Haem Misc. Flashcards Preview

Jason's MD2 Surgery Rotation > Haem Misc. > Flashcards

Flashcards in Haem Misc. Deck (21):
1

how does immune thrombocytopenia provocation?

Meds (Quinine, antimalarials)
viral (EBV, CMV, HIV)
lymphoproliferative disorders (B cell - non-hodgkin)
connective tissue disorders (SLE)

idiopathic(most cases)

2

immune thrombocytopenia in children need bone marrow?

no, usually resolves on its own

3

how to treat immune thrombocytopenia?

steroids
IVIg
Anti-CD20 (B-cell marker) (Rituximab)
splenectomy
thrombopoietin receptor agonist

4

give platelets for immune thrombocytopenia?

not primarily, only in emergency because only lasts 5 minutes

5

Thrombotic thrombocytopenic purpura (TTP) classic pentad?

thrombocytopaenia
microangiopathic haemolytic anaemia
neurologic abnormalities
renal failure
fever

6

Thrombotic thrombocytopenic purpura (TTP) triad in practice?

thrombocytopaenia
schistocytosis
elevated lactate dehydrogenase

7

Thrombotic thrombocytopenic purpura (TTP) trigger?

idiopathic

pregnancy
e.coli infection
malignancy

8

pathophysiology of Thrombotic thrombocytopenic purpura (TTP)?

abundant von willebrand factor, but no fibrin

diminished cleaving of high molecular weight parts of vWf ADAMTS13 and you get clots in various organs

9

how to treat Thrombotic thrombocytopenic purpura (TTP)?

plasma exchange against fresh frozen plasma

10

other Thrombotic thrombocytopenic purpura (TTP) treatments besides FFP?

aspririn & dipyrimadole
splenectomy
steroids

11

myelodysplasia is?

clonal haematologic disorder
marrow is less effective: quantity and qualitative
less than 20% myeloblasts

12

what are the 3 myeloproliferative disorders

polycythemia rubra vera
essential thrombocythaemia
myelo fibrosis
CML

13

myelodysplasia affects which cells? why is is dangerous?

neutrophils number could be normal, function stuffed.
platelets number normal: function stuffed

14

neutrophils look how in myelodysplasia?

lack of granules, strange nuclear lobes

15

how to dx myelodysplasia?

bone marrow biopsy

16

myelodysplasia can transform to?

AML
Acute Myeloid Leukaemia

17

who gets myelodysplasia?

older ppl

18

how do you know myelodysplasia is transforming AML?

more and more blasts

19

immune thrombocytopenia happens how?

anti-platelet antibodies

20

When do you use anion gap?

in metabolic acidosis

21

When would anion gap be useful? 4 causes?

DKA
Poisons
renal failure
lactic acidosis

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