Flashcards in Liver Function I - Seidler Deck (15)
What goes into forming isoprenoids
3 Acetyl CoA's come together to form Isopentenyl pyrophosphate (IPP) - (active isoprene) that serves as the building blocks for the synthesis of all isoprenoids
What is the building blocks of isoprenoids?
Isopentenyl pyrophosphate (IPP)
3 groups of isoprenoids
1. Steroids - cholesterol, bile acids, steroid hormones
2. Lipid-soluble vitamins - A,D,E,K
3. Other - ubiquinone, dolichol, heme tails, lipid anchors
What can arise due to abnormalities in the synthesis and processing of lipoproteins?
Hyperlipoproteinemias (typically elevated cholesterol) or hypolipo-proteinemias (typically decreased cholesterol)
All steroids contain?
- four rings combined
Examples of steroids
How are sterols different?
They are steroid molecules with hydroxyl groups
Structural features of cholesterol?
27 carbon molecule
17 C make up sterane ring
Which precursor of cholesterol is a linear structure?
What is the fate of cholesterol in all tissues?
Cholesterol is incorporated into cellular membranes
What is the fate of cholesterol in liver?
Cholesterol used to synthesize bile acids
What is the fate of cholesterol in adrenal glands, ovaries and testes?
Cholesterol used to synthesize steroid hormones
Fate of cholesterol in skin?
Used to synthesize vitamin D
Effect of statins?
Competitively inhibit HMG CoA reductase (HMGR)