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Flashcards in GI 3 Deck (187)
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1

Functions of liver

carb, fat, steroid, protein metabolism

detoxification

prodution & excretion of bile

storage iron, vit K, minerals blood

2

yellow pigmentation of sclera, skin, deeper tissues

jaundice

3

why does jaundice happen

due to a concentration of bilirubin in blood, becomes abnormally increased

4

how is bilirubin formed

from the breakdown of hemoglobin of old RBC's

(unconjugated bilirubin released into blood, bound to albumin, not water soluable (cannot be excreted) cannot be filitered by kidneys, builds up in blood)

5

what does the bilirubin level have to be for jaundice to occur

3 times greater than normal

6

is jaundice a disease

NO, its a symptom

7

what is the most common cause of jandice

excessive breakdown of RBC's or bile excretion obstruction

8

babies become jaundice because

of excessive destruction of RBC's

9

results from excessive RBC destruction, occurs before the liver, has excess unconjugated bilirubin

pre-hepatic jaundice (hemolytic)

10

causes of hemolytic jaundice

hemolytic anemia, sickle cell, severe burns, newborns

11

defective uptake, conjugation or excretion of bilirubin within liver, both unconjugated and conjugated bilirubin elevated

hepatic jaundice (hepatocellular)

12

causes of hepatocellular jaundice

cirrhosis, hepatitis, hepatic carcinoma

13

what is the major problem in hepatocellular jaundice

conjufation and excretion of bilirubin

14

decreased or obstructed flow of bile thru liver or biliary duct system, blocks outward flow of bile from liver

post hepatic jaundice (obstructive)

15

obstruction of bile into the duodenum, clay colored stools with complete obstruction

extrahepatic

16

pruritis

itching

17

who would you have a pt come in with a bleeding problem who has a Hx of liver disease

lack of vit K, bile is necessary for absorption of vit k from GI

18

what Rx do you want to avoid if you have problems with jaundice

ASA, risk of bleeding

19

any type of inflammation in the liver

hepatitis

20

what kind of hepatitis is most common

viral hepatitis

21

wide spread inflmmation of liver, liver cell damage, degeneration and necrosis, bile flow interruption

viral hepatitis

22

what are causes of hepatitis

viral

alcohol

drugs

23

Hepatitis A

transmitted thru fecal oral route

occurs in small outbreaks

contagious for 2 weeks prior to symptoms

due to poor hygine, contaminated food, water, poor sanitary conditions

24

detection of IgM anti-HAV indicates

acute hepatitis

25

presence of IgG antibody does what

provides lifelong immunity

26

Hepatitis B

can live up to 7 days on a dry surface, 100x's more infectious than HIV

transimission by body fluids, blood

 

27

HBV Window phase

have a 3 month delay between disapperance HB-antigen & apperance Anti-HB

28

a positive HBAb or anti-HBs indiciates

recovery, no longer contagious

immunity from HBV vaccine or past HBV infection

29

Hepatitis C

transmission is blood & blody fluids

HCV damages liver over decades

leading indication for liver transplant

chronic, asymptamatic

30

only way for survival of hepatitis c is

liver transplant