MRCP Part 1 > Rheumatology > Flashcards

Rheumatology Flashcards

(49 cards)

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1
Q

Which HLA locus is associated with psoriatic arthritis?

A

HLA B27

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2
Q

Hereditary angioedema results from deficiency in…

A

C1-INH

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3
Q

What are the indications for steroid initiation in sarcoidosis?

A

parenchymal lung disease, uveitis, hypercalcaemia and neurological or cardiac involvement

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4
Q

Which type of cryoglobulinaemia is associated with Raynaud’s phenomenon?

A

Type 1 only

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5
Q

Ehlers’ Danlos Syndrome is caused by a defect in which types of collagen?

A

Type III or V

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6
Q

Osteogenesis imperfecta is caused by a defect in which type of collagen?

A

Type I

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7
Q

What is the MOA of Methotrextate?

A

Reversible inhibition of dihydrofolate reductase

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8
Q

What is the MOA of Denosumab?

A

RANKL inhibitor

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9
Q

‘bone within a bone’ appearance suggests…

A

Osteopetrosis

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10
Q

Increased fracture risk with low serum calcium, low serum phosphate, raised ALP and raised PTH suggests…

A

Osteomalacia

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11
Q

Which antibody is associated with dermatomyositis?

A

Anti-Jo-1

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12
Q

Which antibody is most associated with mixed connective tissue disease?

A

Anti-RNP

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13
Q

What is the mainstay of Tx for Paget’s diseae?

A

Bisphosphonates

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14
Q

Joint effusion with ‘double contour’ sign suggests…

A

Gout

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15
Q

GPA is most associated with which auto-antibody?

A

cANCA (PR3)

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16
Q

EGPA is most associated with which auto-antibody?

A

pANCA (MPO)

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17
Q

Which auto-antibody is most associated with polymyositis?

A

Anti-Jo-1

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18
Q

Which auto-antibody is most associated with diffuse cutaneous systemic sclerosis?

A

Anti-Scl-70

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19
Q

Which auto-antibody is most associated with limited cutaneous systemic sclerosis?

A

Anti-centromere

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20
Q

Which autoantibody is most specific for RA?

21
Q

Which autoantibody is most specific for SLE?

22
Q

What is scleroderma?

Study These Flashcards
A

Tightening/fibrosis of skin without organ involvement

23
Q

CREST syndrome is a sub-type of…

Study These Flashcards
A

Limited cutaneous systemic sclerosis

24
Q

Which type of cutaneous systemic sclerosis has greater mortality?

25
What is the main cause of mortality in diffuse cutaneous systemic sclerosis?
Lung disease - ILD or PAH
26
What chemical mediator is mainly responsible for the tissue oedema seen in patients in hereditary angioedema?
Bradykinin
27
HLA-DRB1is associated with...
RA
28
Which factors predispose to development of gout?
Increased production - alcohol, haem malignancy, chemo, severe psoriasis Decreased excretion - CKD, diuretics
29
Needle-shaped negatively bifringent crystals suggests...
Gout
30
How should a first episode of gout be managed?
NSAIDs/colchicine Offer urate lowering therapy such as allopurinol or febuxostat
31
Which factors predispose to the development of psuedogout?
Advanced age, haemochromatosis, Wilson's disease, acromegaly, hyperparathyroid, low Mg/PO4
32
Negatively bifringent rhomboid crystals suggests...
Pseudogout
33
Give examples of large vessel vasculitis.
Temporal arteritis/GCA Takayasu's arteritis
34
Young woman with unilateral absent upper limb pulse suggests...
Takayasu's arteritis
35
What is the investigation of choice for Takayasu's arteritis?
MRA or CTA
36
Which virus is associated with polyarteritis nodosa?
Hep B
37
Give examples of medium vessel vasculitis.
Polyarteritis nodosa Kawasaki disease
38
Fever, arthralgia, mononeuritis multiplex, livedo reticularis suggests..
Polyarteritis nodosa (PAN)
39
How is Kawasaki disease treated?
High-dose aspirin and IVIg
40
What is the most serious complication of Kawasaki disease?
Coronary artery aneurysm
41
sensorimotor polyneuropathy and positive Hep B serology suggests..
Polyarteritis nodosa
42
Which type of collagen is associated with vEDS?
Type 3
43
Which agent may be used for treating hereditary angioedema?
Anabolic steroids such as Danozol
44
What is the treatment for refractory Still's disease?
Anakinra
45
Which XR finding is more associated with RA than OA?
Periarticular osteopaenia
46
Which movement is classically impaired in adhesive capsulitis?
External rotation
47
Which antibody is most specific to dermatomyositis?
Anti-Mi-2
48
What is the strongest predictor for thrombosis in anti-phospholipid syndrome?
Presence of lupus anticoagulant
49
Give features of poor prognosis in RA
rheumatoid factor positive anti-CCP antibodies poor functional status at presentation X-ray: early erosions (e.g. after < 2 years) extra articular features e.g. nodules HLA DR4 insidious onset
MRCP Part 1
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