Glomerular Disease in Adults Flashcards
Injury to glomerular epithelial cells via cytokines released by monocytes
Minimal change disease
Focal Segmental glomerulosclerosis
IC formation, Complement activation in subepithelial space; deposition of extra GBM material
Membranous glomerulonephritis
IC formation, complement activation in subendothelial space or mesangium
Post-infectious Glomerulonephritis
IgA Nephritis
SLE Nephritis
Circulating Abs against GBM
RPGN - Goodpasture’s
Circulating Ab against neutrophil cytoplasm Ags
ANCA
Polyangitis
RPGN
VAsculitis
- Kid comes in w/ Hx Hodkins Lymphoma + new onset oliguria and edema
Minimal change disease
60 YO white male w/ HTN, RA, proteinuria, + Oliguria. Pathology? What would you see under microsopic eval
Membranous Nephropathy - PA2R Ab which deposit subepithelial and show a “spike and Dome” deposit
Membranous Nephropathy Tx
- Loop blockers (Edema)
- Statins (dyslipidemia)
- RAAS block (HTN)
- Immunosuppressives (controversial)
African American male w/ proteinuria, HTN, hematuria, Micriscopy shows pdocyte effacement.
Focal segmental glomerulosclerosis
FSGS PAth
T-cell mediated circulating permeability factor, TGF-β-mediated cellular proliferation and matrix synthesis, genetic mutation-> podocyte abnormality
Isolated hematuria or heavy proteinuria
Hypercellularity w/ tram tracking of GBM
MPGN
35 YO White male w/ episodic macroscopic hematuria. Mesangial IC deposits. A/S Celiac/ Dermherp
IgA Nephritis
- Hypercellularity of mesangium
- PMH infiltrate
- subepithelial deposits
- Low C3
PSGN
SLE ACR Criteria
SOAP BRAIN MD
Serositis
Oral Ulcers
Arthritis
Photosensitivity
Blood/anemia/lymphopenia Renal ANA Immune/serologies Neurologic
Malar Rash
Discoid Rash
WHO Lupus Nephritis Classifications
Type I: Normal Glomeruli
Type II: variable mesangial hypercellularity, INC matrix, immune deposits
Type III: Focal proliferative Disease w/ GBM + mesangial deposits
Type IV: Diffuse proliferative lesions
Type V: Diffuse membranous lesions w/ subepithelial immune deposits
