Flashcards in Haemopoiesis Deck (95)
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1
What is haemopoiesis?
Formation of BLOOD cells
2
What is the name for mature red cells?
Erythrocytes
3
Do mature red cells (erythrocytes) have a nucleus?
NO
4
What is the function of erythrocytes?
O2/CO2 transport
5
Do platelets have a nucleus?
NO
6
What is the role of platelets?
They are involved in primary haemostasis
Formation of the platelet plug
7
Name the 3 groups of white cells.
* Granulocytes
* Monocytes - macrophages
* Lymphocytes
8
Name the 3 granulocytes.
* Neutrophils
* Eosinophils
* Basophils
9
What do neutrophils have a role in?
Phagocytosis and acute inflammation
10
What do eosinophils do?
* Destroy parasites.
* Modulate hypersensitivity reactions.
11
What do basophils do?
Modulate hypersensitivity reactions
12
What is the main type of monocyte?
Macrophage
13
What do macrophages do?
Modulate immune reactions, involved in phagocytic clearance, regulatory functions
14
Name the 3 types of lymphocyte.
* B cells
* T cells
* NK cells
15
What are the 3 types of lymphocyte? And what are they involved in?
B cells – humoral immunity (antibodies).
T cells – cell-mediated immunity, regulatory functions.
Natural killer (NK) cells – anti-viral/tumour.
16
What is erythropoiesis?
Production of red cells
17
What is thrombopoiesis?
Production of platelets
18
What is myelopoiesis/granulopoiesis?
Production of bone marrow and all the cells that arise with it
19
What is lymphopoeisis?
Production of lymphocytes
20
In a steady state ....
Cell loss is balanced by cell production
21
What is the lifespan of red cells?
120 days
22
What is the lifespan of neutrophils?
7-8 hours
23
What is the life span of platelets?
7-10 days
24
How many red cells are lost and produced per minute?
~2.5million
25
How many neutrophils are lost and produced per minute?
~1-2million
26
How many platelets are lost and produced per minute?
~1million
27
What do mature cells come from?
Precursor cells
28
What cell is formed just before the reticulocyte? What is the difference between these?
The late normoblast – contains a nucleus which is lost to form the reticulocyte
29
The late normoblast has a nucleus but when it becomes a reticulocyte it loses the nucleus but keeps some RNA
T
30
