GONADOTROPINS + GnRH

Question 1

GnRH agonists → mechanism of action:

Answer 1

1. suppress gonadotropin release (LH & FSH) → by down-regulation of GnRH receptors in the ant. pituitary
2. suppress production of gonadal steroid hormones (estrogen, androgen)

Question 2

GnRH agonists: (drug names)

Answer 2

1. goserelin
2. histrelin
3. leuprolide
4. nafarelin

Question 3

GnRH agonists → indications:

Answer 3

1. prostatic cancer
2. endometriosis
3. precocious puberty (= child going into puberty too fast)

Question 4

GnRH agonists → CONTRAindications:

Answer 4

1. PREGNANCY

2. breast feeding

Question 5

GnRH agonists → side effects in WOMEN:

Answer 5

1. hot flushes
2. sweating
3. decreased libido
4. depression
5. ovarian cysts

Question 6

GnRH agonists → side effects in MEN:

Answer 6

1. initially → raise testosterone that can lead to bone pain
2. hot flushes
3. edema
4. gynecomastia
5. diminished libido

Question 7

GONADOTROPINS: (drug names)

Answer 7

1. menotropin
2. follitropin
3. urofollitropin
4. hCG (= human chorionic gonadotropin)
5. choriogonadotropin

Question 8

GONADOTROPINS → mechanism of action:

Answer 8

1. regulate gonadal steroid hormones

2. ovarian follicular growth & maturation + ovulation

Question 9

GONADOTROPINS → indication:

Answer 9

INFERTILITY!!

Question 10

GONADOTROPINS → side effects:

Answer 10

1. ovarian enlargement
2. possible ovarian hyperstimulation syndrome (may be life-threatening)
3. multiple births