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Flashcards in Transfusion Deck (64)
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1

What is the minimum criteria for Hb and weight to be allowed to donate blood?

* Hb 135g/L men
* Hb 125g/L women
* Weight 50 kg

2

Can a donor remain anonymous?

NO - they must always give contact details

3

Blood samples undergo testing for various different viruses including ...

* HIV
* Hep B
* Hep C
* Hep E
* HTLV
* Syphilis

4

What happens during processing of a blood sample?

The bag of blood from the donor is spun to separate all components

5

How are red cells stored?

Red cells stored at 4°C for 35 days

6

How is FFP stored?

FFP stored 30°C for 3 years

7

How are platelets stored?

Platelets stored 22°C for 7 days with agitation

8

Blood components only come from one donor sample

T

9

Blood products can come from many different donors

T

10

Name the 4 different blood components.

* Red cells
* FFP
* Platelets
* Cryoprecipitate

11

Name the 2 different blood products.

* Anti-D immunoglobulin
* Prothrombin complex concentrate

12

Name the 3 different blood products from pharmacy.

* IV immunoglobulin
* Human albumin
* Specific Ig

13

What is an antigen?

Any substance which can trigger an immune response

14

In a RBC, where are antigens present?

On the membrane of a red cell there are many antigens

15

Where is the ABO gene located?

Chromosome 9

16

What do A and B genes code for?

‘A’ and ‘B’ genes code for transferases which modify precursor called ‘H substance’ on red cell membrane

17

What is the relationship between A, B and O?

A and B are co-dominant over O

18

What is the relationship between A and B?

A and B are co-dominant

19

O is ______

Silent

20

We get one gene (A, B or O) from each parent

T

21

What is the most common ABO group?

O

22

What is the least common ABO group?

AB

23

What antigens are present on red cells of group O?

None

24

Phenotype is?

Which antigens are detected

25

Genotype is?

Which genes are present

26

Outline Landsteiner's law.

When an individual lacks the A or B antigen the corresponding antibody is produced in their plasma

Naturally occurring antibodies cause haemolysis of red cells expressing the specific antigen

Makes ABO the most clinically significant blood group system

These start to be formed from 6 months of life, because there is bacteria in the gut with similar appearance to A and B antigen

27

What antibody is present in group A?

Anti B

28

What antibody is present in group B?

Anti A

29

What antibody is present in group AB?

Neither A or B

30

What antibody is present in group O?

Anti A and Anti B