Flashcards in Haemopoiesis Deck (95)
What is haemopoiesis?
Formation of BLOOD cells
What is the name for mature red cells?
Do mature red cells (erythrocytes) have a nucleus?
What is the function of erythrocytes?
Do platelets have a nucleus?
What is the role of platelets?
They are involved in primary haemostasis
Formation of the platelet plug
Name the 3 groups of white cells.
* Monocytes - macrophages
Name the 3 granulocytes.
What do neutrophils have a role in?
Phagocytosis and acute inflammation
What do eosinophils do?
* Destroy parasites.
* Modulate hypersensitivity reactions.
What do basophils do?
Modulate hypersensitivity reactions
What is the main type of monocyte?
What do macrophages do?
Modulate immune reactions, involved in phagocytic clearance, regulatory functions
Name the 3 types of lymphocyte.
* B cells
* T cells
* NK cells
What are the 3 types of lymphocyte? And what are they involved in?
B cells – humoral immunity (antibodies).
T cells – cell-mediated immunity, regulatory functions.
Natural killer (NK) cells – anti-viral/tumour.
What is erythropoiesis?
Production of red cells
What is thrombopoiesis?
Production of platelets
What is myelopoiesis/granulopoiesis?
Production of bone marrow and all the cells that arise with it
What is lymphopoeisis?
Production of lymphocytes
In a steady state ....
Cell loss is balanced by cell production
What is the lifespan of red cells?
What is the lifespan of neutrophils?
What is the life span of platelets?
How many red cells are lost and produced per minute?
How many neutrophils are lost and produced per minute?
How many platelets are lost and produced per minute?
What do mature cells come from?
What cell is formed just before the reticulocyte? What is the difference between these?
The late normoblast – contains a nucleus which is lost to form the reticulocyte
The late normoblast has a nucleus but when it becomes a reticulocyte it loses the nucleus but keeps some RNA