Carbapenems

Question 1

Name two Carbapenem drugs.

Answer 1

1. Imipenem

2. Meropenem

Question 2

What is the general MOA of Carbapenem drugs (Imipenem and Meropenem)?

Answer 2

• Same as Penicillin

- Bactericidal

Question 3

How are Carbapenems (Imipenem and Meropenem) administered?

Answer 3

• IV

Question 4

What spectrum is Imipenem and what is it used to treat?

Answer 4

• Very broad spectrum (Gram +ve, Gram -ve and anaerobic)
• Not active against MRSA
• Treats: severe nosocomial infections

Question 5

What drug interactions occur with Imipenem?

Answer 5

• Imipenem + Cilastin = block renal metabolism

Question 6

What spectrum is Meropenem and what is it used to treat?

Answer 6

• Broad

* Meningitis alternative treatment (good CSF penetration)

Question 7

What are the general side effects of Carbapenems (Imipenem and Meropenem)?

Answer 7

• Hypersensitivity reactions, GIT issues, haematological effects
• CNS effects (penetrates CSF)
• Increases liver enzymes, serum creatinine and urea
• Red discolouration of urine in children
• IV admin: thrombophlebitis, erythema and pain
• Imipenem: seizures