBG (will be reduced in PCOS - indicates hyperinsulinaemia)
U/S pelvis and adrenals
LH, FSH
Exclusion of secondary causes
TSH
Prolactin
Serum BHCG
17 - hydroxprogesterone (elevated in CAH)
DHEA (markedly increased in patients with adrenal tumour)
How does PCOS present?
Metabolic syndrome
hirsutism
GDM/DM
OSA
MEnstrual disturbance
Infertility
Anxiety/Depression
Metabolic disease as well as a reproductive one
Management of PCOS
Lifestyle management is first line
SNAP - esp phys acitivity
5-10% weight loss
Oligomenorrhea:
COCP with 20mcg oestrogen
IF CI to COCP - medroxyprogesterone 10mg (12/28 days every month)
If prefer no hormonal - Metformin XR 500mg nocte
Hyperandrogenism
Cosmetic therapy is first line
OCP
sprionolactone 50mg (up to bd) for 3-6 months
Infertility
Weight is most important
Folate preconception
Specialist referral
Cardiometabolic risk
OGTT - 3 yearly, Lipids 2 yearly, BMI and BP checks 6 monthly.
Regular monitoring of CV risk and agressive management of risk factors
Depression/Anxiety
Manage as needed
