Flashcards in Haem Misc. Deck (21):
how does immune thrombocytopenia provocation?
Meds (Quinine, antimalarials)
viral (EBV, CMV, HIV)
lymphoproliferative disorders (B cell - non-hodgkin)
connective tissue disorders (SLE)
immune thrombocytopenia in children need bone marrow?
no, usually resolves on its own
how to treat immune thrombocytopenia?
Anti-CD20 (B-cell marker) (Rituximab)
thrombopoietin receptor agonist
give platelets for immune thrombocytopenia?
not primarily, only in emergency because only lasts 5 minutes
Thrombotic thrombocytopenic purpura (TTP) classic pentad?
microangiopathic haemolytic anaemia
Thrombotic thrombocytopenic purpura (TTP) triad in practice?
elevated lactate dehydrogenase
Thrombotic thrombocytopenic purpura (TTP) trigger?
pathophysiology of Thrombotic thrombocytopenic purpura (TTP)?
abundant von willebrand factor, but no fibrin
diminished cleaving of high molecular weight parts of vWf ADAMTS13 and you get clots in various organs
how to treat Thrombotic thrombocytopenic purpura (TTP)?
plasma exchange against fresh frozen plasma
other Thrombotic thrombocytopenic purpura (TTP) treatments besides FFP?
aspririn & dipyrimadole
clonal haematologic disorder
marrow is less effective: quantity and qualitative
less than 20% myeloblasts
what are the 3 myeloproliferative disorders
polycythemia rubra vera
myelodysplasia affects which cells? why is is dangerous?
neutrophils number could be normal, function stuffed.
platelets number normal: function stuffed
neutrophils look how in myelodysplasia?
lack of granules, strange nuclear lobes
how to dx myelodysplasia?
bone marrow biopsy
myelodysplasia can transform to?
Acute Myeloid Leukaemia
who gets myelodysplasia?
how do you know myelodysplasia is transforming AML?
more and more blasts
immune thrombocytopenia happens how?
When do you use anion gap?
in metabolic acidosis