Haematology Flashcards
(26 cards)
What is the test of choice for hereditary spherocytosis?
EMA binding test
What is the reversal agent for dabagitran?
idarucizumab
Which parameters are used to monitor haemochromatosis?
Transferrin sat & serum ferritin
What is the MOA of rasburicase?
Converts uric acid to allantoin
Prolonged APTT suggests a problem with which pathway?
Intrinsic
Prolonged PT suggests a problem with which pathway?
Extrinsic (or common)
Which clotting factors are involved in the intrinsic pathway?
8, 9, 11 and 12
Which clotting factors are involved in the extrinsic pathway?
7 only
Which clotting factors are involved in the common clotting pathway?
1, 2, 5 and 10
What are the most common manifestations of VWD?
Mucocutaneous manifestations - nose, mouth, periods, bruising
What is the role of VW factor?
carries F8 around the body
How is VWD inherited?
AD
What is the usual Tx for VWD?
Lifestyle advice
Replacement usually reserved for those with severe VWD or during surgery (F8 concentrate)
Haemophilia A occurs due to deficiency of…
Factor 8
Haemophilia B (Christmas Disease) occurs due to deficiency of…
Factor 9
Haemophilia C (Rosenthal Syndrome) occurs due to deficiency of…
Factor 11
How is Haemophilia inherited?
A and B - X-linked recessive, C = AR
What are the main treatments for Haemophilia A?
recombinant F8 (3 times daily) or Evicuzumab (SC twice weekly)
What is the mechanism of thrombophilia in Factor V Leiden?
Resistance to Protein C
What is the most common presentation of myelofibrosis?
Lethargy
What is the most common inherited thrombophilia?
Factor V Leiden / activated protein C resistance
Is CLL usually B or T cell?
99% B cell
How is systemic mastocytosis diagnosed?
Urinary histamine
Which marker is useful in predicting prognosis in MM?
B2-microglobulin
