Head Neck Path Flashcards by Niko McCauley

sequence of development of squamous cell carcinoma

hyperplasia

dysplasia (progressive pleomorphism, hyperchromasia, nuclear size, nucelar/cytomplasmic ratio) (increasing risk with increasing dysplasia)

carcinoma

How well did you know this?

Not at all

Perfectly

tissue type posterial nasal cavity and sinuses

ciliated psuedo stratified columnar

submucosa: sermucinous glands, thickwalled vessels, mixed inflamm cells

septum = cartilage and lamellar bone

How well did you know this?

Not at all

Perfectly

gland with no lymph nodes, drains to oral cavity

submandibular

How well did you know this?

Not at all

Perfectly

candidiasis

white plaque-like psuedo membrane

scraping > erythamatous base

fungal hypahae attached to mucosa

silver stain

How well did you know this?

Not at all

Perfectly

squamous papilloma

soft fingerlike appearance in lingual, labial, buccal, and larynx epithelia, papillary hyperplasia of squamous mucosa with fibrovascular cores

How well did you know this?

Not at all

Perfectly

Salivary glands

epithelial ductal cells

myoepthelial cells

mesenchymal compoeents - mxoid, hyaline, chondroid

pleomorphic adenoma

How well did you know this?

Not at all

Perfectly

most common carcinoma of OC

squamous cell carcinoma

How well did you know this?

Not at all

Perfectly

leukoplakia

white patch caused by epidermal thickening or hyperkeratosis

cannot be scraped off

How well did you know this?

Not at all

Perfectly

localization nasopharyngeal carcinoma

northern african

China and SE Asia

How well did you know this?

Not at all

Perfectly

pathology and associations sjorgream syndrome

associated with other autoimmune

anti-SS-B and SS-A

lymphocyte inflitration of glands with eventual gland destruction

mikulicz disease (benign lymphoepithelial lesion)

How well did you know this?

Not at all

Perfectly

morphology minor salivary glands

unencapsulated

throughout OC

variable - mixed, mucoinous or serous

How well did you know this?

Not at all

Perfectly

common sites of metatasis of oral squamous cell carcinoma

regional lymph nodes (submental, cervical)

lung, liver, bone, mediastinal lymph nodes

How well did you know this?

Not at all

Perfectly

microscopy warthin tumor

bilayered oncocytic (pink) epithelail cells and lymphocyte proliferation

How well did you know this?

Not at all

Perfectly

HPV serotypes associated with sqaumous cell carcinoma

other associations

serotypes 16 and 18

tobacco and alcohol

family history

erythroplakia (common)

leukoplakia

How well did you know this?

Not at all

Perfectly

major and minor salivary glands

perinerual ivasion

cribiform architecture (sieve)

adenoid cystic carcinoma

How well did you know this?

Not at all

Perfectly

sqaumous papilloma association, infection site and gross appearance

HPV

soft fingerlike appearance in lingual, labial, buccal, and larynx epithelia

How well did you know this?

Not at all

Perfectly

gross and microscopic appearnace schneiderian papillmomas

proliferations from schneiderian membrane - nasal mucosa of ciliated columnar cells

How well did you know this?

Not at all

Perfectly

histo Mucoepidermoid carcinoma

parotid and minor salivary glands

squamous, muscous, and intermediate cells

squamous cells with mucin vacuoules

nests of cells with pink cytoplasm,

How well did you know this?

Not at all

Perfectly

most common salivary gland tumor

most common malignant

pleomorphic adenoma

mucoepidermoid carcinoma (maligant)

How well did you know this?

Not at all

Perfectly

parotid and minor salivary glands

squamous, muscous, and intermediate cells

squamous cells with mucin vacuoules

nests of cells with pink cytoplasm,

mucoepidermoid carcinoma

How well did you know this?

Not at all

Perfectly

oral cavitiy candidiasis clinical appearance, microscopy

white plaque-like psuedo membrane

scraping > erythamatous base

fungal hypahae attached to mucosa

silver stain

How well did you know this?

Not at all

Perfectly

gross appearance and microscopy rhinosinusitis

complications?

edamtous nasal mucosa

enlarged turbinates

mixed inflamm infiltrate, edema, thickened basement membrane

complication = polyps

How well did you know this?

Not at all

Perfectly

multinucleated cells with intranuclear viral inclusions, multinucleation, molding, margination herpes somatitis

herpes somatitis

How well did you know this?

Not at all

Perfectly

location, demographics olfactory neuroblastoma (estheisionneruoblastom)

superal and lateral olfactory mucosa of nose

50 years median age

How well did you know this?

