GI - 5 Liver Disease pt 2 Flashcards Preview

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Flashcards in GI - 5 Liver Disease pt 2 Deck (24)
1

Sensitive and precise marker of viral replication and infectivity
Small amounts can persist long after recovery.
Tells how much of the virus is in their blood

HBV DNA

2

Hep _ only exists with Hep _

Hep D only exists with Hep B

3

Progression from acute to chronic hepatitis B is primarily determined by:

the age at infection. Having Hep B since a child – highest chance of going on to have Chronic Hep B

4

The persistence of which HBV antigen in the blood indicates carrier state?

HBsAg

5

What does carrier state mean?

chronic disease

6

in terms of hep B and D,
What does coinfect mean?
what does superinfect mean?
Which is worse?

Coinfect: D & B come together
Superinfect: already have B and then D - worse

7

Treating Hep C depends on ___

the genotype

8

Most are anicteric and asymptomatic with mild course
Jaundice:

Hep C

9

How do you check if someone cleared Hep C?

check for Antibody for Hep C Virus: if they have it it means they should be tested for the viral load. If they don’t have viral load, then they cleared it.

10

Having Anti HCV in blood ___ mean recovery

Having Anti HCV in blood: DOES NOT MEAN RECOVERY ******

11

What is the treatment for Hep C/ Chronic Hep C? (2)

Interferon alpha
Peginterferon

12

Treatment for Hep C is reserved for:

Often treatment is reserved for patients whose serum HCV RNA levels fail to clear after 3-4 mos

13

If a patient is AntiHCV+ you can assume they are no longer infections
True
False

False. You have to do the viral load

14

What Hep is this?
Self limited illness and NO CARRIER STATE***
High mortality rate in pregnant women(10-20%)***
Not in the USA

Hep E

15

What 2 types of Hep have no carrier state?

Hep A and E have no carrier state (if you carry it you will show symptoms)

16

Describe the 4 general phases of Hepatitis

1. Prodromal phase: Malaise, myalgias, arthralgias, fatigability , URI symptoms, anorexia
Nausea, vomiting, diarrhea, or constipation (vague)
+/- Serum sickness in acute HBV
Fever is low grade if any (except HAV)
RUQ or epigastric abdominal pain
2. Icteric phase: Jaundice occurs after 5-10 days if at all
May occur with prodromal symptoms
3. Convalescent phase – getting better
4. Course & Complications: Hepatitis B, D, C, G may become chronic**
A&E do not become chronic

17

What general phase of Hepatitis is this?
Prodromal phase: Malaise, myalgias, arthralgias, fatigability , URI symptoms, anorexia
Nausea, vomiting, diarrhea, or constipation (vague)
+/- Serum sickness in acute HBV
Fever is low grade if any (except HAV)
RUQ or epigastric abdominal pain

1. Prodromal phase

18

What general phase of Hepatitis is it when Jaundice may occur?

2. Icteric phase

19

Which general phase of Hepatitis involves getting better, getting an appeitite back and such?

3. Convalescent phase

20

What types of Hepatitis may become chronic? Which do not?

Hepatitis B, D, C, G may become chronic**
A&E do not become chronic

21

4 signs of hepatitis

Hepatomegaly
Liver tenderness
Splenomegaly
Lymphadenopathy - Cervical and epitrochlear

22

___ often precedes jaundice

Bilirubinuria

23

A general lab finding for Hep is

High ALT/AST

24

How do you prevent getting Hep A from someone who has it?

Immune globulin should be given to all close contacts and persons who consume food prepared by infected individual