gestational and placental pathology Flashcards Preview

Repro II > gestational and placental pathology > Flashcards

Flashcards in gestational and placental pathology Deck (24):
1

implantations

day 7-14

2

eclampsia

thought to be dt abnormal migration of cytotrophoblasts into spiral aa walls, therefore spiral aa do not expand properly -> HTN -> placenta releases factors into blood that causes maternal HTN

3

neutrophils in amnion

never normal
indicated infectious
if the neutrophils have infiltrated chorionic villi or if plasma cells are present indicates chronic infection

4

first trimester chorionic villi

delicate mesh of central stroma surrounded by 2 discrete layers of epi
outer layer- synctiotrophoblasts
inner layer- cytotrophoblasts

5

third trimester chorionic villi

stroma with dense network of dilated capillaries surrounded by thinned out synctiotrophoblasts and cytotrophoblasts

6

metabolic transfer

mostly thru synctiotrophoblats both passive and active transport

7

spontaneous abortion

pregnancy loss <20 weeks, but before 12

8

1st trimester causes of abortion

chromosomal

9

2nd trimester causes of abortion

mechanical

10

3rd trimester causes

fetoplacental unti

11

dichorionic

not identical

12

monochrorionic

identical

13

placenta previa

implantation on or near cervical os
blocks babys exit
presents as painless bleeding in 3rd trimester
Most common cause of antepartum hemorrhage
C-section

14

abruptio placenta

dt premature separation of placenta -> clot
painful, may or may not bleed
emergency

15

placenta accreta

attachment of placenta to myometrium
loss of decidua basalis
does not seperate after delivery
hysterectomy requires
uterine rupture in 15%
accreta< increta< percreta
c-section or other scarring major risk factors

16

placental infection

ascending or from maternal

17

acute chorioamnionitis

vaginal flora ascends -> loss of mucous plug -> travels thr membranes to umbilicus -> ascent to fetus

18

preeclampsia/eclamsia

HTN >20weeks gestation
associated with proteinuria and edema
common in premigravida women >35

19

pathophys of eclamsia

maternal endothelial dysfunction d/t underprofussion of placenta d/t abnormal adaptation of spiral aa to pregnancy

20

HELLP

hemolysis
elevated liver enzymes
low platelets

21

complete hydotidiform mole

arise from fertilization of empty ovum
no fetal parts
billous edema with diffuse trophoblastic proliferation
high risk of chrioCA

22

partial hydrotidiform mole

2 sperm fertilizing single ovum
identifiable fetal parts

23

when should you suspect gestational neoplasm

when uterus too large for date and no fetal heart beat/movement
HTN
thryrotoxicosis
painless bleeding

24

choriocarcinoma

arise from complete hydatidiform moles (50%), previous abortions (25%), normal pregnancies (22%)
Beta-hCG MARKEDLY elevated
lack villous strucutes
mets to lungs, vagina, brain, liver
chemo almost 1000% cure-rate
methotrexate