Flashcards in Transfusion Deck (64)
What is the minimum criteria for Hb and weight to be allowed to donate blood?
* Hb 135g/L men
* Hb 125g/L women
* Weight 50 kg
Can a donor remain anonymous?
NO - they must always give contact details
Blood samples undergo testing for various different viruses including ...
* Hep B
* Hep C
* Hep E
What happens during processing of a blood sample?
The bag of blood from the donor is spun to separate all components
How are red cells stored?
Red cells stored at 4°C for 35 days
How is FFP stored?
FFP stored 30°C for 3 years
How are platelets stored?
Platelets stored 22°C for 7 days with agitation
Blood components only come from one donor sample
Blood products can come from many different donors
Name the 4 different blood components.
* Red cells
Name the 2 different blood products.
* Anti-D immunoglobulin
* Prothrombin complex concentrate
Name the 3 different blood products from pharmacy.
* IV immunoglobulin
* Human albumin
* Specific Ig
What is an antigen?
Any substance which can trigger an immune response
In a RBC, where are antigens present?
On the membrane of a red cell there are many antigens
Where is the ABO gene located?
What do A and B genes code for?
‘A’ and ‘B’ genes code for transferases which modify precursor called ‘H substance’ on red cell membrane
What is the relationship between A, B and O?
A and B are co-dominant over O
What is the relationship between A and B?
A and B are co-dominant
O is ______
We get one gene (A, B or O) from each parent
What is the most common ABO group?
What is the least common ABO group?
What antigens are present on red cells of group O?
Which antigens are detected
Which genes are present
Outline Landsteiner's law.
When an individual lacks the A or B antigen the corresponding antibody is produced in their plasma
Naturally occurring antibodies cause haemolysis of red cells expressing the specific antigen
Makes ABO the most clinically significant blood group system
These start to be formed from 6 months of life, because there is bacteria in the gut with similar appearance to A and B antigen
What antibody is present in group A?
What antibody is present in group B?
What antibody is present in group AB?
Neither A or B