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Flashcards in Sympathetic NS Deck (50)
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0

List 4 SNS pure agonist drugs

Phenylephrine
Alpha methyldopa
Dopamine
Salbutamol

1

What receptor does Phenylephrine act upon?

Alpha 1

2

What receptor does Alpha methyldopa act upon?

Alpha 2

3

What receptor does Dopamine act upon?

Beta 1

4

What receptor does Salbutamol act upon?

Beta 2

5

List 4 SNS non-specific Agonist drugs

Ephedrine
Amphetamine
Cocaine
Adrenaline

6

List 4 SNS blockers

Doxazosin
Atenolol/bisoprolol
Propanolol
Carvedilol

7

Name which receptor Doxazosin act upon?

Alpha 1

8

What receptor does Atenolol/Bisoprolol act upon?

Beta 1

9

What receptor does Propanolol act upon?

Beta 1 and beta 2

10

What receptor does Carvedilol act upon?

Alpha 1, beta 1 and beta 2

11

Which drugs act upon alpha 1 receptors and what are their respective MOA?

Phenylephrine - SNS pure a1 agonist
Doxazosin - SNS a1 blocker
Carvedilol - SNS a1,b1,b2 blocker

12

Which drugs act upon alpha 2 receptors and what are their respective MOA?

Alpha methyldopa - SNS pure a2 agonist

13

Which drugs act upon beta 2 receptors and what are their respective MOA?

Dopamine - SNS pure b1 agonist
Atenolol/Bisoprolol - SNS b1 blocker
Propanolol - SNS b1,b2 blocker
Carvedilol - SNS a1,b1,b2 blocker

14

What are the therapeutic effects of Phenylephrine and what it is used to treat?

Vasoconstriction
Increases blood pressure
Maybe mydriasis

* Topical to nose

- conjunctivitis
- allergy rhinitis
- flu (decongestant)

16

What are the therapeutic effects of Alpha Methyldopa and what it is used to treat?

Decreases TPR

* Twice daily. Liver metabolism.

- Hypertension
- Hypertension due to pregnancy!

17

What are the therapeutic effects of Dopamine and what it is used to treat?

Increases CO (increases conductivity of SA node and increases contractility)
Increases renal perfusion

* IV use.

Cardiogenic shock (increase CO and HR)

18

What are the therapeutic effects of Salbutamol and what it is used to treat?

Bronchodilation in airways
Stops uterine contractions

Asthma and COPD
Premature labour


19

What are the therapeutic effects of ephedrine and what it is used to treat?

Vasoconstriction
Increase CO
Increase HR
Increase vessel resistance

* Weaker than amphetamine
* Doesn't cross blood-brain barrier easily

Oral congestion (oral decongestant)

20

What is the MOA of phenylephrine?

Mimics the effects of NA and Adren. on a1 receptors in vascular smooth muscle
Increases blood pressure by vasoconstriction (can be used locally to do so)

21

What is the MOA of alpha methyldopa?

Decreases presynaptic release of Na in the vasomotor centre of the brain thus increasing SNS effects
Decreases TPR (total peripheral resistance) but leaves other reflexes intact.

22

What is the MOA of dopamine?

Mimics effects of neurotransmitters on b1 in heart and JG cells of kidney
Increases levels of cAMP
Increases O2 demand in heart
Increases conduction through the SA node

23

What is the MOA of salbutamol?

Mimics action of adrenaline on b2 receptors in lungs, blood vessels, pregnant uterus and liver
Increases relaxation of smooth muscle (by increasing cAMP levels)

24

What is the MOA of ephedrine?

Mimics the effects of NA and Adren. on the b1 receptors in the heart and JG cells.
Increases SNS by increasing synaptic neurotransmitters
Released presynaptically by NA

25

What are the therapeutic effects of amphetamine and what it is used to treat?

Increases SNS effects

* Addictive (drug of abuse)

26

What is the MOA of amphetamine?

Mimics the effects of NA and Adren. on the b1 receptors in the heart and JG cells.
Increases SNS by increasing synaptic neurotransmitters (it is released presynaptically by NA)
Stimulates NA in the brain which increases dopamine levels there (addiction)

27

What are the therapeutic effects of cocaine and what it is used to treat?

Increases SNS effects

* Addictive (drug of abuse)

28

What is the MOA of cocaine?

Mimics the effects of NA and Adren. on the b1 receptors in the heart and JG cells.
Increases SNS by increasing synaptic neurotransmitters as it is a re-uptake inhibitor
Stimulates NA in the brain which increases dopamine levels there (addiction)

29

What is the MOA of doxazosin?

Blocks the binding of NA to the peripheral a1 adrenergic receptors
Competitive antagonist
Blocks SNS reflex after postural changes

30

What is the MOA of atenolol/bisoprolol?

Blocks the effects of NA and Adren. on b1 receptors
Pure antagonist
Blocks b-cells in brain
Increases renin release in JG cells
Blocks conduction through AV node and SA node
Decreases contractility and O2 demand in heart

* Cardioselective
* Loses b1 selectivity at higher doses (starts blocking b2)