Myeloproliferative Disorders

Question 1

A
What is the aetiopathogenesis of PV

Answer 1

Almost 100% of the patients have jAK 2 mutations ( heterozygous or homozygous)

Deletions of 9p or 20q in the minority of the patients

Question 2

JAK 2 mutation is the replacement of ………. with …….. on long arm of chromosome 9

Answer 2

Valine with phenylalanine