Not at all

Perfectly

smaller nests invading below basement membrane deep pink whirling keratin possible invasion to skeletal muscle perineural invasion \> difficult ressection and recurence

squamous cell carcinoma

lorder of likelihood of maligancy in salivary glands

sublingual pervasively malignant minor salivary glands submandibular glands partoid gland tumors more rarely malignant

location, gross and microscopic appearance franchial celft cyst

2nd branchial pouch, anterior border of SCM thin walled, filled with cheesy mucoid material squamous lining, lymphoid tissue resembles metastic squamous carcinoma!

typical disease course nasopharyngeal carcinoma

grow silently until unressectable local and distant metastasis

imunnohistochemistry markers for olfactory neuroblastoma

neurondocrine markers - synaptophysin, chromogranin

histo non-keratinizing nasopharyngeal squamous cell carcinoma

undifferentiated lympoepithelial carcinoma - numerous lymphocytes between tumor cells oscuring epithelial cohesive derivation (sheets of blue lymphocytes wiwth larger carcinoma cells)

symptomology olfactory neruoblastoma

epistais nasal obstruction headache

common location of squamous cell carcinoma

tounge and floor of mouth

association schneiderian papillomas

HPV 6 and 11

presentation sjogren syndrome

(sicca syndrome) dry mouth (xerostomia) dry eyes (keratoconjunctivitis)

3 categories schneiderian papillomas

Exophytic inverted oncocytic

Red granular area with/without elevation, poorly defined boundries

ethroplakia

cellular makeup of major salivary glands

parotid - serous glands (sides) submandibular glands -mainly serous and mucinous (mixed) lublingual gland - mainly mucinous, serous (mucinous midline)

appearance and histo adenoid cystic carcinoma

major and minor salivary glands perinerual ivasion cribiform architecture (sieve)

squamous cell carcinoma histology

same at any site smaller nests invading below basement membrane deep pink whirling keratin possible invasion to skeletal muscle perineural invasion \> difficult ressection and recurence

thyroglassal duct cyst lined with histology

lined with repsiratoyr or squamous epithelium thyroid tissue in wall of cyst

most common infection of OC causes

**candidiasis** dentures Diabetes M steroids/antibiotic therapy widespread cancer imunnosuppression

HPV strains associate with non-keratinizing squamous cell carcinoma

17, P16 IHC (HPV proteins E6 and E7 inactivate p53 and Rb)

undifferentiated lympoepithelial carcinoma - numerous lymphocytes between tumor cells oscuring epithelial cohesive derivation (sheets of blue lymphocytes wiwth larger carcinoma cells)

nasopharyngeal non keratizing squamous cell carcinoma

epithelial dysplasia = proliferation of ___ cells

proliferation of immature basal cells

histology olfactory neuroblastoma

uniform cells with round nuclei and scant cytoplasm salt and pepper chromatin neuroscretory granules rossets or pseudoorsets

Exophytic or inverted or oncocytic

schenederian papilloma

white patch caused by epidermal thickening or hyperkeratosis cannot be scraped off

leukoplakia

typical course olfactory neuroblastoma

locally invasive metastasizes widely 5 year survival 50-70%

pathogenesis/appearance herpes somatitis

intraepithelial edema \> clear fluid vesicle \> rupture \> ulcer

cellular makeup of acinar ductal unit + cell types

serous: basophilicc, zymogen granules mucinous - clear, mucin myoepithelal cells - acini, intercalated ducts

histo nonkeratining squamous cell carcinoma

proliferation of basal cells in sheets (vs nests) brown staining showing inactivation of pathway leading to increased P16 iHC protein

gross appearance vocal cord nodules and polyps

nodules = bilateral on opposing surface of middle third of vocal cord polyps - single in ventricle or reinke's space grossly smooth and round

herpes stomatitis microscopy

multinucleated cells with intranuclear viral inclusions multinucleation, molding, margination (3Ms)

demographics neoplasms of salivary glands

adults, slight female predominance benign 5-7th decade maligancies later

cellular components of peleomorphic adenoma

epithelial ductal cells myoepthelial cells mesenchymal compoeents - mxoid, hyaline, chondroid

2nd branchial pouch, anterior border of SCM thin walled, filled with cheesy mucoid material squamous lining, lymphoid tissue resembles metastic squamous carcinoma!

branchial cleft cyst

most common location of laryngeal carcinoma other locations

glottis (diagnosed early) supraglottic or inflraglottic spread - with hemoptyisis or dysphagia

warthin tumor

restricted to partoid **bilateral** papillary cystic change

erythroplakia

Red granular area with/without elevation, poorly defined boundries

associations nasopharngeal carcinoma

EBV infection salted fish diet smoking heriditary

proliferation of basal cells in sheets (vs nests) brown staining showing inactivation of pathway leading to increased P16 iHC protein

non keratining squamous cell carcinoma

erythroplakia, leukoplakia associated with risk of malignancy?

associated with epithelial displasia (more so erthroplakia) 5-25% risk in leukoplakia 50% risk in erythroplakia

Head Neck Path Flashcards

(62 cards)