Flashcards in Pathology - Lymph Nodes 2 Deck (21):
no bone marrow involvement
multiple myeloma is?
bone marrow involvement
who gets multiple myeloma?
consequence of multiple myeloma?
prone to thrombi due to increase viscosity
multiple myeloma, what to look for in urine?
Bence Jones proteins
renal manifestations of multiple myeloma?
renal stones: hypercalcaemia
cast nephropathy (Bence Jones stuck in tubules)
what is amyloidosis?
pathologic extracellular protein: misfolding of proteins into B-pleated sheets, and deposit in organ(s)
where does amyloidosis deposit?
GIT (most) rectal
difference between primary or secondary amyloidosis?
primary: plasma cell, MGUS, light chains, often lambda, multiple organ deposits (AL Type)
secondary: systemic inflammatory, TB (AA type)
risk of amyloid angiopaphy?
where is amyloid angiopathy?
in the vessel wall, could look like vasculitis
islets of langerhan
amyloidosis does what to organs?
cardiac: restrictive, arrythmia
renal: nephrotic syndrome and failure
classic stain for amyloid?
Congo Red Stain
white pulp in spleen contains?
B-zone: germinal centre,mantle, marginal zones
T-zone: around arteriole
what is red zone in the spleen?
causes of hypersplenism?
sarcoid granuloma is what?
non caseating granuloma
lymphoma has rise in white or red pulp in spleen?
macro of hodgkin lymphoma look like?
beefy red with around with atrophic white pulp