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Flashcards in Liver Function I - Seidler Deck (15)
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1

What goes into forming isoprenoids

3 Acetyl CoA's come together to form Isopentenyl pyrophosphate (IPP) - (active isoprene) that serves as the building blocks for the synthesis of all isoprenoids

2

What is the building blocks of isoprenoids?

Isopentenyl pyrophosphate (IPP)

3

3 groups of isoprenoids

1. Steroids - cholesterol, bile acids, steroid hormones
2. Lipid-soluble vitamins - A,D,E,K
3. Other - ubiquinone, dolichol, heme tails, lipid anchors

4

What can arise due to abnormalities in the synthesis and processing of lipoproteins?

Hyperlipoproteinemias (typically elevated cholesterol) or hypolipo-proteinemias (typically decreased cholesterol)

5

All steroids contain?

Sterane ring
- four rings combined

6

Examples of steroids

Cholesterol
Estradiol
Cholic acid

7

How are sterols different?

They are steroid molecules with hydroxyl groups

8

Structural features of cholesterol?

27 carbon molecule
17 C make up sterane ring

9

Which precursor of cholesterol is a linear structure?

Squalene

10

What is the fate of cholesterol in all tissues?

Cholesterol is incorporated into cellular membranes

11

What is the fate of cholesterol in liver?

Cholesterol used to synthesize bile acids

12

What is the fate of cholesterol in adrenal glands, ovaries and testes?

Cholesterol used to synthesize steroid hormones

13

Fate of cholesterol in skin?

Used to synthesize vitamin D

14

Effect of statins?

Competitively inhibit HMG CoA reductase (HMGR)

15

Bile salt and cholesterol

Micelles, essential for absorption of lipids and lipid-soluble vitamins by intestinal cells