Platelet Flashcards
(15 cards)
Vit K dependent clotting factors are
Factors 2,7,9,10 protein C and S prothrombin
The magakaryocyte is about ………… in size
The earliest recognizable precursor is
50um
BFU mg
Magakaryocyte is produced from BFU-meg under the influence of
Thrombopoietin
IL3
IL11
The final defragmentation of magakaryocyte occurs in …….
Lungs
The duration for production of platelets from stem cell is …….
10 days
Each megakaryocyte gives rise to about
1000- 5000 platelets
The half life of platelets are
8-14days
About ………… % of platelets are sequestered in the spleen
20-30%
Normal platelet count is …….
100-300 / 150-400 ×10^9/L
The number of dense and alpha per platelet are ……… and ………. respectively
7
80
The granules are released through ……….. system
Canalicular system
The platelet glycoprotein belong to two well defined family which are
Leucine-rich GP family
Integrins
Gp1c -11a binds to
Fibronectin for platelet spreading , fibroblast attachment to vessel wall
GP1v and GP V binds to ……. and is for
Thrombospodin
V is hydrolysed by thrombin Thrombin, adrenaline
For platelet aggregation
The platelet membrane contain phospholipids which are concern with
Prostaglandin secretion
Calcium mobilisation within the cell
Localisation of procoagulant activity on the outer surface of platelets
