Flashcards in Renal Deck (6)
Name the 6 drug groups that are diuretics.
1. Carbonic Anhydrase Inhibitors
2. Thiazide Diuretics
3. Loop Diuretics
4. Potassium Sparing Diuretics
5. Osmotic Diuretics
6. ADH Analogue
List 4 factors that predispose the kidney (nephron) to toxicity?
1: Increased blood flow of all organs (large blood volume passes through it)
2: Drug and chemical mixing which leads to drug interactions
3: Reabsorption of water causing the concentration of toxins
4: Proximal convoluted tubule secretes drugs/organic toxins
Name the 6 toxin induced pathogenic mechanisms in the nephron.
1: Altered glomerular hemodynamics
2: Tubular cell toxicity (decreased mitochondrial function, oxidative stress, free radicals and transport interference)
3: Inflammation (nephritis)
4: Crystal nephropathy
6: Thrombotic Microangiopathy
Name the 4 clinical presentation of nephrotoxicity.
1: Acute Kidney Injury (AKI)
2: Nephrotic Syndrome
3: Renal Tubular Dysfunction
4: Chronic Renal Failure
List 4 things that increase a person's susceptibility to nephrotoxins.
1: Intravascular restriction (RAAS and PG system activation)
2: Decreased available normal tissue recovery (females and Chronic Kidney Diseases)
3: Genetic variation
4: Inflammation response