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Flashcards in GI pharmacology Deck (26)
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1

Which drug class does 'ompeprazole' belong to and what is it used for?

Proton Pump Inhibitor
- GORD, dyspepsia, H.pylori eradication

2

Which drug class does 'aluminium/magnesium hydroxide' belong to and what are they used for?

Antacids
- GORD and dyspepsia

3

Which drug class does 'Ranitidine' belong to and what is it used for?

H2 receptor antagonists
- Dyspepsia, peptic ulcers and GORD

4

What are the 4 classes of laxatives/ purgatives used to treat constipation?

Bulk laxatives
Stimulant purgatives
Faecal softeners
Osmotic laxatives

5

What is the drug 'Loperamide' used to treat?

It is an anti-motility drug used for symptomatic relief of diarrhoea (non-infective/ traveller's diarrhoea)

6

What are dopamine receptor antagonists, e.g Droperidol, used to treat?

Emesis
- drug induced/ GORD/ gastroparesis

7

What are muscarinic Ach antagonists used to treat? Give an example of a drug

Emesis - motion sickness and IBS
e.h Hyoscine

8

What are H1 antihistamines, e.g cyclizine, used for?

Emesis - motion sickness, morning sickness, PONV

9

What are prokinetic drugs e.g metroclopramide used to treat?

GORD
gastroparesis

10

What is an example of a 5 H3 receptor antagonists used for anti-emesis?

Ondansetron

11

What 4 classes of drugs are used in the treatment of ulcerative colitis?

5 ASA
Corticosteroids
Immunosuppressants
Anti-TNF therapy

12

What 3 classes of drugs are used in the treatment of Crohn's Disease?

Corticosteroids
Immunosuppressants
Anti-TNF therapy

13

What is an example of an immunosuppressant used to treat UC or Crohn's?

Azathioprine

14

Infliximab is a drug used to treat UC and Crohn's Disease, which drug class does it belong to?

Anti-TNF therapy

15

Sulphasalazine can be used to treat Ulcerative Colitis, to which drug class does it belong?

5 ASA

16

Which corticosteroids can be used to treat Ulcerative Colitis and Crohn's Disease?

Prednisolone and Budesonide

17

What are mucosal strengtheners, e.g sucralfate used to treat?

GORD
Ulcers

18

When are adjuvant antiemetics used?
Give an example of a drug class

To decrease emesis in patients who are undergoing chemotherapy and are unresponsive to the other anti-emetic drug classes
CANNABINOIDS e.g Nabilone

19

Which receptors for emesis are present at the vomiting centre in the medulla and what are their neurotransmitters?

H1 (histamine) M1/M3 (acetylcholine) 5HT3 (serotonin)

20

Which receptor for emesis is present in the pharynx and the GI tract and what is its neurotransmitter?

5HT3 (serotonin)

21

Which receptors for emesis are present within the chemoreceptor trigger zone and what are the neurotransmitters for each of these?

M1 (acetylcholine)
H1 (histamine)
5HT3 (serotonin)
Opioid (morphine)
D2 (dopamine)

22

Which emetic receptors are present within vestibular nuclei and what are the neurotransmitters for each of these?

H1 (histamine)
M1 ( acetylcholine)

23

Which two anti-emetic drug classes act on the vomiting centre in the medulla?

H1 antagonists and Antimuscarinic drugs

24

Which two anti-emetic drug classes act on vestibular nuclei?

H1 antagonists and Antimuscarinic drugs

25

Which two anti-emetic drug classes act on the chemoreceptor trigger zone?

DA antagonists and 5HT3 antagonists

26

Which class of drugs act on 5HT3 receptors in the pharynx and the GI tract?

Chemotherapy and radiotherapy drugs