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Flashcards in Resp Viruses Deck (52):
1

responsible for summer "cold and flu" resp infections and undifferentiated fevers

enteroviruses

1

___ complications of parainfluenza virus infections common in young,

may progess to ___

lower respiratory conplications

 

Croup

2

basic clinical features influenza

self-limited 3-7 days

secondary bacterial infections cause of death:

strep pneumo

staph a.

haemophilus influenzae

2

subacure scleorising panencephalits in measels infection

CNS - personality

behavior

memory changes

myclonic jerks

spasticity

blindness

3

(drugs)inhibit uncoating by blocking M2 proteins

 amantadine

rimantidine

4

temperature sensitivity rhinovirus

grows better at 33 than 37

4

pharyngocojunctival fever in adenovirus infection 

red eyes

sore throat

febrile

5

vaccine adenovirus

not for public (type 4 and 7 in works)

5

virus morphology picorna

+RNA non-enveloped

7

pathogenesis influenza

infects ciliated epithial cells

replication destroys resp epithelium

cytotoxic T cell - mediated damage

(viremia does NOT play a major role)

7

vaccine respiratory syncytial virus

natural infection does not prevent re-infection

re-infection especially risky in elderly

7

emerging resp viruses isolated to bats > pigs > humans in australia and Asia

hendra virus 

nipah virus

9

dates and transmission H5N1

2003-Junly 2014

does not transmit easily among people

household poultry or contaminated environment

10

adenovirus disease sequale

acute resp disease

pneumonia

pharyngoconjunctival fever

conjunctivitis

GI

hemorrhagic cystitis (bladder inflam)

11

treatment for respiratory syncytial virus 

healthy infant

premature/immunocompromised infant

premature infants

healthy - supportive O2, fluids, nebulized cold steam

premature or immunocomp: aerosolized ribavirin

premature infants: passive immunisation with anti-RSV Ig and humanized monoclonal abx

11

vaccines metapneumovirus

none (or therapies)

12

virus morphology orthomyxo and paramyxo viruses

-RNA,

enveloped

13

influenza A, B C, virus morphology and family

orthomyxoviridae 

segmented -RNA

enveloped

14

atypical measels presentatoin

intense rash

vesicles, petechiae, prupura, or urticaria

15

vaccines Rhinovirus

none

16

antibodies against future influenza infections are specific for

epitopes on hemagglutinin

neuraminidase proteins

17

most common cause of death in children with measles

pneumonia

19

symptomology MERS-CoV

severe pneumonia and renal failure

still birth

nosocomial infections possible

19

post measles encepahlitis

headache

confusion

vomitng

coma after rashi disapates

20

metapneumovirus vs RSV

RSV milder, severe disease only in infants, elderly, immunocompromised

21

parainfluena virus serotypes most likely to cause Croup

Type 1 an d 2

21

infects everyone by age 2

respiratoy syncytial virus

22

metapneumovirus ID'd via

RT-PCR

23

virus morphology corona virus

+RNA

enveloped

25

vaccine Coronavirus SARS

none

26

influenza (drugs) inhibit release of progeny influenza virus  (neuraminidase inhibitors)

Zanamivir

Oseltamivir

27

SARS viral class

coronavirus

28

influenza ___ only undergoes minor antigenic changes (drift)

B

30

rare complications of influenza

myositis and cardiac involvement

guillain Barre 

encephalitis

reye syndrome

31

symptoms EV-D68 enterovirus

severe resp infection

wheezing (higher risk in asthatmatic)

difficulty breathing

(otherwise ill-defined)

32

coronaviruses limited to 

upper RT (invects epithelial cells)

34

infection time for parainfluenza viruses

fall and winter

34

disease states parainfleunza viruses

type 1-4

type 1 Croup

type 2 Croup

type 3 bronchiolitis in small infants

type 4 - mild disease

35

location in RT MERS-CoV

lower resp tract (victims with higher viral loads)

36

clinical consequences of respiratory syncytial viral infection

Children < 1

Children

Adults+older children

bronchitis, pneumoia, fever cough dypsnea and cyanosis

children: febriel rhinitis and pharngitis

adults+older children:  common cold

38

ideal temperature coronaviruses

33-35

39

disease state resp syncytial virus

localized RT infection - no systmemic sprea

airway blockage in infants virused induced CPE includes syncitia (giant cells,) induction of cytonkines

40

respiratory syncytial virus mechanism of airway blockade in infants,

virus induced CPE includes syncitia (multinucleated giant cells)

induction of inflammtory cytokines

41

transmission route SARS coronavirus

source

face-to-face

source: bats, asian animal markets

43

Rhinovirus ___ resistant to uncoating prevention drug mechanisms

rhinovirus C

44

diseases caused by coronaviruses

common colds

45

dates and transmission H7N9

october 2 2014

does not transmit easily among people

47

all children infected by age 5

metapneumovirus

49

vaccine for parainfluenza viruses

none

50

clincical conseuquneces of measels infections

cough 

conjunctivitis

coryza

complications - otitis media, croup, penumonia

(maculopapular rash, photophobia, koplic spots)

51

treatment for severe adenovirus infections in immunocompromised

cidofovir

52

infects humans, bats, camels

does not transfer person-to-person readily

MERS-CoV