Health Psychology midterm 2 Flashcards
Antibodies
Proteins produced in response to stipulations by antigens, which then combine chemically with the antigens to overcome their toxic effects.
Antigens
Foreign substances whose presence stimulates the production of antibodies in the cell tissues.
(Toxin)
Natural/ general /innate immune system (non specific immune system)
- Nonspecific immune system: General set of responses to any kind of infection or disorder, defense against many pathogens
- Macrophages are the cells that engulf pathogens
- Fast acting
- Cytokines
- Natural killer cells
Macrophages
- A phagocyte (certain white blood cells)
- Engulf and digest the foreign invader
- Release interleukin-1
- Release interferon to enhance natural killer cells and inhibit viral reproduction of uninfected cells.
- Directly lill infected cells
- Non specific immunity
Interferon/ natural killer cells
- Lethal chemical that destroys infected cells by injecting lethal chemicals
- An antiviral agent
- Decreases spread of viral infections
- Directly kills cells
- Involved in natural immunity
Specific immune system (acquired immune system)
- Specific immune system: always acquired after birth, fight particular micro organisms and their toxins
- Lymphocytes B (humoral) and T (cell mediated) respond to only one kind of invader
- Delay of up to several days before a full defense can be mounted
- Natural immunity: acquired through breast milk to infant, only temporary. Acquired through disease, if you get measles you develop immunity and you are unlikely to develop it again.
- Artificial immunity: acquired through vaccination and inoculations. Shoots for whooping cough, you won’t get it if you get exposed
- Cytokines
- Slower acting
B lymphocytes
- Provide protection against bacteria, neutralizing toxins produced by bacteria, and preventing viral reinfection
- Confer immunity by production and secretion of antibodies
- Humoral immunity
- Bone marrow
- Specific immunity
T lymphocytes
- When stimulated by appropriate antigens, T cells secrete chemicals that kill invading organisms and infected cells
- Cell-mediated immunity
- From the thymus gland
- Slower acting
- Specific immunity
Autoimmunity
- A condition characterized by a specific humoral or cell-mediated immune response that attacks the body’s own tissues.
- Implicated in arthritis, muscular sclerosis
- Specific immune system
Autoimmune disorders
- The body fails to recognize its own tissue, interprets it as a foreign invader, and produces antibodies to fight it.
- A viral or bacterial infections often precedes the onset of Autoimmune disease
- Stress can aggravate AD
- Genetic make-up may protect or exacerbate AD
- Brought on by unwarranted immune response
Types of infection
Localized
Focal
Systemic
- Localized: infections remain at their original site and do not spread throughout the body.
- Focal: confined to a particular area, but can spread toxins to other parts in the body to cause disruptions
- Systemic: affect a number of areas or body systems
Cytokines
- Released by macrophages,
- nonspecific immunity
- Promote inflammation, fever, and wound healing
Moderators of the stress-immune relationship (351)
- Seeking Social support and perception that one had good emotional support is associated with high NK cells
- Good coping methods like problem solving, stress management, relaxation
- Optimism and coping can influence stress
- Perceived control can limit change in immune parameters
- Meditation
Then relaxation response (physiological characteristics and consequences)
- Initiated by the hypothalamus and parasympathetic nervous system
- Relaxation can increase levels of NK cells and decrease antibody titres (enhance cellular immunity)
- Improves immune function
- Decreases depression
- Lowers cholesterol and blood pressure
The overall effect of stress on the immune system (general and specific)
- Stress suppresses specific immunity and over stimulates non specific immunity
- Chronic stress implicated in chronic inflammation, heart disease, declines in cognitive performance (prevents shut down of natural immune system)
- Cortisol suppresses antibody production, leaving the body vulnerable to disease and infection
- Cortisol is a natural anti inflammatory
- Need cortisol for fight or flight
Immune problems that result from stress
- Astronauts show increase in white blood cells, decrease in NK cells
- Perceived stress associated with lower antibody response to the flu, except those who had strong social support
- Self related emotions can cause changes or elevations to inflammatory cytokines activity
- Living in a disadvantaged neighborhood results in higher levels of inflammatory activity
Cortisol’s effect on the immune system
- Cortisol reduced white blood cells, which reduce ability of these substances to signal and communicate with other aspects of the immune system
- Can trigger aptosis (cell death) of white blood cells
Vaccination
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Measures that psychoneuroimmunologists use (skin puncture)
- Measuring immune products, cytokines, in the blood (may increase in response to stress)
- Examine wound healing or tape stripping ( wounds heal faster when immune system is functioning well), puncture in the forearm, examine how quickly you heal
Teachable moment
The idea that certain times are more effective for teaching particular health practices than others; pregnancy constitutes a teachable moment for getting women to stop smoking
Most effective health communication
- Colorful and vivid communication (case study)
- Expert, like able, prestigious, respected (dr. vs. health fad proponent)
- strong arguments in the beginning and end, not middle of speech
- Message short, clear and direct
- State conclusion explicitly
- Extreme message, but not too extreme
- emphasis on problems that may occur if you don’t stop a bad habit
- Favorable point, benefits to be gained
- Sensitive to cultural norms