Granulocyte Flashcards
(21 cards)
Granulocytes are produced from ……………
Pluripotent hematopoietic stem cell
The fundamental roles of granulocytes include the following
Defence
Recognition and destruction of neoplastic cell
Role in acute inflammation
Phagocytosis of apoptotic and scenescent cells hence play a role in tissue repair and remodeling
The development of wbc along different lineage is governed by external stimuli which include ……………. and ……………
Cytokines
Matrix protein
Cellular factors within the bone marrow
List the roles of phagocytes
All WBC roles including
Modulating cellular and humoral immunity through synthesis and release of immunoregulatory proteins and cytokines and have a role in allergy and inflammation
List the roles of phagocytes
All WBC roles including
Modulating cellular and humoral immunity through synthesis and release of immunoregulatory proteins and cytokines and have a role in allergy and inflammation
The factors that regulate leukopoiesis include
IL1
IL3
IL5
IL6
GMCSF
GCSF
MCSF
Neutrophil constitutes about …………. percent of circulating leukocytes
65%
The the reserve pool spends …….. to ………… hours before moving into circulation
6-10
The the reserve pool spends …….. to ………… hours before moving into circulation
6-10
The life span of the granulocyte in the bone marrow is ………
4-5days
The primary granules of neutrophils appear at ………….. stage while the secondary appears at …………..
Promyelocytic stage
Myelocitic stage
At what stage of development are the primary granules produced?
Premyeolocytic
Primary granules include …………… ……..
Secondary granules…………… ………….
Myeloperoxidase
Acid hydrolase
Secondary granules
Lactoferrin
Lysozyme
Eosinophils secrete the following cytokines
IL1 IL3 IL6 IL8 TNFB
List the function of eosinophil
Expantiate
Hypersensitivity reaction
Extracellular matrix deposition
Extracellular matrix degradation
Release of cytokines
Toxicity to bacteria
Amplifying inflammatory response
What is a left shift in white blood cells
Increased ratio of immature wbc to mature usually band form
What Is the normal neutrophil associated phosphatase score
20-100
Causes of leukaemoid reaction
Severe and chronic infection
Severe haemolysis
Metastatic cancer
Frequent change in the blood count that is indicative of neutrophilia is …………
A rise in neutrophils in circulation above 7.5×10^9/L
List the causes of leukoerythroblastic reaction
Myeloma
Lymphoma
Severe hemolysis
Severe megaloblastic anaemia
Metastatic neoplasm in bone marrow
Acute and chronic myeloid leukaemia
Primary myelofibrosis
Osteoporosis
Causes of eosinophilia include….
Parasitic infection: hook worm, amoebasis
Allergic diseases: bronchial asthma, hay fever
Skin diseases
