Hemapoiesis

Question 1

What is reactive neutrophilia and what determines it presence

Answer 1

Infection induced neutrophilia

1. Left shift
2. Dohle bodies
3. Toxic granules
4. High neutrophil activated phosphatase score

Question 2

List the causes of neutropenia

Answer 2

Congenital : kotmanns syndrome

Acquired
Drug induced
Anti inflammatory drug
Aminopyrine phenylbutazone
Anti bacterial: chloramphenicol
cotrimazole
Anti convulsant : phenytoin
Carbamezapine

● immune : sle felty’s syndrome
● splenomegaly
●bone marrow failure
●large granar lymphocytic leukaemia
●infection: influenza , his, hepatitis

Question 3

Due to short life span of the blood cells about …….. needs to be produced daily.

Answer 3

10^13

Question 4

2/3rd of mass function of red bone morrow is dedicated to ……………
1/3rd is dedicated to …………..

Explain

Answer 4

White blood cells
Red blood cells
Due to the high rate of turnover of white blood cells

Question 5

The embryonic hematopietic stem cells were discovered where?

Answer 5

Mesenchymal cells of embryonic yolk sac

Question 6

The definitive stem cells were discovered where?

Answer 6

AGM aorta-gonads-mesonephros

Question 7

The stem cell ( hemangioblast) are believed to have seeded the following organs …….. …….

Answer 7

Liver
Spleen
Thymus
Bone marrow

Question 8

Blood production after birth takes place in all bone marrow in the first………. years

Answer 8

2-3 years

Question 9

The three major things that regulate or home the blood cells in an environment where it can be regulated are

Answer 9

Cytokines
Adhesion molecule
Endothelial cells

Question 10

The stem cells are in a quiescent state and this is maintained by

Answer 10

Growth factor
TGFB
Transforming growth factor beta

Question 11

List the characteristics of growth factors involved in haemopoiesis