Immuno, Arthritis

Question 1

What are the components of the immune system?

Answer 1

innate and adaptive

Question 2

What are the two key problems with immunosuppression?

Answer 2

opportunistic infections, increased cancer risk

Question 3

This allergic response causes acute symptoms but gives defense against parasites.

Answer 3

mast cell degranulation

Question 4

What are other uses of first generation of antihistamines?

Answer 4

prevent motion sickness/vertigo, sedation/hypnosis, antiemetic

Question 5

Problems with antihistamines

Answer 5

sedation, dry mouth, tachy, HTN

Question 6

This antimetabolites is used for organ transplants, RA and can cause opportunistic infections and sepsis

Answer 6

mycophenolate mofetil

Question 7

This is an excessive release of cytokines

Answer 7

cytokine storm

Question 8

This cytokine inhibitor is used in organ transplants and RA, danger is nephrotoxicity

Answer 8

cyclosporine

Question 9

This cytokine inhibitor is more effective than cyclosporine but is also more toxic, danger are kidney and neuro toxicities

Answer 9

tacrolimus

Question 10

This cytokine inhibitor is used in graft vs. host infections, may cause hyperlipidemia

Answer 10

sirolimus

Question 11

These 1st generation antihistamine are readily available over the counter

Answer 11

Chlorpheniramine, diphenhyrdramine, doxylamine

Question 12

This immuno-antibody drug is prepared from murine or equine sources, infused slowly, and repetitive use can cause antibody response in pt.

Answer 12

antithymocyte globulins

Question 13

This immuno-antibody is pooled immunoglobulins from 1000s of donors, effects last 2-3 mos.

Answer 13

IVIG

Question 14

This immuno-antibody is derived from mice and antibodies produced bind to any targeted molecule

Answer 14

Monoclonal Antibodies

Question 15

What is Omalizumab used for?

Answer 15

Pt with severe asthma

Question 16

Monoclonal antibody against HER-2

Answer 16

Trastuzumab

Question 17

suffix for monoclonal antibody

Answer 17

-mab

Question 18

prefix for monoclonal antibody

Answer 18

dealers choice except Muro

Question 19

infix target of -mabs:
tumor
Circulation
neural
immune

Answer 19

• tu-
• ci- or -cir-
• neu-
• li- or -lim-

Question 20

infix type of -mabs:
chimeric
humanized

Answer 20

• xi-

- zu-

Question 21

interlukin-2 receptor blocerks

Answer 21

Basiliximab, daclizumab

Question 22

depletion of t lymphocyte drugs

Answer 22

alemtuzumab

Question 23

tumor necrosis factor-alpha blockers

Answer 23

infliximab and adlimumab

Question 24

Glucocorticoids used for RA giving symptom relief but can lead to long term toxicity

Answer 24

Prednisone, methylprednisolone

Question 25

Gold sodium thiomalate, aurothioglucose, Auranofin are types of

Answer 25

gold salts

Question 26

Gold adversities and tx

Answer 26

dermatitis, proteinuria, blood dyscrasis tx: stop tx, halflife awareness, Dimercaprol

Question 27

This antimalarial agent used in RA can cause GI upset and exacerbate gold related dermatitis

Answer 27

Chloroquine

Question 28

Major Chloroquine concerns (2)

Answer 28

1. retinopathy | 2. cardiac conduction disturbances

Question 29

This RA drug is quite toxic and is reserved for difficult cases

Answer 29

D-Penicillamine

Question 30

This immunosuppressive DMARD is an antimetabolite and antifolate sensitive on rapid dividing cells used in cancer, severe psoriasis, early pregnancy termination

Answer 30

Methotrexate

Question 31

What are 3 of methotrexate's toxicities?

Answer 31

liver, bone marrow suppression, mucosal ulceration

Question 32

This immunosuppressive DMARD slows lymphocyte mitosis, reduces pain and swelling, reduces disease progression

Answer 32

Leflunomide

Question 33

This TNF receptor mediates autoimmune related inflammation

Answer 33

alpha

Question 34

This is a TNF receptor seen in infection & tumor surveillance function

Answer 34

beta

Question 35

3 TNF-alpha blockers

Answer 35

Adalimumab, Etanercept, Infliximab

Question 36

This TNF-alpha blocker is used when all else has failed

Answer 36

Etanercept

Question 37

Etanercept adversity and long term safety issues

Answer 37

injection site irritation; infections, neoplasms

Question 38

This is a chimeric IgG, monoclonal against TNF_alpha, used in Crohns for 6 wks

Answer 38

Infliximab

Question 39

These drugs block uric acid production

Answer 39

allopurinol, febuxostat

Question 40

This drug is anti-inflammatory effects reducing pain in 12-24 hrs but can cause diarrhea and is being replaced by NSAIDS

Answer 40

Colchicine

Question 41

What drug needs avoided with Colchicine?

Answer 41

Aspirin, Macrolide Abx

Question 42

These uricosuric agents block uric acid reabsorption from proximal tubules and is well tolerated with some GI upset

Answer 42

Probenecid, sulfinpyrazone