Pathology - Lymph Nodes 2 Flashcards Preview

Jason's MD2 Surgery Rotation > Pathology - Lymph Nodes 2 > Flashcards

Flashcards in Pathology - Lymph Nodes 2 Deck (21):
1

plasmacytoma is?

solitary,
no bone marrow involvement
no hypercalcaemia

2

multiple myeloma is?

bone marrow involvement
multi-focal

3

who gets multiple myeloma?

males>females
>age 70

4

consequence of multiple myeloma?

prone to thrombi due to increase viscosity

5

multiple myeloma, what to look for in urine?

Bence Jones proteins

6

renal manifestations of multiple myeloma?

renal stones: hypercalcaemia
infection
cast nephropathy (Bence Jones stuck in tubules)
neoplastic infiltration
amyloidosis

7

what is amyloidosis?

pathologic extracellular protein: misfolding of proteins into B-pleated sheets, and deposit in organ(s)

8

where does amyloidosis deposit?

GIT (most) rectal
tongue
heart
kidneys
lungs
nerves
skin
spleen
liver
thyroid
soft tissue

9

difference between primary or secondary amyloidosis?

primary: plasma cell, MGUS, light chains, often lambda, multiple organ deposits (AL Type)
secondary: systemic inflammatory, TB (AA type)

10

risk of amyloid angiopaphy?

cerebral haemorrhage

11

where is amyloid angiopathy?

in the vessel wall, could look like vasculitis

12

endocrine amyloid?

thyroid
islets of langerhan

13

amyloidosis does what to organs?

cardiac: restrictive, arrythmia
renal: nephrotic syndrome and failure

14

classic stain for amyloid?

Congo Red Stain

15

white pulp in spleen contains?

B-zone: germinal centre,mantle, marginal zones
T-zone: around arteriole

16

what is red zone in the spleen?

blood vessels

17

causes of hypersplenism?

cysts
congenital
acquired
autoimmune
lymphoma
amyloid

18

sarcoid granuloma is what?

non caseating granuloma

19

lymphoma has rise in white or red pulp in spleen?

white pulp

20

macro of hodgkin lymphoma look like?

beefy red with around with atrophic white pulp

21

Plasma cells look like?

clock-face nuclei
eccentric round nuclei

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