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Flashcards in Glycopeptides Deck (10)
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1

Name two Glycopeptide drugs.

1. Vancomycin
2. Teicoplanin

2

What is the MOA of Vancomycin (include elimination)?

- Bactericidal
- Inhibits cell wall synthesis by binding to D-alanine end of peptidoglycan pentapeptide

- 80-90% excreted in urine

3

How is Vancomycin administered?

- Slow IV infusion (poorly absorbed orally and IM painful)

4

What is the MOA of Teicoplanin?

- Bactericidal
- Inhibits cell wall synthesis by binding to D-alanine end of peptidoglycan pentapeptide

(same as Vancomycin)

5

How is Teicoplanin administered?

- IV
- IM (painful)

6

What spectrum are both Vancomycin and Teicoplanin?

* Reserve antibiotic for treatment of life threatening infections only

- Cloxacillin-resistant staphylococci
- Penicillin-resistant enterococci
- Penicillin allergic patients with infective endocarditis
- GIT infections by oral administration (pseudomembranous colitis - C. difficile)

7

What are the side effects of Vancomycin?

- Fever, skin rashes
- Red man syndrome (rapid admin causes histamine release)
- Ototoxic
- Nephrotoxic

8

What drug interactions occur with Vancomycin or Teicoplanin?

- Ototoxic and nephrotoxic drugs (aminoglycosides)

9

What is contra-indicated with Vancomycin or Teicoplanin?

- Renal impairment
- Elderly
- Neonates
- Hearing abnormalities
- Pregnancy

10

What are the side effects of Teicoplanin?

- Fever, skin rashes, allergy
- Cross-hypersensitivity with Vancomycin
- Red man syndrome (less likely than with Vancomycin)
- Ototoxic
- Nephrotoxic