Flashcards in Transfusion Deck (64)
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1
What is the minimum criteria for Hb and weight to be allowed to donate blood?
* Hb 135g/L men
* Hb 125g/L women
* Weight 50 kg
2
Can a donor remain anonymous?
NO - they must always give contact details
3
Blood samples undergo testing for various different viruses including ...
* HIV
* Hep B
* Hep C
* Hep E
* HTLV
* Syphilis
4
What happens during processing of a blood sample?
The bag of blood from the donor is spun to separate all components
5
How are red cells stored?
Red cells stored at 4°C for 35 days
6
How is FFP stored?
FFP stored 30°C for 3 years
7
How are platelets stored?
Platelets stored 22°C for 7 days with agitation
8
Blood components only come from one donor sample
T
9
Blood products can come from many different donors
T
10
Name the 4 different blood components.
* Red cells
* FFP
* Platelets
* Cryoprecipitate
11
Name the 2 different blood products.
* Anti-D immunoglobulin
* Prothrombin complex concentrate
12
Name the 3 different blood products from pharmacy.
* IV immunoglobulin
* Human albumin
* Specific Ig
13
What is an antigen?
Any substance which can trigger an immune response
14
In a RBC, where are antigens present?
On the membrane of a red cell there are many antigens
15
Where is the ABO gene located?
Chromosome 9
16
What do A and B genes code for?
‘A’ and ‘B’ genes code for transferases which modify precursor called ‘H substance’ on red cell membrane
17
What is the relationship between A, B and O?
A and B are co-dominant over O
18
What is the relationship between A and B?
A and B are co-dominant
19
O is ______
Silent
20
We get one gene (A, B or O) from each parent
T
21
What is the most common ABO group?
O
22
What is the least common ABO group?
AB
23
What antigens are present on red cells of group O?
None
24
Phenotype is?
Which antigens are detected
25
Genotype is?
Which genes are present
26
Outline Landsteiner's law.
When an individual lacks the A or B antigen the corresponding antibody is produced in their plasma
Naturally occurring antibodies cause haemolysis of red cells expressing the specific antigen
Makes ABO the most clinically significant blood group system
These start to be formed from 6 months of life, because there is bacteria in the gut with similar appearance to A and B antigen
27
What antibody is present in group A?
Anti B
28
What antibody is present in group B?
Anti A
29
What antibody is present in group AB?
Neither A or B
30
