Lipid Metabolism (In Class)- Agbas Flashcards Preview

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Flashcards in Lipid Metabolism (In Class)- Agbas Deck (44)
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1

what does citrate do in synthesis of acetyl CoA?

supplies carbons for FA synthesis

2

what is the primary source of fatty acid synthesis?

liver

3

what is the first phase of fatty acid synthesis?

cytosolic entry of acetyl CoA

4

what is the second phase of fatty acid synthesis?

conversion of acetyl CoA to Malonyl CoA

5

what are the 2 parts of the third phase of fatty acid synthesis?

elongation and desaturation

6

what is the rate limiting step in fatty acid synthesis?

acetyl CoA to malonyl CoA conversion

7

malonyl coA is important because?

it's substrate for FA synthesis, regulates FA synthesis and is an immediate donor of the 2C units

8

how are fatty acid synthesized?

2Cs added at a time

9

what are the 3 goals achieved during phase 3?

condensation, reduction, and palmitate release

10

where is palmitate elongated?

in the smooth ER

11

what is required for desaturation?

NADPH and O2

12

where are double bonds put in during desaturation?

4, 5, 6, and 9

13

what cannot be generated endogenously for desaturation?

10 and beyond; must be taken in dietarily

14

what is the source of NADPH?

malic enzyme (1), pentose phosphate pathway (2-12 NADPH)

15

what are the ways in which FAS can be regulated?

allosteric effect (phosphorylated sugars) and induction and/or repression at genetic level

16

what does a high carb/low fat diet do to FAS?

increases

17

high fat diet and starvation does what to FAS?

lowers FAS

18

how are FAs stored in adipocytes?

triacylglycerol

19

what is the structure of triglycerols?

3 FAs attached to glycerol backbone

20

what are TGs synthesized?

liver, intestinal cells, and adipose tissue

21

where in the cell does TG synthesis occur?

cytosol

22

how are FAs transported in blood?

chylomicrons

23

what is the common aspect of TG synthesis in the 3 tissue?

Fatty acyl coA

24

what are the 3 main lipases in adipocytes?

hormone-sensitive lipase, lipoprotein lipase, and mono glycerol lipase

25

what is the most active enzyme in fasting state?

hormone-sensitive lipase

26

fatty acids are transported from adipocytes to liver in blood by?

albumin

27

where does Beta-ox of fatty acids occur?

mito matrix in liver cells

28

what are the 2 phases of beta oxidation?

1) transport of FFA into mito matrix and 2) beta-oxidation of FA

29

CPTI is negatively regulated by?

malonyl CoA

30

where does activation of LCFA occur?

cytosol