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Flashcards in Haemopoiesis Deck (95)
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1

What is haemopoiesis?

Formation of BLOOD cells

2

What is the name for mature red cells?

Erythrocytes

3

Do mature red cells (erythrocytes) have a nucleus?

NO

4

What is the function of erythrocytes?

O2/CO2 transport

5

Do platelets have a nucleus?

NO

6

What is the role of platelets?

They are involved in primary haemostasis

Formation of the platelet plug

7

Name the 3 groups of white cells.

* Granulocytes
* Monocytes - macrophages
* Lymphocytes

8

Name the 3 granulocytes.

* Neutrophils
* Eosinophils
* Basophils

9

What do neutrophils have a role in?

Phagocytosis and acute inflammation

10

What do eosinophils do?

* Destroy parasites.
* Modulate hypersensitivity reactions.

11

What do basophils do?

Modulate hypersensitivity reactions

12

What is the main type of monocyte?

Macrophage

13

What do macrophages do?

Modulate immune reactions, involved in phagocytic clearance, regulatory functions

14

Name the 3 types of lymphocyte.

* B cells
* T cells
* NK cells

15

What are the 3 types of lymphocyte? And what are they involved in?

B cells – humoral immunity (antibodies).
T cells – cell-mediated immunity, regulatory functions.
Natural killer (NK) cells – anti-viral/tumour.

16

What is erythropoiesis?

Production of red cells

17

What is thrombopoiesis?

Production of platelets

18

What is myelopoiesis/granulopoiesis?

Production of bone marrow and all the cells that arise with it

19

What is lymphopoeisis?

Production of lymphocytes

20

In a steady state ....

Cell loss is balanced by cell production

21

What is the lifespan of red cells?

120 days

22

What is the lifespan of neutrophils?

7-8 hours

23

What is the life span of platelets?

7-10 days

24

How many red cells are lost and produced per minute?

~2.5million

25

How many neutrophils are lost and produced per minute?

~1-2million

26

How many platelets are lost and produced per minute?

~1million

27

What do mature cells come from?

Precursor cells

28

What cell is formed just before the reticulocyte? What is the difference between these?

The late normoblast – contains a nucleus which is lost to form the reticulocyte

29

The late normoblast has a nucleus but when it becomes a reticulocyte it loses the nucleus but keeps some RNA

T

30

'Cytoplasmic fragments of megakaryocytes' refers to what cell type?

Platelets