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Flashcards in pharm of prego Deck (28):
1

drug transfer across placenta

dependent upon lipid solubility and polarity

2

thiopental

barbituate used in C-sections
rapdily crosses placenta

3

succinylcholine and tubocurarine

used in C-sections
highly charged and cross placenta slowly

4

heparin

safe togive in prego

5

warfarin

crosses placenta and is teratogenic

6

what tissues can be effected by drugs differently during prego

repro- breast and uterus

7

what tissues are not effected differently during prego?

heart
lungs
kidneys
CNS

8

examples of fetal Rx

corticosteroids to stimulate lungs
antiarrhythmics
zidovudine to prevent HIV transmission

9

diethylstillbestol

increased risk for adenocarcinoma when child get to puberty

10

teratogen characteristics

drug use results in characteristic set of malformations
exerts effects at particular stage of fetal development
dose-dependent incidence

11

antiemetics

pyridoxine
antihistamines
dopamine antagonists
serotonin antagonisits
glucocortiocoids

12

pyridoxine

vit B6
precursor to pyridoxal increases GABA synthesis

13

antihistamines

anticholinergic activity
doxylamine most common used in combo with pyridoxine

14

when do you Tx preeclampsia with antiHTN

>150/100

15

antiHTNs for preeclampsia

labetalol
hydralazine (aa not vv)
nifedipine and nicardipinde (block LCaChs

16

what should NOT be used to Tx HTN in prego

ACE inhibitors
angiotensin R blockers
direct renin inhibitors

17

what should be used to Tx preexisitng HTN

labetalol
methyldopa
nifedipine
thiazide diuretics

18

thiazide diuretics ADR

hypokalemic metabolic alkalosis
hyperglycemia
hyperlipidemia
hyponatremia

19

Tx of GDB

insulin
lispro and aspart

20

tocolytics

beta agonists
magnesium sulfate
CaCh blockers
COX inhibitors

21

beta agonists

tachyphylaxis
ritodrine most commonly used
many adverse effects - tachy, low BP, bronchial relaxation

22

magnesium sulfate

unknown MOA- possibly interferes with mysoin light-chain kinase
few adverse effects (diaphoresis and flushing)
CI in MG

23

CCBs

questionable safety

24

COX inhibitors

Indomethacin most commonly used
reduced PGs
primary fetal concerns is constriction of ductus arteriosus and oligohydramnios

25

induction of labor

oxytocin
vaginal PGs

26

oxytocin MOA

sitmulates uterine mm contraction via Gq -> stimualtes release of PGs and leukotrienes
also causes milk ejection

27

opioids

does cross placenta dn decreased FHR and respirations

28

neuroaxial analgesics

spinals and epidurals