GI

Question 1

Peptic ulcer recurrent rates

Answer 1

85% if H. pylori not removed, 5-15% recurrence if it is removed

Question 2

bismuth, metronidazole, tetracycline, PPI

Answer 2

Quadruple H. pylori Tx

Question 3

PPI, amoxicillin or metronidazole, clarithromycin

Answer 3

Triple regiment

Question 4

worsening dementia symptoms

Answer 4

anticholinergic drugs like Dicyclomine (Bentyl) can cause

Question 5

H1

Answer 5

mediate allergic responses

Question 6

H2

Answer 6

stimulate gastric acid secretion

Question 7

H3

Answer 7

CNS neurotransmission

Question 8

H4

Answer 8

mast cell chemotaxis

Question 9

Cimitidine, Ranitidine, Nizatidine, Famotidine

Answer 9

H2s from lowest to highest

Question 10

inhibits CYP 450

Answer 10

Cimetidine drug interactions

Question 11

PPI

Answer 11

most powerful HCI secretion suppressors

Question 12

C. diff, low levels of magnesium, osteoporosis, cv disease

Answer 12

Long term PPI issues

Question 13

suppress acid production, stimulate mucin production, increase bicarb, increase mucosal blood flow

Answer 13

gastric effects of prostaglandins

Question 14

misoprostol

Answer 14

prostaglandin agonist contraindicated in pregnancy

Question 15

aluminum hydroxide, magnesium hydroxide, calcium carbonate

Answer 15

antacid tablets

Question 16

renal failure

Answer 16

antacid tablets are contraindicated in ___

Question 17

loperamide

Answer 17

opiate analog with an anticholingeric effects can cause toxicmegacolon in kids and avoid use in severe colitis

Question 18

largely protective (4) things: suppress acid production, stimulate mucin, increase bicarb, increase mucosal blood flow

Answer 18

action of gastric prostaglandins

Question 19

metabolic alkalosis

Answer 19

why do you not use bicarb in neutralizing acid?

Question 20

mucusal protectants, 1 hr before

Answer 20

sucralfate, bismuth and how to take

Question 21

Phenothiazine, Substituted Benzamides, Butyrophenones, Benzo, Cortosteroids, Cannabinoid Receptor Agonsist, Serotonin,Sustance P

Answer 21

anti-emetics

Question 22

prolonged QT interval

Answer 22

What is the most concerning anti-serotonin side effect?

Question 23

appetite suppression and weight loss

Answer 23

amphetamine side effects

Question 24

high body temperature

Answer 24

serontonin syndrome main symptom

Question 25

autonomic nervous system

Answer 25

involuntary, unconscious nervous system

Question 26

atonic colon

Answer 26

what is the most concerning irritant/stimulant laxative side effect

Question 27

colloids, saline cathartics; water retention and intestinal distention

Answer 27

what are the types of bulking agents and how do they work?

Question 28

chloride channel activators

Answer 28

prostaglandin derivative that stimulates intestinal fluid secretaions; used in chronic constipation and IBS w/ constipation

Question 29

antimotility agents and absorbents

Answer 29

antidiarrheal drug classes

Question 30

near 4th ventricle outside of BB barrier, medulla, afferents, cortex inpus, peripheral inputs

Answer 30

what are the 5 emetic control centers?

Question 31

tron

Answer 31

what is the ending of the anti-serotonin 5HT drugs?

Question 32

corticosteroids, cannabinoid, benzodiazepines

Answer 32

other drugs useful for nausea

Question 33

cholinergic agents, dopamine receptor antagonists, serotonin receptor modulation, motilin-like agents

Answer 33

GI motility agents- prokinetics

Question 34

agonists, and acetycholinesterase inhibitors

Answer 34

how do the cholinergic agents work?

Question 35

metoclopramide

Answer 35

dopamine receptor antagonist that helps with GI motility and migraines

Question 36

Cisapride, metoclopramide, ondansetron

Answer 36

serotonin receptor modulators

Question 37

macrolide abx like: erythromycin, oleandomycin, azithromycin - diabetic gastroparesis, expel bezoars clarithromycin

Answer 37

what are the motilin like agents are when are they indicated

Question 38

metformin, GLP-1. sodium-glucose cotransporter 2 inhibitors

Answer 38

type 2 diabetic agents that help with modifiying metabolism

Question 39

orlistat

Answer 39

lipase inhibitor what work to modify metabolism

Question 40

amphetamine derivatives, serotonin receptor agonists, anti-convulsants

Answer 40

anorectic drug classes

Question 41

chronic pain, quit smoking, weight loss

Answer 41

atypical anticonvulsant uses

Question 42

morbid obesity, failure of lifestyle modifications

Answer 42

when to use anorectic agents