Carbapenems Flashcards Preview

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Flashcards in Carbapenems Deck (7)
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1
Q

Name two Carbapenem drugs.

A
  1. Imipenem

2. Meropenem

2
Q

What is the general MOA of Carbapenem drugs (Imipenem and Meropenem)?

A
  • Same as Penicillin

- Bactericidal

3
Q

How are Carbapenems (Imipenem and Meropenem) administered?

A
  • IV
4
Q

What spectrum is Imipenem and what is it used to treat?

A
  • Very broad spectrum (Gram +ve, Gram -ve and anaerobic)
  • Not active against MRSA
  • Treats: severe nosocomial infections
5
Q

What drug interactions occur with Imipenem?

A
  • Imipenem + Cilastin = block renal metabolism
6
Q

What spectrum is Meropenem and what is it used to treat?

A
  • Broad

* Meningitis alternative treatment (good CSF penetration)

7
Q

What are the general side effects of Carbapenems (Imipenem and Meropenem)?

A
  • Hypersensitivity reactions, GIT issues, haematological effects
  • CNS effects (penetrates CSF)
  • Increases liver enzymes, serum creatinine and urea
  • Red discolouration of urine in children
  • IV admin: thrombophlebitis, erythema and pain
  • Imipenem: seizures