Surgical Tut - colorectal tut Flashcards Preview

Jason's MD2 Surgery Rotation > Surgical Tut - colorectal tut > Flashcards

Flashcards in Surgical Tut - colorectal tut Deck (25):
1

APC controls what?

B-catenin production

2

FAP is? why does it happen?

familial adenomatous polyposis
>100 polyps
has two hits already

3

HNPCC
Hereditary non polyposis colon cancer is what?

lynch syndrome

4

HNPCC caused by what?

microsatellite instability
DNA mismatch repair

5

HNPCC, lynch can cause what cancers?

small bowel
gall bladder
colon
endometrial

6

gardener syndrome is?

subtype of FAP: skin tags all over

7

different polyps?

pedunculated
sessile

8

FAP vs. HNPCC polyps different?

FAP - clear polyp
HNPCC - subtle, not as obvious

9

symptoms of bowel cancer?

PR bleeding
iron deficiency
constipation/diarrhoea
abdo pain, obstipated (no farts)

10

how much iron in a litre of blood?

500mg of iron

11

how much iron do you absorb a day?

10mg per day

12

what is obstipated?

not passing wind

13

obstruction symptom

stop passing wind
distension
empty PR

14

what causes gasses in large bowel

Nitrogen
swallowing air
bacteria gas production

15

why does caecum perforate?

thinner wall
open and close loop
more tension on wall: ischaemia

16

how can bowel perforate re: cancer?

gas distention
ulcerated cancer

17

how to investigate bowel cancer?

colonoscopy

18

when does adenoma become adeno-carcinoma?

invasion past lamina propria

19

3 places colon cancer spreads

liver
lungs
nodes

20

ways to scan for colon

CT c/a/p
MRI

21

difference in rectal and colon cancer rx?

rectal are fixed
radiotherapy has better chance to
neoadjuvant

22

what does neo-adjuvant mean?

chemo and radio before a surgery to decrease size

23

TMN staging for colon cancer?

T- depth stage
T1 - not through muscularis
T2- low rate
T3 - 20% mets
T4 - almost definitely mets
M - metastasis
N - Nodes

24

what chemo for bowel cancer?

Folfox

25

colorectal cancer risks?

APC gene
Adenomatous polyposis coli

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