Carbapenems Flashcards Preview

Pharmacology > Carbapenems > Flashcards

Flashcards in Carbapenems Deck (7)
Loading flashcards...
1

Name two Carbapenem drugs.

1. Imipenem
2. Meropenem

2

What is the general MOA of Carbapenem drugs (Imipenem and Meropenem)?

- Same as Penicillin
- Bactericidal

3

How are Carbapenems (Imipenem and Meropenem) administered?

- IV

4

What spectrum is Imipenem and what is it used to treat?

- Very broad spectrum (Gram +ve, Gram -ve and anaerobic)
- Not active against MRSA

* Treats: severe nosocomial infections

5

What drug interactions occur with Imipenem?

- Imipenem + Cilastin = block renal metabolism

6

What spectrum is Meropenem and what is it used to treat?

- Broad

* Meningitis alternative treatment (good CSF penetration)

7

What are the general side effects of Carbapenems (Imipenem and Meropenem)?

- Hypersensitivity reactions, GIT issues, haematological effects
- CNS effects (penetrates CSF)
- Increases liver enzymes, serum creatinine and urea
- Red discolouration of urine in children
- IV admin: thrombophlebitis, erythema and pain

- Imipenem: seizures