Myeloid Leukaemias Flashcards
(19 cards)
AML despite its predominant occurrence in adults is the predominant congenital leukaemia in neonatal period and it’s commonly associated with ……..
Down syndrome
AML is commonly associated with ….. virus
HTLV1
Causes of AML include……….
Idiopathic commonest
Myeloproliferative disorders i.e MDS, PNH, MF PRV
Viruses
Chemicals
Ionizing radiation
Drugs
Hereditary disorders; Downs klinfelter, fanconi’s frequently higher in monozygotic twins than dizygotic twins
The AML associated with thrombocytopenia or DIC is …….
AML M3
The symptoms of AML.are
Marrow failure
Tissue infiltration
Leukostasis
Constitutional symptoms
Bleeding tendency
State the FAB classification of AML
M0 - acute myeloblastic cells with minimally differentiated or undifferentiated cells
M1 -AML with differentiated cells
M2 - with matured cell
M3- Acute promyelocytic leukaemia with hypergranular
M3 variant- hypogranular bilobed
M4 - Acute myelomonocytic leukemia
M4 Eo- Acute myelomonocytic leukaemia with eosinophilia
M5 a - Acute monoblastic cells undifferentiated
M5b-acute monoblastic differentiated
M6 - erythroleukaemia
M7- Acute megakaryoblastic leukaemia
WHO classification is based on ………..
- AML with recurrent genetic abnormalities
- AML with multi -lineage dysplasia
- AML and MDS therapy related
- Uncategorized
- Ambiguous
List the acute leukaemia of ambiguous lineage
Undifferentiated acute leukaemia
Bilineal AL
Biphenotypic AL
List the uncategorized AML
M0, M1,M2,M5,M4,M5 , M6,M7
acute basophilic leukaemia
Acute panmyeolosis with Myelofibrosis
Myeloid sarcoma
List the therapy related AML
Alkylatin agent or radiation related type
Topoisomerase II inhibitor-related maybe lymphoid related
List the AML.with multilineage dysplasia
Following MDS
Or without antecedent MDS but at least 50% dysplasia cells in 2 or more lineage of myeloid cells
List the AML with recurrent genetic abnormalities
AML t(8;21) (q22;q22)
AML with abnormal bone marrow eosinophils - inv 16 p13 q22
Acute promyelocytic leukemia AML t 15 17 q23 q12
AML 11q23
In AML bone marrow is ………
Hypercellular
Gingivitis is association with ……. class of AML
M3
Serum and urinary lysozyme are raised in ………………
Monocytic leukaemia
List the specific tests for AML
Special cytochemical stains +very for AML -ve for ALL
Non specific esterase positive only for monocytic
Acid phosphatase +ve for all
Serum and urinary lysozymes positive on for monocytic cells
Immunological markers
The special cytochemical stains in AML are
Sudan black
Myeloperoxidase
Esterase chloroacetate and nonspecific esterase
