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Flashcards in Gut Immunity - Shnyra Deck (30)
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1

Paneth cells job

Production of defensins - antimicrobial

2

M cells job

Luminal antigen sampling, transport intact Microbes and hand off to DC

3

Plasma cells job

Produce IgA cells

4

Mucins job and location

glycosylated proteins made by mucosal epithelial cells

5

Epithelial cells express which TLRs

TLR 2 4 5 6 7 9

6

How does commensal microflora control inflammation?

Inhibition of NF-kB

7

Characteristics of GALT

Microvilli
Tight junctions
Secrete mucins to make glycocalyx
Antimicrobial peptides
M cells
APCs in subepithelial dome

8

What type of cell for the dominant protective cell-mediated immune response?

Th17
-most numerous

9

Major form of adaptive immunity in gut that is directed at microbes in lumen is?

IgA
-IgG and IgM in lumen

10

Major mechanism for controlling responses in gut is?

Treg cells

11

Lamina propria contains?

IgA and IgM plasma cells

12

Microflora symbiosis

Balanced
Maintains homeostasis

13

Microflora dysbiosis

Dysregulation of immune system and inflammation
Due to enviro

14

What shapes gut microbiota?

Diet
It adapts to diet and changes the nutritional value
Microbiota and immune system co-evolve

15

Dietary IL?

IL-10
Regulates metabolic activités in lamina propria

16

2 immune-mediated food allergies?

1. Type I - IgE mediated
2. Type III/IV - Non-IgE mediated

17

4 things related to non-immune mediated food tolerance?

Pharmacological
Enzymatic
Psychosomatic
Irritant

18

Are you gonna ace this exam?

FUCK yes you are. You amazing beautiful smart future doctor!

19

2 phases of allergic inflammation

1. sensitization induction
2. effector phase

20

Oral challenge of sensitized individual leads to

Th2 inflammation and allergen induced diarrhea

21

IL's associated with allergic diarrhea

IL - 4, 13, 9

22

Food induced anaphylaxis

Mast cells activated by IgE
Mediators released that induce symptoms include histamine and platelet activating factor

23

What mediates anaphylaxis to casein?

Ig free light chains

24

Mediates peanut induced anaphylaxis?

IgG1 - induced activation of macrophages

25

How else can IgE-mediated mechanisms contribute to shock?

Production of C3a

26

C3a job

Stimulate macro, baso and mast cells

27

6 examples of food intolerance

Absence of an enzyme
IBS
Food poisoning
Sensitivity to food additives
Recurring stress
Celiac disease

28

In celiac disease, what creates potent immunostimulatory epitopes?

Transglutaminase 2
Presented via HLA-DQ2 or HLA-DQ8

29

Myofibroblasts in celiac

Remodel mucosal and villus atrophy

30

Which IL links adaptive to innate immunity?

IL-15